Associations of epigenetic aging with self-rated health, access to care, and healthcare utilization in a representative sample of United States adults DOI Creative Commons
Jamaji C. Nwanaji‐Enwerem, Dennis Khodasevich, Nicole Gladish

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 14, 2025

Abstract Background Health status is closely linked to both healthcare access and utilization. While previous research has identified associations between health DNA methylation-based biomarkers of aging (epigenetic aging), studies exploring these relationships in the context utilization remain limited. To address this gap, we analyzed cross-sectional a representative sample 2,343 U.S. adults from 1999–2000 2001–2002 cycles National Nutrition Examination Survey (NHANES). Our study examined self-rated status, access, with seven epigenetic biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNAm Telomere Length (DNAmTL), DunedinPoAm. Results After adjusting for chronological age, demographics, lifestyle factors, insurance, participants good–excellent had 1.58-year lower PhenoAge (95% CI − 2.54, 0.62 P = 0.006) 1.16-year GrimAge2 1.80, 0.53, 0.004) than poor-fair health. Participants who reported having routine place where they received (β 1.44-years, 95% 2.66, 0.22, 0.03) without location. ≥ 10 visits prior year shorter DNAmTL 0.05-kb, 0.09, 0.01, 0.02) < visits. including additional adjustments estimated leukocyte proportions, were hospitalized overnight 0.08, non-hospitalized individuals. Conclusions findings reinforce reports linking better provide new evidence measures If validated, suggest that may be useful studying disease processes assessing outcomes related

Language: Английский

Associations of epigenetic aging with self-rated health, access to care, and healthcare utilization in a representative sample of United States adults DOI Creative Commons
Jamaji C. Nwanaji‐Enwerem, Dennis Khodasevich, Nicole Gladish

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 14, 2025

Abstract Background Health status is closely linked to both healthcare access and utilization. While previous research has identified associations between health DNA methylation-based biomarkers of aging (epigenetic aging), studies exploring these relationships in the context utilization remain limited. To address this gap, we analyzed cross-sectional a representative sample 2,343 U.S. adults from 1999–2000 2001–2002 cycles National Nutrition Examination Survey (NHANES). Our study examined self-rated status, access, with seven epigenetic biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNAm Telomere Length (DNAmTL), DunedinPoAm. Results After adjusting for chronological age, demographics, lifestyle factors, insurance, participants good–excellent had 1.58-year lower PhenoAge (95% CI − 2.54, 0.62 P = 0.006) 1.16-year GrimAge2 1.80, 0.53, 0.004) than poor-fair health. Participants who reported having routine place where they received (β 1.44-years, 95% 2.66, 0.22, 0.03) without location. ≥ 10 visits prior year shorter DNAmTL 0.05-kb, 0.09, 0.01, 0.02) < visits. including additional adjustments estimated leukocyte proportions, were hospitalized overnight 0.08, non-hospitalized individuals. Conclusions findings reinforce reports linking better provide new evidence measures If validated, suggest that may be useful studying disease processes assessing outcomes related

Language: Английский

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