Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation DOI Creative Commons
Péter Bai,

Adrienn Sipos,

Éva Kerekes

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Numerous secreted bacterial metabolites were identified with bioactivity in various neoplasias, including ovarian cancer. One such metabolite is ursodeoxycholic acid (UDCA), a secondary bile acid. Hereby, we assessed the of UDCA cell models cancer, by applying concentrations corresponding to serum reference (300 nM). induced epithelial-to-mesenchymal transition (EMT), increased flux glycolysis and reduced naturally occurring oxidative stress cancer cells. These changes dependent on activation NRF2. The tumoral overexpression UDCA-induced genes humans correlated worse survival. results point out that may have opposite effects different neoplasias raise possibility UDCA-containing remedies long run support progression patients.

Language: Английский

Cancer and the Microbiome of the Human Body DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, María López-Garzón

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790

Published: Aug. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Language: Английский

Citations

4
Circulating microbiome DNA features and its effect on predicting clinicopathological characteristics of patients with colorectal cancer DOI Creative Commons
Liang Ma,

Mingliang Shi,

Xue Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 13, 2025

Colorectal cancer (CRC) presents a complex tumor microenvironment influenced by genetic and microbial factors. Microbial DNA from the gut can translocate into bloodstream, forming circulating microbiome associated with prognosis clinicopathological features. This study investigates peripheral venous blood in CRC patients using 2bRAD-M sequencing evaluates its clinical significance. Peripheral samples 29 (19 males, 10 females; mean age 57 years) healthy controls were analyzed to assess diversity. Additionally, 20 tissue examined via RT-qPCR validate blood-tumor correlations. Statistical analyses evaluated associations between abundance features, including metastasis PD-L1 Combined Positive Score (CPS). Comparative performed identify disease-specific signatures. A total of 270 species identified, dominant phyla Actinomycetota, Bacillota, Bacteroidota, Pseudomonadota. Bosea lupini was significantly stage (p = 0.034), while Mycobacterium tuberculosis 0.022), Porphyromonas pasteri 0.017), 0.045) correlated CPS. Microbes such as lupini, Ralstonia mannitolilytica, suggested potential tumor-derived translocation bloodstream. identifies distinct patients, highlighting specific microbes features disease progression. These findings suggest microbiomes noninvasive biomarkers for therapeutic targets, warranting further investigation larger cohorts.

Language: Английский

Citations

0
Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation DOI Creative Commons

Adrienn Sipos,

Éva Kerekes,

Dóra Szeőcs

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 3, 2025

Language: Английский

Citations

0
Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

Citations

0
Anticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models DOI Creative Commons
Patrik Kovács,

Szandra Schwarcz,

Petra Nyerges

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 11, 2024

Changes to the composition of microbiome in neoplasia, is termed oncobiosis, may affect tumor behavior through changes secretion bacterial metabolites. In this study we show, that ursodeoxycholic acid (UDCA), a metabolite, has cytostatic properties pancreatic adenocarcinoma cell (PDAC) models. UDCA concentrations corresponding human serum reference range suppressed PDAC proliferation. inhibited expression epithelial mesenchymal transition (EMT)-related markers and invasion capacity cells. treatment increased oxidative/nitrosative stress by reducing nuclear factor, erythroid 2-like 2 (NRF2), inducing inducible nitric oxide synthase (iNOS) nitrotyrosine levels enhancing lipid peroxidation. Furthermore, reduced cancer stem proportion Suppression oxidative antioxidants, blunted UDCA-induced reduction stemness. Finally, showed induced mitochondrial metabolism. did not modulate effectiveness chemotherapy agents used adenocarcinoma. The antineoplastic effects UDCA, observed here, contribute induction cytostasis models providing more environment.

Language: Английский

Citations

1
Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation DOI Creative Commons
Péter Bai,

Adrienn Sipos,

Éva Kerekes

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Numerous secreted bacterial metabolites were identified with bioactivity in various neoplasias, including ovarian cancer. One such metabolite is ursodeoxycholic acid (UDCA), a secondary bile acid. Hereby, we assessed the of UDCA cell models cancer, by applying concentrations corresponding to serum reference (300 nM). induced epithelial-to-mesenchymal transition (EMT), increased flux glycolysis and reduced naturally occurring oxidative stress cancer cells. These changes dependent on activation NRF2. The tumoral overexpression UDCA-induced genes humans correlated worse survival. results point out that may have opposite effects different neoplasias raise possibility UDCA-containing remedies long run support progression patients.

Language: Английский

Citations

0