Organo-mediator enabled electrochemical transformations

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.

Language: Английский

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Electrochemical umpolung of C‐H nucleophiles bearing three electron‐withdrawing groups to trigger radical 1,2‐alkylarylations of allylic alcohols

Advanced Synthesis & Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract The electrochemical catalyst‐free generation of carbon radicals bearing three electron‐withdrawing groups from the corresponding C−H nucleophiles remains unexplored. To this end, we report a direct electro‐oxidation strategy to access these electrophilic under conditions. Enabled by strategy, radical 1,2‐alkylarylations allylic alcohols was realized, affording β ‐quaternary ketones with high functional group compatibility. This protocol is operationally simple and also easy scale up.

Language: Английский

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Electrochemically Driven Chalcogenative Cyclization of 2-Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

A transition-metal-free electrochemical chalcogenative cyclization of 2-alkynyl aryl oxime with dichalcogenides has been established to assemble valuable 4-organochalcogen isoquinolines concisely. This protocol proceeds via constant electrolysis in a user-friendly undivided cell setup. It circumvents the necessity transition metal catalysts, chemical oxidants, and harsh reaction conditions. The practical utilities current were illustrated by excellent functional group tolerance, remarkable regio-selectivity, easy scalability, mild conditions, transformable isoquinoline products.

Language: Английский

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Electrochemical Benzylic C–H Carboxylation

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Direct benzylic C-H carboxylation stands as a high atom economy, efficient, and convenient route for the synthesis of valuable carboxylic acids, which are great significance in many pharmaceuticals bioactive molecules. However, inherent inertness both bonds carbon dioxide presents challenge further transformations. Herein, we report our efforts to overcome this obstacle via halide-promoted linear paired electrolysis generate various acids. Remarkably, process is transition-metal- base-free, making it environmentally benign cost-effective. Besides, suitable constructing wide range primary, secondary, tertiary acids under mild reaction conditions, demonstrating broad substrate scopes good functional group tolerance. Furthermore, protocol enables direct some drug molecules, including Flurbiprofen, Ibuprofen, Naproxen, facilitates late-stage modification complex compounds, showcasing practical application synthetic chemistry underscores its potential advance related compounds.

Language: Английский

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Electrochemical conversion of CO₂ via C−X bond formation: recent progress and perspective

Chemical Synthesis, Journal Year: 2024, Volume and Issue: 4(4)

Published: Oct. 9, 2024

With the depletion of traditional energy sources and growing environmental concerns, it is becoming increasingly urgent to develop green, low-emission renewable technologies replace fossil fuel-driven methods that emit carbon dioxide (CO2). Currently, electrochemical production high-value-added chemicals fuels from CO2 has aroused great interest scientists. However, make full use for preparation chemicals, necessary expand range electrosynthesis methods, in particular by expanding reaction pathways through with different substrates. In general, can form new covalent bonds substrate molecules formation C−X bonds, including C−H, C−C, C−N, C−O, C−S which would possible products diversifying pathway. this review, we focus on research progress conversion bond formation. We start examining fundamentals reactions summarizing modes. Next, discuss (C−H, C−S) using molecules. Finally, (i) strategies design activity optimization catalyst materials (ii) future development forming five types small are discussed, along an outlook their prospects.

Language: Английский

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Efficient CO2 Electrocarboxylation Using Dye-Sensitized Photovoltaics

Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 40 - 40

Published: Dec. 26, 2024

This paper presents the solar-driven electrocarboxylation of 2-bromopyridine (2-BP) with CO2 into high-value-added chemicals 2-picolinic acid (2-PA) using dye-sensitized photovoltaics under simulated sunlight. Using three series-connected photovoltaic modules and an Ag electrode excellent catalytic performance, a Faraday efficiency (FE) 33.3% is obtained for 2-PA mild conditions. The experimental results show that photovoltaics-driven systems conversion heterocyclic halide to afford value-added carboxylic are feasible effective.

Language: Английский

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Electrochemical demethoxyl-cyanation of methoxyarenes via SNAr

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110810 - 110810

Published: Dec. 1, 2024

Language: Английский

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