Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1351 - 1351
Published: April 15, 2025
Vitamin
D
plays
a
crucial
role
in
the
regulation
of
immune
system,
with
immunomodulatory
effects
that
are
key
prevention
colorectal
cancer
(CRC).
Over
past
decades,
research
has
shown
this
steroid
hormone
impacts
much
more
than
bone
health,
significantly
influencing
responses.
enhances
organ
functions
such
as
spleen
and
lymph
nodes,
boosts
T-cell
activity,
which
is
essential
defending
body
against
tumors.
Additionally,
vitamin
mitigates
inflammatory
responses
closely
linked
to
development,
reducing
inflammation
contributes
CRC.
It
acts
via
receptors
(VDRs)
expressed
on
cells,
modulating
Adequate
levels
influence
gene
expression
related
cell
proliferation,
inhibiting
tumor
development.
also
activates
mechanisms
suppress
survival,
migration,
metastasis.
Low
have
been
associated
an
increased
risk
CRC,
deficiency
correlating
higher
disease
incidence.
Lifestyle
factors,
diet
high
red
meat
calories
but
low
fiber,
fruits,
vegetables,
well
physical
inactivity,
contribute
CRC
risk.
Insufficient
calcium
intake
occurrence
poorer
clinical
outcomes.
Maintaining
optimal
adequate
dietary
preventing
improving
patient
prognosis.
This
review
explores
summarizes
findings
from
randomized
trials
assessing
supplementation
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Multiple
myeloma
(MM),
an
incurable
malignancy
of
plasma
cells,
is
predominantly
age-related
disease,
with
the
majority
cases
occurring
in
patients
over
age
60.
Cellular
senescence,
a
fundamental
biological
process
underlying
aging,
has
been
increasingly
recognized
for
its
critical
role
developing
malignancies.
In
this
study,
we
aimed
to
investigate
prognostic
significance
genes
implicated
molecular
mechanisms
senescence
within
large
cohort
MM
patients.
Gene
expression
and
clinical
data
from
1416
were
obtained
four
GEO
datasets
(GSE24080,
GSE4204,
GSE57317,
GSE9782)
integrated
into
unified
database.
The
raw
processed
using
MAS5
normalization,
scaling
adjustments,
JetSet
probe
selection
ensure
cross-platform
comparability.
A
curated
set
senescence-associated
genes,
SenMayo
gene
signature,
was
employed
subsequent
analyses.
final
signature
computed
as
weighted
mean
122
weights
derived
univariate
hazard
ratios.
Prognostic
evaluated
Cox
regression,
Kaplan-Meier
survival
analysis,
multivariate
models
incorporating
parameters
such
gender,
isotype,
subtypes.
False
discovery
rate
(FDR)
correction
applied
statistical
robustness
findings.
strongly
correlated
overall
(HR
=
0.6,
95%
CI
0.47-0.76,
p
1.7e-05).
75th
percent
probability
reached
at
36.1
months
low-expression
patient
group,
compared
57
high-expression
group.
Independent
validation
sufficient
numbers
confirmed
value
(GSE4204:
HR
0.58,
0.39-0.88,
0.0089;
GSE24080:
0.61,
0.45-0.83,
0.0012;
GSE57317:
0.25,
0.08-0.77,
0.0095).
Multivariate
analyses
further
established
independent
factor,
even
when
accounting
sex
isotype.
These
findings
underscore
independence
predictor
multiple
myeloma.
This
provides
clinically
valuable
insights
cellular
disease
progression.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
Delaying
the
initiation
of
cancer
treatment
increases
risk
mortality,
particularly
in
colorectal
(CRC),
which
is
among
most
common
and
deadliest
malignancies.
This
study
aims
to
explore
impact
delays
on
mortality
CRC.
A
systematic
literature
search
was
conducted
PubMed,
Web
Science,
Scopus
for
studies
published
between
2000
2025.
Meta-analyses
were
performed
using
random-effects
models
with
inverse
variance
method
calculate
hazard
ratios
(HRs)
both
overall
cancer-specific
survival
at
4-,
8-,
12-week
delay
intervals,
heterogeneity
assessed
through
I
2
-statistics
publication
bias
evaluated
funnel
plots
Egger’s
test.
total
20
relevant
included
meta-analysis.
The
analyses
all
patients
demonstrated
a
progressively
increasing
12–39%
longer
(4
weeks,
HR
=
1.12;
95%
CI,
1.08–1.16;
8
1.24;
1.16–1.34;
12
1.39;
1.25–1.55).
In
particular,
incrementally
higher
observed
all–cause
4
weeks
(HR
1.14;
1.09–1.18),
1.29;
1.20–1.39),
1.47;
1.31–1.64).
contrast,
analysis
showed
similar
trend
but
did
not
reach
statistical
significance
1.07;
0.98–1.18;
1.15;
0.95–1.39;
1.23;
0.93–1.63).
Treatment
associated
worsening
survival,
each
4-week
increment
leading
substantially
risk.
suggests
that
timely
should
be
prioritized
clinical
practice,
as
these
efforts
can
lead
substantial
improvements
rates.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1351 - 1351
Published: April 15, 2025
Vitamin
D
plays
a
crucial
role
in
the
regulation
of
immune
system,
with
immunomodulatory
effects
that
are
key
prevention
colorectal
cancer
(CRC).
Over
past
decades,
research
has
shown
this
steroid
hormone
impacts
much
more
than
bone
health,
significantly
influencing
responses.
enhances
organ
functions
such
as
spleen
and
lymph
nodes,
boosts
T-cell
activity,
which
is
essential
defending
body
against
tumors.
Additionally,
vitamin
mitigates
inflammatory
responses
closely
linked
to
development,
reducing
inflammation
contributes
CRC.
It
acts
via
receptors
(VDRs)
expressed
on
cells,
modulating
Adequate
levels
influence
gene
expression
related
cell
proliferation,
inhibiting
tumor
development.
also
activates
mechanisms
suppress
survival,
migration,
metastasis.
Low
have
been
associated
an
increased
risk
CRC,
deficiency
correlating
higher
disease
incidence.
Lifestyle
factors,
diet
high
red
meat
calories
but
low
fiber,
fruits,
vegetables,
well
physical
inactivity,
contribute
CRC
risk.
Insufficient
calcium
intake
occurrence
poorer
clinical
outcomes.
Maintaining
optimal
adequate
dietary
preventing
improving
patient
prognosis.
This
review
explores
summarizes
findings
from
randomized
trials
assessing
supplementation
