Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4513 - 4519
Published: Oct. 31, 2023
Abstract
An
oxidant‐free
photocatalytic
[2+2+m]
cyclization
of
2‐cyanoaryl
acrylamides
with
2‐bromocarbonyls
is
reported,
enabling
the
assembly
biologically
important
N‐heterocycle‐fused
quinolinones
including
benzo[1,6]naphthyridinones
and
pyrrolo[3,2‐
c
]‐quinolines.
This
protocol
proceeds
through
a
radical
relay
pathway
alkene
difunctionalization
along
an
intramolecular
cyano
insertion
subsequent
site‐specific
functionalization
inert
C(
sp
3
)−H
bond
enabled
by
cyano‐derived
iminyl
radical‐mediated
1,n‐hydrogen
atom
transfer.
Notably,
this
transformation
selectively
formed
two
distinct
C−C
bonds,
one
C−N
bond,
quaternary
carbon
center
in
one‐pot
procedure.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1845 - 1850
Published: Feb. 26, 2024
The
difunctionalization
of
alkenes
using
aryl
thianthrenium
salts
as
the
sources
has
been
reported
sporadically.
However,
four-component
on
basis
not
thus
far
and
still
remains
a
challenge.
Herein,
visible
light/copper
catalysis-enabled
reaction
salts,
DABCO·(SO
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(8), P. 2195 - 2200
Published: Jan. 1, 2024
A
Heck-like
coupling
of
cyclic
sulfonium
salts
with
alkenes
via
selective
C–S
bond
cleavage
using
a
copper
complex
as
photosensitizer
through
visible-light-driven
redox-neutral
process
has
been
developed.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2777 - 2781
Published: Feb. 5, 2024
2,1,3-Benzothiadiazole
is
widely
used
as
a
privileged
scaffold
in
pharmaceuticals
and
organic
functional
materials.
Nonetheless,
many
current
methods
for
the
functionalization
of
2,1,3-benzothiadiazole
rely
on
preactivation,
transition
metal
catalysts/promoters,
or
an
elevated
reaction
temperature.
Herein
we
disclose
transition-metal-free
visible-light-induced
photocatalytic
method
direct
C–H
alkylation
using
readily
accessible
carboxylic
acid
derivatives,
i.e.,
N-hydroxyphthalimide
esters
(NHPEs),
alkylating
reagents
under
room
This
mild
scalable
highlighted
by
late-stage
installation
benzothiadiazole
drugs
natural
products.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(19), P. 3211 - 3226
Published: Aug. 26, 2023
Abstract
Nitrogen
radicals
are
one
of
the
most
useful
reactive
intermediates
for
selective
transposition
via
intramolecular
hydrogen
atom
transfer
(HAT).
The
Hofmann‐Löffler‐Freytag
(HLF)
reaction
is
a
distinctive
radical‐based
approach
in
which
nitrogen
used
remote
C−H
bond
functionalization
HAT.
Due
to
its
excellent
regioselectivity
and
atomic
economy,
HLF
represents
new
preparation
valuable
functional
molecules.
In
this
review,
we
provide
brief
overview
recent
research
advances
mediated
HLF‐type
reactions
involving
intermolecular
cyclization,
δ
‐site
functionalization.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(35), P. 7425 - 7430
Published: Aug. 22, 2024
Presented
herein
is
an
atom-
and
step-economical
method
enabling
the
precise
assembly
of
a
heptacyclic
scaffold
containing
both
azocine
indoline
units
through
cascade
reactions
indolin-1-yl(aryl)methanimines
with
diazo
indanediones.
The
formation
products
involves
C–H
bond
activation
double
carbene
insertion
followed
by
intramolecular
condensation,
retro-[2
+
2]
cycloaddition,
recyclization.
This
reaction
not
only
provided
concise
straightforward
strategy
for
synthesis
otherwise
difficult
to
obtain
compounds
from
readily
available
substrates
but
also
disclosed
unprecedented
mode
derivatives
compounds.
In
general,
this
novel
synthetic
protocol
has
advantages,
such
as
easily
obtainable
substrates,
structurally
sophisticated
products,
procedure,
good
compatibility
diverse
functional
groups,
ready
scalability.
Moreover,
thus
obtained
showed
decent
antiproliferative
activity
against
three
human
cancer
cell
lines.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(3), P. 1387 - 1392
Published: Jan. 1, 2024
A
green
and
sustainable
multicomponent
sulfonylation
starting
from
boronic
acids,
K
2
S
O
5
halides
has
been
developed
using
a
deep
eutectic
solvent
(DES)
as
reaction
medium.
