Medicina Clínica, Journal Year: 2023, Volume and Issue: 162(9), P. 448 - 454
Published: Dec. 30, 2023
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Aug. 9, 2024
One major limitation of effective vaccine delivery is its dependency on a robust cold chain infrastructure. While Vesicular stomatitis virus (VSV) has been demonstrated to be an viral vector for diseases including Ebola, -70 °C storage requirement significant accessing disadvantaged locations and populations. Previous work shown thermal stabilization vaccines with combination pullulan trehalose (PT) dried films. To improve the stability VSV, we optimized PT formulation concentrations components, as well drying methodology enhanced vacuum drying. When formulated in films, VSV can stored 32 weeks at 4 less than 2 log PFU loss, 25 2.5 37 3.1 loss. These results demonstrate advancement stabilization, decreasing requirements vectored vaccines.
Language: Английский
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Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1090 - 1090
Published: Sept. 24, 2024
Background/Objectives. Many vaccines have been developed in recent decades, and many more will be available the future. When new safe effective are available, decision-makers must extensively assess them before including national immunization plan issuing recommendations. The Health Technology Assessment (HTA) could an objective, transparent, comprehensive approach to guiding decision-making process for use of vaccines. Objectives Methods. aim this study was review indications HTA contained Italian institutional documents on vaccination, namely National Immunization Plans (NIPs) full reports vaccines, assessing their availability at time recommendations’ introductions. Results. has recognised as eligible deciding upon introduction through NIPs 2012–2014 2017–2019, last NIP, 2023–2025, highlights lack funding dedicated production independent that can used In 2007–2023, twenty were published Italy: eight influenza five Human Papilloma Virus (HPV), three each meningococcal pneumococcal one rotavirus vaccine. applied with different purposes, evaluation or re-assessment, but it not always timely respect both marketing authorisation recommendations use. Conclusions. As considered best tool disentangle overall value would desirable provide evidence efficient resource This calls action improve transfer results decision-makers, try fill gap between research decision foster evidence-based
Language: Английский
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Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(4), P. 729 - 742
Published: Feb. 23, 2023
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 661 - 661
Published: Feb. 16, 2023
In omics sciences, many compounds are measured simultaneously in a sample single run. Such analytical performance opens up prospects for improving cellular cancer vaccines and other cell-based immunotherapeutics. This article provides an overview of proteomics technology, known as cell proteomic footprinting. The molecular phenotype cells is highly variable, their antigenic profile affected by factors, including isolation from the tissue, cultivation conditions, storage procedures. makes therapeutic properties cells, those used vaccines, unpredictable. Cell footprinting it possible to obtain controlled products. Namely, this technology facilitates authentication quality control regarding phenotype, which directly connected with Protocols crucial moments, footprint processing, recommendations implementation described paper. provided footprints paper program source code processing contribute fast development manufacturing
Language: Английский
Citations
1
Medicina Clínica, Journal Year: 2023, Volume and Issue: 162(9), P. 448 - 454
Published: Dec. 30, 2023
Citations
1