Vascular risk factors and astrocytic marker for the glymphatic system activity DOI Creative Commons
Yi‐Chia Wei, Chih‐Chin Heather Hsu,

Wen‐Yi Huang

et al.

La radiologia medica, Journal Year: 2023, Volume and Issue: 128(9), P. 1148 - 1161

Published: July 18, 2023

Abstract Objectives Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the space (DTI-ALPS) is an established method measuring glymphatic activity, but comprehensive investigations into its influential factors are lacking. Methods Community-dwelling older adults underwent MRI scans, neuropsychiatric, and multi-domain assessments. Blood biomarker tests included glial fibrillary acidic protein (GFAP) for astrocyte injury. Results In 71 enrolled participants, DTI-ALPS index was associated with modifiable factors, including lipid profile (high-density lipoprotein, r = 0.396; very-low-density − 0.342), glucose intolerance (diabetes mellitus, standardized mean difference (SMD) 0.7662; glycated hemoglobin, 0.324), obesity (body mass index, 0.295; waist, 0.455), metabolic syndrome (SMD 0.6068), cigarette-smoking 0.6292), renal clearance (creatinine, 0.387; blood urea nitrogen, 0.303). Unmodifiable associative were age ( 0.434) sex 1.0769) (all p < 0.05). A correlation GFAP noticed 0.201, one-tailed t-test assumption that injury impaired 0.046). Their cognitive correlations diverged, domain-specific (Facial Memory Test, 0.272, 0.022) global cognition-related (MoCA, 0.264, 0.026; ADAS-cog, 0.304, 0.010). Conclusion This revealed multiple unmodifiable association to image marker. correlated various known increase risk vascular diseases such as atherosclerosis. Furthermore, indices, this connection might be a link water regulation between two systems. addition, biomarker, plasma GFAP, potential marker system; however, more research needed confirm effectiveness.

Language: Английский

Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Japanese Journal of Radiology, Journal Year: 2021, Volume and Issue: 40(2), P. 147 - 158

Published: Aug. 14, 2021

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate brain's glymphatic function or interstitial fluid dynamics. This study aimed reproducibility of DTI-ALPS and effect modifications in imaging data evaluation.Seven healthy volunteers were enrolled this study. Image acquisition performed for test-retest using a fixed sequence modified methods which included placement region interest (ROI), plane, head position, averaging, number motion-proving gradients, echo time (TE), different scanner. ALPS-index values evaluated change conditions listed above.This by showed very high (intraclass coefficient = 0.828) value. bilateral ROI higher reproducibility. averaging difference scanner did not influence values. However, modification plane position impaired reproducibility, gradients affected from 12-axis DTI 3-axis diffusion-weighted (DWI) good correlation (r 0.86). Also, shorter TE resulted larger value ALPS-index.ALPS index robust under even when scanners used. ALPS influenced gradient axes, sequence. These factors should be uniformed planning studies. possibility develop DWI-ALPS three axes also suggested.

Language: Английский

Citations

170
Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson’s disease DOI Creative Commons
Ting Shen,

Yumei Yue,

Fang Ba

et al.

npj Parkinson s Disease, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 21, 2022

The brain glymphatic system is involved in the clearance of misfolding α-synuclein, impaired may contribute to progression Parkinson's disease (PD). We aimed analyze diffusion tensor image along perivascular space (DTI-ALPS) and (PVS) burden reveal relationship between PD. A cross-sectional study using a 7 T MRI 76 PD patients 48 controls was performed evaluate brain's system. DTI-ALPS PVS basal ganglia were calculated. Correlation analyses conducted DTI-ALPS, clinical features. detected lower subgroup relative controls, differences more pronounced with Hoehn & Yahr stage greater than two. decreased only evident left hemisphere early but both hemispheres advanced patients. Decreased also correlated longer duration, higher Unified Disease Rating Scale motor score (UPDRS III) UPDRS total scores, as well levodopa equivalent daily dose. Moreover, increased burden, indexes severity. This demonstrated PD, which might initiate from progressively involve right progression. index indicating that metrics could provide supporting evidence an evaluation are potential imaging biomarkers for

Language: Английский

Citations

88
Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

Citations

64
Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson’s disease DOI
Yan Qin, Runcheng He, Juan Chen

et al.

Journal of Neurology, Journal Year: 2023, Volume and Issue: 270(5), P. 2649 - 2658

Published: March 1, 2023

Language: Английский

Citations

45
The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging DOI Creative Commons
Shinji Naganawa, Toshiaki Taoka, Rintaro Ito

et al.

Investigative Radiology, Journal Year: 2023, Volume and Issue: 59(1), P. 1 - 12

Published: March 10, 2023

Abstract The concept of the glymphatic system was proposed more than a decade ago as mechanism for interstitial fluid flow and waste removal in central nervous system. function has been shown to be particularly activated during sleep. Dysfunction implicated several neurodegenerative diseases. Noninvasive vivo imaging is expected useful elucidating pathophysiology these Currently, magnetic resonance most commonly used technique evaluate humans, large number studies have reported. This review provides comprehensive overview investigations human using imaging. can divided into 3 categories, including without gadolinium-based contrast agents (GBCAs), with intrathecal administration GBCAs, intravenous GBCAs. purpose examine not only movement brain parenchyma, but also dynamics perivascular subarachnoid spaces, well parasagittal dura meningeal lymphatics. Recent research even extended include eye inner ear. serves an important update guide future directions.

