Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Vascular cognitive impairment (VCI) is a leading cause of age-related decline, driven by cerebrovascular dysfunction and cerebral small vessel disease (CSVD). Emerging evidence suggests that cerebromicrovascular endothelial senescence plays an important role in the pathogenesis VCI promoting blood flow dysregulation, neurovascular uncoupling, blood–brain barrier (BBB) disruption, development microhemorrhages (CMHs). This review explores concept as continuum vascular aging, linking macrovascular atherosclerosis with microvascular dysfunction. It examines mechanisms which drives pathology highlights impact cardiovascular risk factors accelerating these processes. We examine preclinical clinical studies provide compelling atherosclerosis-induced exacerbates impairment. In particular, findings suggest targeting senescent cells through senolytic therapy can restore function improve outcomes experimental models atherosclerosis. Given growing recognition therapeutic target, further research warranted to explore novel interventions such senolytics, anti-inflammatory agents, metabolic modulators. The circulating biomarkers (e.g., senescence-associated secretory phenotype [SASP] components endothelial-derived extracellular vesicles) could enable early detection stratification individuals at high for VCI. Additionally, lifestyle modifications, including Mediterranean diet, hold promise delaying mitigating decline. conclusion, key mechanistic link between Addressing aging modifiable factor targeted offers promising strategy reducing burden preserving populations.

Language: Английский

Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский