Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection DOI Creative Commons
Zsófia Gáspár, Bálint Gergely Szabó, Andrea Ceglédi

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

The emergence of SARS-CoV-2 has precipitated a global pandemic with substantial long-term health implications, including the condition known as post-acute sequelae infection (PASC), commonly referred to Long COVID. PASC is marked by persistent symptoms such fatigue, neurological issues, and autonomic dysfunction that persist for months beyond acute phase COVID-19. This review examines potential role herpesvirus reactivation, specifically Epstein-Barr virus (EBV) cytomegalovirus (CMV), in pathogenesis PASC. Elevated antibody titers specific T cell responses suggest recent reactivation some patients, although viremia not consistently detected. exhibits endothelial trophism, directly affecting vascular endothelium contributing microvascular pathologies. These pathologies are significant PASC, where may underlie various chronic symptoms. Similarly, herpesviruses like CMV also exhibit which exacerbate damage when reactivated. Evidence suggests EBV could indirectly contribute immune dysregulation, immunosenescence, autoimmune observed Additionally, play genesis through creating mitochondrial dysfunction, though direct confirmation remains elusive. reviewed evidence while their indirect effects, especially context involvement, warrant further investigation.

Language: Английский

The Impact of Chronic Diseases on Cognitive Impairment in Rural Population of India: A Focus on Diabetes, Hypertension, Cardiovascular Disease, and Stroke DOI Creative Commons
J. Ramesh, Anish Mehta, Krishnamurthy Jayanna

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100107 - 100107

Published: Feb. 1, 2025

Language: Английский

Citations

0
Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

Citations

0
Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart–Brain Axis DOI Creative Commons
Teresa Soda, Teresa Pasqua, Giovambattista De Sarro

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2387 - 2387

Published: Oct. 18, 2024

Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in strength. This plasticity often manifests as long-term potentiation (LTP) depression (LTD), which are bidirectional modulations of efficacy. Strong epidemiological experimental evidence show that heart-brain axis could be severely compromised both neurological cardiovascular disorders. Particularly, disorders, such heart failure, hypertension, obesity, diabetes insulin resistance, arrhythmias, may lead cognitive impairment, a condition known cardiogenic dementia. Herein, we review available knowledge on molecular mechanisms dementia arise describe how LTP and/or LTD induction maintenance CA1 region hippocampus metabolic syndrome, arrhythmias. We also discuss emerging endothelial dysfunction contribute directly altering hippocampal impairing synaptically induced activation nitric oxide synthase. A better understanding CV disorders impact proper function synapses will shed novel light underpinnings dementia, thereby providing new perspective for more specific pharmacological treatments.

Language: Английский

Citations

3
Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection DOI Creative Commons
Zsófia Gáspár, Bálint Gergely Szabó, Andrea Ceglédi

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

The emergence of SARS-CoV-2 has precipitated a global pandemic with substantial long-term health implications, including the condition known as post-acute sequelae infection (PASC), commonly referred to Long COVID. PASC is marked by persistent symptoms such fatigue, neurological issues, and autonomic dysfunction that persist for months beyond acute phase COVID-19. This review examines potential role herpesvirus reactivation, specifically Epstein-Barr virus (EBV) cytomegalovirus (CMV), in pathogenesis PASC. Elevated antibody titers specific T cell responses suggest recent reactivation some patients, although viremia not consistently detected. exhibits endothelial trophism, directly affecting vascular endothelium contributing microvascular pathologies. These pathologies are significant PASC, where may underlie various chronic symptoms. Similarly, herpesviruses like CMV also exhibit which exacerbate damage when reactivated. Evidence suggests EBV could indirectly contribute immune dysregulation, immunosenescence, autoimmune observed Additionally, play genesis through creating mitochondrial dysfunction, though direct confirmation remains elusive. reviewed evidence while their indirect effects, especially context involvement, warrant further investigation.

Language: Английский

Citations

1