Amplified assembly of a chameleon silver nanoclusters-decorated DNA network nanostructure toward nanoconfinement-enhanced ratiometric fluorescence biosensing

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

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Supramolecular charge-reversal pillar[6]arenes-oxaliplatin system for cancer therapy with reduced toxicity and enhanced efficacy

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Smart nucleic acid nanodrug delivery system for precision therapeutics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673

Published: April 3, 2025

Language: Английский

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Layered-Responsive Multivalent Tetrahedral DNA Framework-Decorated CRISPR-Cas12a Nanocapsule Enables Precise and Enhanced Tumor Chemotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

The lack of selective tumor targeting and the high toxicity conventional chemotherapy treatments remain major challenges in cancer therapy. Here, we develop a self-controlled DNA nanostructure-CRISPR-12a system, triple-locked cascade therapy nanocapsule (Tatna), for efficient targeted treatment. Tatna integrates structural tetrahedrons (DTs) with drug-loading capacity, Cas12a/crRNA ribonucleoprotein (Cas12a RNP), doxorubicin (DOX) to enable multisite response precise drug delivery augmented By incorporation nucleolin-targeting aptamer, achieves cell internalization. Encapsulation pH-responsive poly l-lactic-co-glycolic acid (PLGA) ensures stable circulation controlled release both DOX Cas12a until tumor-specific activation acidic microenvironment. RNP, triggered by APE1 mRNA overexpression cells, induces trans-cleavage DTs, releasing transport into nucleus induce enhanced apoptosis. This self-regulating multifunctional approach enhances efficacy while reducing off-target effects. Tatna's programmable, system represents powerful strategy advancing precision medicine personalized

Language: Английский

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Gold Nanocage/DNA Nanoplatforms with Multivalent Aptamers Based on Rolling Circle Amplification for Tumor-Targeted Drug Controlled Release and Synergistic Therapy

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

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Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Due to the inherent immunosuppression and immune evasion of cancer cells, combining photoimmunotherapy with checkpoint blockade leverages phototherapy enhancement, overcoming mutual limitations demonstrating significant anticancer potential. The main challenges include nonspecific accumulation agents, uncontrolled activation, drug carrier safety. Smart DNA nanospheres (NS) is developed targeted delivery controllable release photosensitizers agents achieve effective synergistic therapy minimize side effects. multifunctional NS incorporate a targeting module for programming aptamers, response i‐motif DNA/RNA hybrid sequences, therapeutic packaging PD‐L1 siRNA. navigate tumor site are sequentially activated by intracellular acid enzymes programmed death ligand 1 (PD‐L1) small interfering RNA (siRNA). Besides killing promotion, downregulate expression, alleviating tolerance evasion, thus enhancing response. These results indicate that significantly enhance antitumor responses, synergistically improve efficacy, reduce systemic toxicity. This study broadens application nanomaterials in precision therapy.

Language: Английский

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ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Language: Английский

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