Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health DOI Creative Commons
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase infection, affecting approximately 10% to over 30% those infected. It presents a significant clinical challenge, notably due pronounced neurocognitive such brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing central role cerebromicrovascular dysfunction. This review investigates key pathophysiological contributing cerebrovascular dysfunction in long and their impacts on health. We discuss how endothelial tropism direct vascular trigger dysfunction, impaired neurovascular coupling, blood–brain barrier disruption, resulting compromised cerebral perfusion. Furthermore, appears induce mitochondrial enhancing oxidative stress inflammation within cells. Autoantibody formation following also potentially exacerbates injury, chronic ongoing compromise. These factors collectively contribute emergence white matter hyperintensities, promote amyloid pathology, may accelerate neurodegenerative processes, including Alzheimer’s disease. emphasizes critical advanced imaging techniques assessing health need for targeted interventions address complications. A deeper understanding essential advance treatments mitigate its long-term consequences.

Language: Английский

Citations

2
Endothelial Colony-Forming Cells (ECFCs) in Cerebrovascular Aging: Focus on the Pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and Treatment Prospects DOI
Sharon Negri,

Zeke Reyff,

Eva Troyano-Rodriguez

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102672 - 102672

Published: Jan. 1, 2025

Language: Английский

Citations

1
Senescence-related genes as prognostic indicators in breast cancer survival DOI Creative Commons
Zoltán Ungvári, Anna Ungvari, Mónika Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Breast cancer is a leading cause of cancer-related mortality among women worldwide, particularly affecting those in their later years. As the incidence breast increases with age, understanding biological mechanisms that link aging and becomes crucial. Cellular senescence, hallmark aging, plays dual role by inhibiting tumorigenesis while also contributing to tumor progression through senescence-associated secretory phenotype (SASP). This study aims investigate prognostic significance senescence-related genes cancer. We utilized SenMayo gene list, comprehensive set genes, analyze expression data from large cohort samples. The was sourced Kaplan–Meier plotter, an integrated database compiles information multiple independent cohorts. Cox proportional hazards regression false discovery rate (FDR) corrections were employed evaluate correlation between survival outcomes, aiming establish signature. Our findings demonstrate higher levels are significantly associated improved survival, lower correlate shorter outcomes. These results suggest pathways play protective cancer, potentially serving as valuable indicators. identification signature based on underscores importance cellular senescence survival. highlights potential biomarkers enhancing patient stratification informing treatment strategies, growing body literature intersection

Language: Английский

Citations

4
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID) DOI Creative Commons

Attila Kállai,

Anna Ungvari,

Dóra Csabán

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

Citations

0