Gut microbes-muscle axis in muscle function and meat quality

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

---

A novel zearalenone lactonase can effectively mitigate zearalenone-induced reproductive toxicity in gilts

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108257 - 108257

Published: Jan. 1, 2025

Language: Английский

---

The association between Dietary Index for Gut Microbiota and sarcopenia: the mediating role of Dietary Inflammatory Index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Background Given the global changes in environmental and dietary habits, understanding potential impact of factors diet-related inflammation on skeletal muscle diseases, including sarcopenia, is crucial. Investigating these relationships can aid development more effective prevention strategies. This study used Dietary Index for Gut Microbiota (DI-GM) Inflammatory (DII) as variables. DI-GM a scoring system to assess influence diet health. Additionally, DII quantifies inflammatory diet. explores association between sarcopenia evaluates whether moderates this relationship. Methods conducted cross-sectional analysis 9,470 participants from 2011–2018 NHANES database. Multivariable logistic regression, restricted cubic splines (RCS), subgroup were employed examine prevalence sarcopenia. mediation was performed investigate associations DII, DI-GM, Results A total included study, whom 823 (7%) had After adjusting all variables using multivariable each one-unit increase associated with 15% decrease (OR = 0.85, 95% CI: 0.77, 0.94), while 28% 1.28, 1.17, 1.41). Furthermore, results remained robust when divided into tertiles. RCS revealed significant linear relationship The also showed that above robust. Mediation 55% mediated by ( P < 0.001). Conclusion Adhering recommendations based may reduce appears mediate relationship, suggesting an anti-inflammatory could offer benefits.

Language: Английский

---

Transcriptome Analysis of miRNA and mRNA in Porcine Skeletal Muscle following Glaesserella parasuis Challenge

Genes, Journal Year: 2024, Volume and Issue: 15(3), P. 359 - 359

Published: March 13, 2024

Glaesserella parasuis (G. parasuis) causes systemic infection in pigs, but its effects on skeletal muscle and underlying mechanisms are poorly understood. We investigated G. colostrum-deprived piglets, observing decreased daily weight gain upregulation of inflammatory factors muscle. Muscle fiber area diameter were significantly reduced the treated group (n = 3) compared to control 3), accompanied by increased expression FOXO1, FBXO32, TRIM63, CTSL, BNIP3. Based mRNA microRNA (miRNA) sequencing, we identified 1642 differentially expressed (DE) mRNAs 19 known DE miRNAs tissues between two groups. predicted target genes with opposite patterns found significant enrichment activation FoxO signaling pathway. that upregulated core effectors FOXO1 FOXO4 targeted downregulated ssc-miR-486, ssc-miR-370, ssc-miR-615, ssc-miR-224. Further investigation showed their downstream involved protein degradation also ssc-miR-194a-5p, ssc-miR-194b-5p. These findings suggest atrophy piglets through accelerated mediated “miRNAs-FOXO1/4” axis, while further research is necessary validate regulatory relationships. Our results provide new insights into understanding inflammation growth caused role bacterial pathogenesis.

Language: Английский

---

The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

---