Antiviral Research, Journal Year: 2024, Volume and Issue: unknown, P. 106042 - 106042
Published: Nov. 1, 2024
Language: Английский
Biosafety and Health, Journal Year: 2024, Volume and Issue: 6(5), P. 310 - 318
Published: July 14, 2024
Biosafety hazards can trigger a host immune response after infection, invasion, or contact with the host. Whether infection microorganism results in disease biosafety concerns depends to large extent on status of population. Therefore, it is essential investigate immunological characteristics and mechanisms biological threats agents protect more effectively. Emerging re-emerging infectious diseases, such as current coronavirus 2019 (COVID-19) pandemic, have raised regarding both immunology worldwide. Interdisciplinary studies involved are relevant many fields, including development vaccines other interventions monoclonal antibodies T-cells, herd immunity (or population-level barrier immunity), immunopathology, multispecies immunity, i.e., animals even plants. Meanwhile, advances science technology occurring rapidly, resulting important research achievements that may contribute recognition emerging hazards, well early warning, prevention, defense systems. This review provides an overview interdisciplinary field immunology. Close collaboration innovative application becoming for human health.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1331 - 1331
Published: Oct. 19, 2024
Enteroviruses have been a historical concern since the identification of polioviruses in humans. Wild almost eliminated, while multiple species non-polio enteroviruses and their variants co-circulate annually. To date, at least 116 types found humans are grouped into Enterovirus A-D Rhinovirus A-C. However, there few available antiviral drugs, especially with universal pharmaceutical effect. Here, we demonstrate that peptide P25 from EV-D68 has broad activity against EV vitro. P25, derived HI loop β-I sheet VP1, operates through conserved hydrophilic motif -R---K-K--K- hydrophobic F near N-terminus. It could prevent viral infection EV-A71 by competing for heparan sulfate (HS) receptor, binding stabilizing virions suppressing release genome. also inhibited generation infectious particles reducing protein synthesis. The molecular docking revealed might bind to pocket opening area, potential target broad-spectrum antivirals. Our findings implicate effects including blocking HS impeding genome release, progeny particles, which be novel anti-enterovirus drug candidate.
Language: Английский
Citations
1
hLife, Journal Year: 2023, Volume and Issue: 2(1), P. 43 - 46
Published: Oct. 12, 2023
Language: Английский
Citations
2
Current Research in Microbial Sciences, Journal Year: 2023, Volume and Issue: 6, P. 100208 - 100208
Published: Dec. 3, 2023
The unceasing global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) calls for the development novel therapeutics. Although many newly developed antivirals and repurposed have been applied to treatment disease 2019 (COVID-19), showing satisfactory clinical efficacy are few in number. In addition, loss sensitivity variants concern (VOCs) lack oral bioavailability also limited application some antivirals. These facts remind us develop more potent broad-spectrum with better pharmacokinetic/pharmacodynamic properties fight against infections from SARS-CoV-2, its variants, other human coronaviruses (HCoVs). this review, we summarize latest advancements by SARS-CoV-2 variants.
Language: Английский
Citations
2
Antiviral Research, Journal Year: 2024, Volume and Issue: unknown, P. 106042 - 106042
Published: Nov. 1, 2024
Language: Английский
Citations
0