Mathematical modelling of reoviruses in cancer cell cultures

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0318078 - e0318078

Published: April 28, 2025

Oncolytic virotherapy has emerged as a potential cancer therapy, utilizing viruses to selectively target and replicate within cells while preserving normal cells. In this paper, we investigate the oncolytic of unmodified reovirus T3wt relative mutated variant SV5. animal cell monolayer experiments it was found that SV5 more T3wt. forms larger sized plaques on monolayers spreads farther distances from initial site infection compared Paradoxically, attaches less efficiently than T3wt, which lead us hypothesize there might be an optimal binding affinity with maximal activity. To understand relationship between process virus spread for SV5, employ mathematical modelling. A reaction-diffusion model is applied, fit available data then validated were not used fit. Analysis our shows rate leads maximum viral monolayer, estimate value Moreover, find burst size important parameter spread, combination efficient large sizes promising direction further develop anti-cancer viruses.

Language: Английский

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Oscillations in a Spatial Oncolytic Virus Model

Bulletin of Mathematical Biology, Journal Year: 2024, Volume and Issue: 86(8)

Published: June 19, 2024

Language: Английский

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Oscillations in a Spatial Oncolytic Virus Model

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 20, 2023

Abstract Virotherapy treatment is a new and promising target therapy that selectively attacks cancer cells without harming normal cells. Mathematical models of oncolytic viruses have shown predator-prey like oscillatory patterns as result an underlying Hopf bifurcation. In spatial context, these oscillations can lead to different spatio-temporal phenomena such hollow-ring patterns, dispersed patterns. this paper we continue the systematic analysis discuss their relevance in clinical context. We consider bifurcation spatially explicit reaction-diffusion model find above mentioned virus infection The desired pattern for tumor eradication hollow ring exact conditions its occurrence. Moreover, derive minimal speed travelling invasion waves virus. Our numerical simulations 2-D reveal complex interactions phenomenon periodic peak splitting. An effect cannot explain with our current methods.

Language: Английский

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On the equivalence between Agent-Based and Continuum models for cell population modeling. Application to glioblastoma evolution in microfluidic devices

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 7, 2024

A bstract Mathematical models are invaluable tools for understanding the mechanisms and interactions that control behavior of complex systems. Modeling a problem as cancer evolution includes many coupled phenomena being therefore impossible to obtain sufficient experimental results fully evaluate all possible conditions. In this work, we focus on Agent-Based Models (ABMs), these allow more complete interpretable information at individual level than other types in silico models. However, ABMs, need parameters, requiring cellular environmental levels be calibrated. To overcome propose complementary approach traditional calibration methods. We used existent continuum able reproduce data, validated with fitted establish relationships between parameters both, agent-based models, simplify improve process adjusting ABM. With approach, it is bridge gap both kinds allowing work them simultaneously take advantage benefits each them. illustrate methodology, glioblastoma (GB) modeled an example application. The resulting ABM obtains very similar those previously obtained model, replicating main histopathological features (the formation necrotic cores pseudopalisades) appearing several different vitro experiments microfluidic devices, ABMs have additional advantages: since they also incorporates inherent random effects present Biology, providing natural explanation deeper biological processes. Moreover, relevant can easily incorporated, such mechanical interaction cells or environment, angiogenic processes cell concentrations far from requirement happens, intance, immune cells.

Language: Английский

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Mathematical insights into cancer-immune dynamics modulated by immunotherapy and interleukins

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

In this work, we develop a new mathematical model to describe the tumor-immune system interactions in presence of interleukins and recently developed immunotherapy. We at cellular level, using approach Kinetic Theory active particles, by considering four populations, namely tumor cells, activated immune cells interleukins.We also derive macroscopic relative tothe kinetic study well-posedness Cauchy problem for thecorresponding equations.Then, determine equilibrium states investigate their asymptotic stability. Particular attention is devoted global stability biologically meaningful tumor-free equilibrium.Some numerical simulations are performed view illustrating behaviour solutionpredicted theoretical analysis. AMS Subject Classification: 82C40, 92B05, 92-10, 37N25.

Language: Английский

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