Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 709 - 709

Published: Feb. 17, 2025

Type 2 diabetes is a significant health concern in the 21st century, and its prevalence continues to rise despite efforts promote preventive lifestyle changes. This increase has led higher economic burdens, prompting search for non-pharmacological methods manage glucose levels. To assess effects of flaxseed consumption on biochemical markers (glucose, glycated hemoglobin, total cholesterol, triglycerides) adult patients with Oaxaca, Mexico. Participants were recruited randomized into clinical trials between April June 2023, study protocol was approved by Human Research Ethics Committee. Consuming 16 g daily three months decrease glucose, triglyceride levels (p < 0.001) intervention group (n = 82). Belonging control 84) correlated presenting hemoglobin (Spearman's Rho 0.640; p 0.001), 0.352; cholesterol 0.796; triglycerides 0.700; 0.001). A intake an effective supplementary treatment Mexican diabetes, as evidenced reduced group. Potential implications practice: Healthcare providers may consider recommending diets obesity, prediabetes, or improve lipid metabolism overall metabolic health.

Language: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

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A Comparative Assessment of Flaxseed (Linum usitatissimum L.) and Chia Seed (Salvia hispanica L.) in Modulating Fecal Microbiota Composition and Function In Vitro

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

ABSTRACT Flaxseed ( Linum usitatissimum L.) and chia seed Salvia hispanica have become increasingly popular in the design of various functional food products. However, information on their properties is scarce. The aim this study to comparatively evaluate effects dietary fibers (DFs) flaxseed colonic microbiota composition metabolic outputs. neutral acidic monosaccharide compositions DFs were determined using gas chromatography/mass spectrometry (GC/MS) spectrophotometer, respectively. Next, vitro fecal fermentation assays applied, samples collected at different time points for short‐chain fatty acids (SCFA) measurements GC, changes before after evaluated through 16S rRNA sequencing. results revealed that dominated by xylose uronic acid moieties, while was glucose units, indicating are structurally different. Higher SCFA generations observed case flaxseed, suggesting more readily fermentable gut microbiota. differentially impacted OTU level; example, significant increases relative abundances Acidaminococcaceae Bacteroides stercoris related OTUs, which known be propionate producers, but not seed. Interestingly, seed, suppressed growth some pathogenic bacteria. Overall, suggests functionality relation may differ, with being fermented potentially promoting beneficial microbes a greater extent. Thus, could hold promise developing recipes aimed supporting health.

Language: Английский

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