Supramolecular Assemblies with Aggregation-Induced Emission for in Situ Active Imaging-Guided Photodynamic Therapy of Cancer Cells DOI
Yu Xiang,

Zongze Duan,

Hai Yang

et al.

Published: Jan. 1, 2024

Language: Английский

Macrocycle‐based differential sensing: Design strategies and applications DOI Creative Commons

Jia‐Hong Tian,

Zhe Zheng, Yu‐Chen Pan

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract Differential sensing, inspired by the olfactory systems in mammals, utilizes cross‐reactivity of multiple sensor units toward analytes to generate a distinctive fingerprint for each analyte. Widely acknowledged as robust analytical technique, differential sensing has entered flourishing era with advancement machine learning. Nevertheless, developing and optimizing signal transduction remain significant tasks left chemists. Macrocyclic receptors serve promising materials constructing arrays enhanced cross‐reactivity, facilitated their ease synthesis derivatization, inherent broad‐spectrum encapsulation capability, compatibility responsive approaches. Herein, we present concise overview fundamental processes involved array, encompassing array construction, transduction, data acquisition analysis, an emphasis on unique advantages provided macrocyclic former two aspects. Then, fascinating application scenarios where shine that rely various ingenious strategies. Finally, discuss several issues potential improvement future directions receptor‐based offering forward‐looking perspective.

Language: Английский

Citations

1

Pillarurilarenes: Glycoluril-Expanded Pillararenes DOI

Chao Ruan,

Zhijin Li,

Wenhao Lin

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(19), P. 4122 - 4126

Published: May 2, 2024

Glycoluril-expanded pillararenes composed of glycoluril and dialkoxybenzene units, namely, pillarurilarenes (PURA), were synthesized through a fragment coupling macrocyclization strategy. Partial replacement with endows PURA polarized equatorial methine protons for derivatization or CH–anion binding. Crystal structures pillar[2]uril[4]arene pillar[1]uril[4]arene containing two units one unit, respectively, indicated the inward orientation as also suggested by 1H nuclear magnetic resonance density functional theory calculation. This work lays good foundation expanding using non-aromatic rings.

Language: Английский

Citations

9

Light-Controlled Macrocyclic Supramolecular Assemblies and Luminescent Behaviors DOI Creative Commons

Shuangqi Song,

Hengzhi Zhang,

Yu Liu

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(9), P. 1109 - 1120

Published: Aug. 1, 2024

ConspectusIntelligent supramolecular assemblies can respond well to external stimuli such as pH, temperature, light, electricity, magnetism, and enzymes achieve not only reversible topological morphology changes assembly/disassembly processes but also special physical chemical properties, which are successfully applied biological imaging, cancer treatment, luminescent materials, anticounterfeiting, sensing, molecular switch in chemical, research fields. Among all stimuli-responsive assemblies, light-controlled have always attracted intense attention because light is a kind of clean eco-friendly energy. In this Account, we focus on formed by four types photoresponsive molecules macrocyclic hosts cucurbit[n]urils, cyclodextrins, crown ethers, their regulations materials bioimaging. The cascade between photoisomerization or photoreaction mainly include: 1) based macrocycles diarylethene. As switches, the open-ring closed-ring configurations diarylethenes be reversibly controlled tunable fluorescence resonance energy transfer (FRET) process further regulate behaviors construct intelligent response cell-imaging, multicolor luminescence systems. 2) Light-controlled spiropyran. Different from diarylethenes, spiropyran converse positive charges ring-open merocyanie (MC) state, amphiphilic easy bond with like neutral/negative ring-closed (SP) more likely self-assemble. Therefore, differentiation bonding affinities MC SP light-driven machines. 3) azobenzene, whether azobenzene modified functional guests, through host–guest interactions, behavior regulated apply catalytic activity modulation, induction microtubule (MT) assembly/disassembly, drug delivery, others. 4) anthracene, different anthracene before after photooxidation hosts, dimerization, change morphologies drive phosphorescence dual imaging construction photostimuli-driven lanthanide switch. With creation novel building units modifications molecules, consider that innovation growth should widely used material conversion, real-time cell targeted organic optoelectronic machines, photocatalysis reactions.

Language: Английский

Citations

8

Structure–Activity Relationship Studies Leading to the Discovery of Highly Water-Soluble and Biocompatible Acyclic Cucurbit[n]uril FY-3451 as a Universal Antagonist That Rapidly Reverses Neuromuscular Blocking Agents In Vivo DOI
Ke Feng,

Yue-Yang Liu,

Yang Zong

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

The development of a reversal agent that can rapidly reverse clinically used nondepolarizing neuromuscular blocking agents (NMBAs) has long been challenge. Here, we report the synthesis series highly water-soluble acyclic cucurbit[

Language: Английский

Citations

8

Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene DOI
Xiao-Wen Han, Guo-Ling Zhang, Pu Chen

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

1

Discovery of an Ultralong-acting Nondepolarizing Neuromuscular Blocker That Displays Short Onset Time and On-Demand Rapid Reversal by a Biocompatible Antagonist DOI
Jingyu Yang, Yan Wu,

Yue-Yang Liu

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

The combination of ultralong-acting neuromuscular block and subsequent on-demand rapid reversal may provide prolonged surgeries with improved conditions by omitting continuous or repetitive blocker administration, enabling a more stable predictable hemodynamic profile eliminating residual block. For this target, we prepared 19 imidazolium-incorporated tetracationic macrocycles. In vivo studies rats revealed that one macrocycle (IMC-14) displays extremely high blocking activity. At the dose 12.5-fold ED90, IMC-14 exhibits an onset time shorter than cisatracurium 2-fold duration corresponding to 13 h for human adults. Moreover, within range 12.5–187.5-fold profound induced can be rapidly reversed at any stage highly biocompatible acyclic cucurbit[n]uril antagonist, significantly achieved sugammadex reversing rocuronium, clinically widely used intermediate-acting agent.

Language: Английский

Citations

1

Mechanically robust and dynamic supramolecular polymer networks enabled by [an]daisy chain backbones DOI
Yongming Wang, Yi Ding, Yuhang Liu

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Language: Английский

Citations

3

Sulfonatoproxylated cucurbit[7]urils as highly water-soluble and biocompatible excipients for solubilizing poorly soluble drugs and improving the bioavailability of indomethacin DOI
Peipei Liu, Jie Xing, Yue‐Yang Liu

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110831 - 110831

Published: Jan. 1, 2025

Language: Английский

Citations

0

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy DOI

Xihan Xu,

Juanjuan Li, Jiamin Li

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0

Self-assembly of highly stable uniform single-molecule porphyrin nanomicelles for enhanced photodynamic therapy DOI

Danying Ma,

Jiangshan Zhang,

Yue-Yang Liu

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

0