Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 12, 2025
Comprehensive Summary A dual catalytic manifold that combines photoredox catalysis and phthalate‐catalyzed hydrogen‐atom abstraction process has been developed to realize diverse fragmentation‐functionalization reactions. Key success is photocatalytic generation of tether‐tunable distonic radical anions (TDRAs) as proton‐coupled electron transfer mediators, enabling polarity‐matching‐based formation heteroatom‐centered radicals allows for further controlled exploration chemical space via C–C β ‐scission. These reactions feature exceptionally broad substrate generality, gram‐scale synthesis, potential biocompatibility late‐stage modification complex molecules, while obviating the use stoichiometric often unsafe peroxides in our previous studies. Mechanistic studies support a redox‐neutral relay pathway enabled by situ ‐generated, TDRAs.
Language: Английский