Palladium‐Catalyzed [3+2+1]/[4+2] Heteroannulation of Allylamines with CO and 1,4‐Enynes Leading to 1,7,8,8a‐Tetrahydroisoquinolin‐3(2H)‐ones DOI
Xue Qi, Yang Li,

Fujin Sun

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Comprehensive Summary Aminocarbonylative heteroannulation of unsaturated hydrocarbons with amines and CO has become a key transformation in organic synthesis to build N ‐heterocycles. In this report, new palladium‐catalyzed aminocarbonylative [3+2+1]/[4+2] allylamines 4‐en‐1‐yn‐3‐yl acetates for the 1,7,8,8a‐tetrahydroisoquinolin‐3(2 H )‐ones been developed. The method enables construction two six‐membered rings single reaction step leading formation isoquinolinone scaffolds, featuring excellent selectivity, good functional group compatibility broad substrate scope. A possible mechanism involving Pd‐catalyzed isomerization form allenyl‐Pd intermediate, aminocarbonylation cycloaddition was proposed.

Language: Английский

Palladium‐Catalyzed [3+2+1]/[4+2] Heteroannulation of Allylamines with CO and 1,4‐Enynes Leading to 1,7,8,8a‐Tetrahydroisoquinolin‐3(2H)‐ones DOI
Xue Qi, Yang Li,

Fujin Sun

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Comprehensive Summary Aminocarbonylative heteroannulation of unsaturated hydrocarbons with amines and CO has become a key transformation in organic synthesis to build N ‐heterocycles. In this report, new palladium‐catalyzed aminocarbonylative [3+2+1]/[4+2] allylamines 4‐en‐1‐yn‐3‐yl acetates for the 1,7,8,8a‐tetrahydroisoquinolin‐3(2 H )‐ones been developed. The method enables construction two six‐membered rings single reaction step leading formation isoquinolinone scaffolds, featuring excellent selectivity, good functional group compatibility broad substrate scope. A possible mechanism involving Pd‐catalyzed isomerization form allenyl‐Pd intermediate, aminocarbonylation cycloaddition was proposed.

Language: Английский

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