The Tumor Microenvironment Remodeled by Epstein–Barr Virus: From Primary Site to Distant Metastatic Niche DOI Open Access
Qiuyun Li,

Yuping Liu,

Yong Chen

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2025, Volume and Issue: 48(5), P. 495 - 506

Published: May 1, 2025

Epstein-Barr virus (EBV) is one of the most pervasive viruses worldwide, and EBV infection inextricably linked to a multitude lymphoid epithelial neoplasms. responsible for advancement malignant disease by modifying tumor microenvironment (TME), which sophisticated evolving system that facilitates growth, invasion, metastasis. has profound impact on cellular noncellular components constitute TME. Our review presents summary composition EBV-remodeled TME, with particular focus EBV-induced functional phenotypes in non-tumor cells. Furthermore, we discuss potential reversing EBV-driven TME remodeling as therapeutic strategy treating malignancies associated infection.

Language: Английский

Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization DOI Creative Commons
Cong Sun,

Xin‐Yan Fang,

Guo‐Long Bu

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115168 - 115168

Published: Jan. 1, 2025

Highlights•Cryo-EM structure of EBV gp350-CR2 complex at a resolution 3.29 Å•Depiction polar and glycan-free contacting interface•Key residue divergence in CR2 affects host tropism•Designed CR2-Fc neutralizes B cell infection by targeting 72A1 epitopeSummaryEpstein-Barr virus (EBV) is an oncogenic associated with multiple lymphoid malignancies autoimmune diseases. During cells, uses its major glycoprotein gp350 to recognize the receptor CR2, initiating viral attachment, process that has lacked direct structural evidence for decades. In this study, we resolved complex, elucidated their key interactions, determined site-specific N-glycosylation map gp350. Our findings reveal primarily binds through electrostatically complementary interface diversity residues across different species influences selectivity mediated With confirmed binding, constructed antibody analog targets vulnerable site gp350, demonstrating potent neutralization effect against cells. work provides essential insights into mechanism tropism, suggesting potential antiviral agent.Graphical abstract

Language: Английский

Citations

2
Understanding EBV Infection and EBV-Associated Lymphomas in children DOI
Paola Chabay

Virology, Journal Year: 2025, Volume and Issue: 608, P. 110544 - 110544

Published: April 17, 2025

Language: Английский

Citations

0
The Tumor Microenvironment Remodeled by Epstein–Barr Virus: From Primary Site to Distant Metastatic Niche DOI Open Access
Qiuyun Li,

Yuping Liu,

Yong Chen

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2025, Volume and Issue: 48(5), P. 495 - 506

Published: May 1, 2025

Epstein-Barr virus (EBV) is one of the most pervasive viruses worldwide, and EBV infection inextricably linked to a multitude lymphoid epithelial neoplasms. responsible for advancement malignant disease by modifying tumor microenvironment (TME), which sophisticated evolving system that facilitates growth, invasion, metastasis. has profound impact on cellular noncellular components constitute TME. Our review presents summary composition EBV-remodeled TME, with particular focus EBV-induced functional phenotypes in non-tumor cells. Furthermore, we discuss potential reversing EBV-driven TME remodeling as therapeutic strategy treating malignancies associated infection.

Language: Английский

Citations

0