The Interplay of Selenium and Human Health

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

This chapter delves into the intriguing dual nature of selenium (Se), a vital yet paradoxical essential trace element for human health. While indispensable numerous physiological processes, Se has an extremely narrow margin between its benefits and potential toxicity, making intake delicate balancing act. Still, consumption varies globally due to dietary habits, geographic differences, environmental conditions. Se’s history, sources, biomarkers, nutritional guidelines, deficiency toxicity implications are discussed. It also provides in-depth look at pivotal role selenoproteins, including their synthesis, various types, functions, concerns arising from or genetic variations. From supporting brain, fertility, development, immunity regulating thyroid function, these proteins illustrate multifaceted importance in biology. Notably, emerged as contaminant that warrants attention. To address this challenge, contamination remediation strategies, analysis methods were summarized.

Language: Английский

Selenium Promotes Neural Development Through the Regulation of GPX4 and SEPP1 in an iPSC-derived Neuronal Model

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123011 - 123011

Published: Dec. 15, 2024

Language: Английский