Language: Английский

Citations

42
Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease DOI Creative Commons
Colin D. McKnight, Paula Trujillo, Alexander M. Lopez

et al.

Parkinsonism & Related Disorders, Journal Year: 2021, Volume and Issue: 89, P. 98 - 104

Published: June 10, 2021

Language: Английский

Citations

102
Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease DOI Creative Commons
Xinxin Ma, Shuhua Li,

Chunmei Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Nov. 15, 2021

Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using diffusion tensor image analysis along perivascular space (DTI-ALPS) methods. Methods: In total, 71 idiopathic PD and 36 age- sex-matched normal controls (NCs) were involved. Patients divided into early ( n = 35) late 36) subgroups, based on Hoehn Yahr (HY) stages. We calculated diffusivity spaces (ALPS), as well projection fibers association separately, acquire ALPS index. Enlarged (EPVS) periventricular white matter hyperintensities also rated. Differences index between group NCs two subgroups compared. addition, a multivariate logistic regression conducted investigate clinical variables. Results: revealed lower than p 0.010). exhibited significantly 0.006). However, there no marked differences noticed subgroups. group, positive correlation Mini-Mental State Examination (MMSE) score (β 0.021, 0.029) negative EPVS −0.050, 0.034), after controlling for multiple inversely associated age −0.012, 0.004). Conclusion: Impairment is involved PD. DTI-ALPS could be promising biomarker

Language: Английский

Citations

90
The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging DOI Creative Commons
Shinji Naganawa, Toshiaki Taoka

Magnetic Resonance in Medical Sciences, Journal Year: 2020, Volume and Issue: 21(1), P. 182 - 194

Published: Nov. 26, 2020

The central nervous system (CNS) was previously thought to be the only organ lacking lymphatic vessels remove waste products from interstitial space. Recently, based on results animal experiments, glymphatic hypothesized. In this hypothesis, cerebrospinal fluid (CSF) enters periarterial spaces, space of brain parenchyma via aquaporin-4 (AQP4) channels in astrocyte end feet, and then exits through perivenous space, thereby clearing products. From drains into subarachnoid meningeal lymphatics parasagittal dura. It has been reported that is particularly active during sleep. Impairment function might a cause various neurodegenerative diseases such as Alzheimer's disease, normal pressure hydrocephalus, glaucoma, others. Meningeal regulate immunity CNS. Many researchers have attempted visualize structure vivo using MR imaging. review, we aim summarize these imaging studies discuss significance, current limitations, future directions. We also significance cyst formation along superior sagittal sinus, which recently discovered downstream system.

Language: Английский

Citations

77
Glymphatic dysfunction in isolated REM sleep behavior disorder DOI Open Access
Dong Ah Lee, Ho‐Joon Lee, Kang Min Park

et al.

Acta Neurologica Scandinavica, Journal Year: 2021, Volume and Issue: 145(4), P. 464 - 470

Published: Dec. 16, 2021

This study aimed to evaluate glymphatic-system function in patients with isolated rapid eye movement sleep behavior disorder (iRBD) comparison healthy controls by using diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) method. We hypothesized that iRBD may show dysfunction.We retrospectively enrolled 18 and age- sex-matched controls. All participants underwent DTI magnetic resonance (MRI) same 3T MRI scanner, DTI-ALPS index was calculated data. evaluated differences between In addition, we correlation demographic polysomnographic characteristics.The significantly different groups; it lower than (1.5647 vs. 1.7612, p = .0157). The did not correlate characteristics, including age, Epworth Sleepiness Scale score, total time, efficiency, stage N1 ratio, N2 N3 R apnea-hypopnea index.The controls, indicating presence of dysfunction iRBD. Our also suggests could serve as a biomarker for evaluating neurological disorders.

Language: Английский

Citations

60
Impaired Glymphatic System Actions in Obstructive Sleep Apnea Adults DOI Creative Commons
Bhaswati Roy, Alba Núñez,

Ravi Aysola

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: May 6, 2022

Obstructive sleep apnea (OSA) is accompanied by fragmentation and altered architecture, which can potentially hinder the glymphatic system, increasing risks for Alzheimer's disease (AD), but status unclear in OSA. Our aim was to investigate system OSA subjects examine relationships between severity, symptoms, indices using diffusion tensor imaging (DTI).We acquired DTI data from 59 62 controls a 3.0-Tesla MRI examined severity symptoms with Pittsburgh Sleep Quality Index (PSQI) Epworth Sleepiness Scale (ESS). Diffusivity maps x-axis (Dxx), y-axis (Dyy), z-axis (Dzz), as well x-y axis (Dxy), y-z (Dyz), x-z (Dxz) were calculated, values projection association fibers extracted, analyses along perivascular space (DTI-ALPS index) performed. The compared groups correlated subjects.Dzz values, derived fiber areas, Dyy Dzz ALPS Dyzmean significantly reduced over controls. Significant correlations emerged Dxy, Dxx, subjects.OSA patients show abnormal function that may contribute increased AD. findings suggest APLS method be used assess patients.

Language: Английский

Citations

47