Published: Jan. 1, 2024
Language: Английский
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
Abstract Differential sensing, inspired by the olfactory systems in mammals, utilizes cross‐reactivity of multiple sensor units toward analytes to generate a distinctive fingerprint for each analyte. Widely acknowledged as robust analytical technique, differential sensing has entered flourishing era with advancement machine learning. Nevertheless, developing and optimizing signal transduction remain significant tasks left chemists. Macrocyclic receptors serve promising materials constructing arrays enhanced cross‐reactivity, facilitated their ease synthesis derivatization, inherent broad‐spectrum encapsulation capability, compatibility responsive approaches. Herein, we present concise overview fundamental processes involved array, encompassing array construction, transduction, data acquisition analysis, an emphasis on unique advantages provided macrocyclic former two aspects. Then, fascinating application scenarios where shine that rely various ingenious strategies. Finally, discuss several issues potential improvement future directions receptor‐based offering forward‐looking perspective.
Language: Английский
Citations
1
Organic Letters, Journal Year: 2024, Volume and Issue: 26(19), P. 4122 - 4126
Published: May 2, 2024
Glycoluril-expanded pillararenes composed of glycoluril and dialkoxybenzene units, namely, pillarurilarenes (PURA), were synthesized through a fragment coupling macrocyclization strategy. Partial replacement with endows PURA polarized equatorial methine protons for derivatization or CH–anion binding. Crystal structures pillar[2]uril[4]arene pillar[1]uril[4]arene containing two units one unit, respectively, indicated the inward orientation as also suggested by 1H nuclear magnetic resonance density functional theory calculation. This work lays good foundation expanding using non-aromatic rings.
Language: Английский
Citations
9
Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(9), P. 1109 - 1120
Published: Aug. 1, 2024
ConspectusIntelligent supramolecular assemblies can respond well to external stimuli such as pH, temperature, light, electricity, magnetism, and enzymes achieve not only reversible topological morphology changes assembly/disassembly processes but also special physical chemical properties, which are successfully applied biological imaging, cancer treatment, luminescent materials, anticounterfeiting, sensing, molecular switch in chemical, research fields. Among all stimuli-responsive assemblies, light-controlled have always attracted intense attention because light is a kind of clean eco-friendly energy. In this Account, we focus on formed by four types photoresponsive molecules macrocyclic hosts cucurbit[n]urils, cyclodextrins, crown ethers, their regulations materials bioimaging. The cascade between photoisomerization or photoreaction mainly include: 1) based macrocycles diarylethene. As switches, the open-ring closed-ring configurations diarylethenes be reversibly controlled tunable fluorescence resonance energy transfer (FRET) process further regulate behaviors construct intelligent response cell-imaging, multicolor luminescence systems. 2) Light-controlled spiropyran. Different from diarylethenes, spiropyran converse positive charges ring-open merocyanie (MC) state, amphiphilic easy bond with like neutral/negative ring-closed (SP) more likely self-assemble. Therefore, differentiation bonding affinities MC SP light-driven machines. 3) azobenzene, whether azobenzene modified functional guests, through host–guest interactions, behavior regulated apply catalytic activity modulation, induction microtubule (MT) assembly/disassembly, drug delivery, others. 4) anthracene, different anthracene before after photooxidation hosts, dimerization, change morphologies drive phosphorescence dual imaging construction photostimuli-driven lanthanide switch. With creation novel building units modifications molecules, consider that innovation growth should widely used material conversion, real-time cell targeted organic optoelectronic machines, photocatalysis reactions.
Language: Английский
Citations
8
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
The development of a reversal agent that can rapidly reverse clinically used nondepolarizing neuromuscular blocking agents (NMBAs) has long been challenge. Here, we report the synthesis series highly water-soluble acyclic cucurbit[
Language: Английский
Citations
8
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
1
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
The combination of ultralong-acting neuromuscular block and subsequent on-demand rapid reversal may provide prolonged surgeries with improved conditions by omitting continuous or repetitive blocker administration, enabling a more stable predictable hemodynamic profile eliminating residual block. For this target, we prepared 19 imidazolium-incorporated tetracationic macrocycles. In vivo studies rats revealed that one macrocycle (IMC-14) displays extremely high blocking activity. At the dose 12.5-fold ED90, IMC-14 exhibits an onset time shorter than cisatracurium 2-fold duration corresponding to 13 h for human adults. Moreover, within range 12.5–187.5-fold profound induced can be rapidly reversed at any stage highly biocompatible acyclic cucurbit[n]uril antagonist, significantly achieved sugammadex reversing rocuronium, clinically widely used intermediate-acting agent.
Language: Английский
Citations
1
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 21, 2024
Language: Английский
Citations
3
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110831 - 110831
Published: Jan. 1, 2025
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
0