
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 19, 2025
The gut microbiota composition and the expression profiles of microRNAs (miRNAs) in brain tissue, cerebrospinal fluid, blood patients with Alzheimer's disease (AD) differ significantly from those normal cognition function. study aimed to initially explore relationship between plasma exosomal microRNAs, microbiota, cognitive impairment, providing insights into pathogenesis treatment AD. enrolled 8 participants AD cognition. Mini-Mental State Examination (MMSE) was utilized evaluate High-throughput sequencing used identify differentially expressed miRNAs exosomes, while metagenomic employed detect differences abundance microbiota. Furthermore, associations among them were analyzed. Four 14 taxa, which exhibited differential abundance, respectively, comparison group group, identified be associated MMSE scores. Notably, potential probiotics, including Faecalibacterium prausnitzii, Roseburia intestinalis inulinivorans, decreased patients, positive correlations specific miRNAs: correlated miR-3120-3p miR-6529-5p; inulinivorans miR-3120-3p, miR-6529-5p miR-124-3p; prausnitzii miR-3120-3p. revealed a close association miRNAs, impairment AD, suggested that components may serve as biomarkers therapeutic targets for on microbiota-gut-brain axis.
Language: Английский