The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106836 - 106836

Published: Feb. 1, 2025

Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality disability rates. At present, the incidence of IS increasing annually, with notable trend towards younger affected individuals. Recent discoveries concerning "gut-brain axis" have established connection between gut brain. Numerous studies revealed intestinal microbes play crucial role in onset, progression, outcomes IS. They are involved entire pathophysiological process through mechanisms such as chronic inflammation, neural regulation, metabolic processes. Although numerous explored relationship microbiota, comprehensive analyses specific microbiota relatively scarce. Therefore, this paper provides an overview typical changes following investigates microorganisms context. Additionally, it presents analysis post-stroke microbiological therapy diet. The aim to identify potential microbial targets for therapeutic intervention, well highlight benefits therapies significance dietary management. Overall, seeks provide key strategies treatment management IS, advocating healthy diets health programs Meanwhile, may offer new perspective on future interdisciplinary development neurology, microbiology nutrition.

Language: Английский

Indole lactic acid derived from Akkermansia muciniphila activates the aryl hydrocarbon receptor to inhibit ferroptosis in ischemic stroke

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский