Altered Brain Glymphatic Flow at Diffusion-Tensor MRI in Rapid Eye Movement Sleep Behavior Disorder

Radiology, Journal Year: 2023, Volume and Issue: 307(5)

Published: May 9, 2023

Background Brain glymphatic dysfunction may contribute to the development of α-synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To examine function brain in isolated rapid eye movement sleep behavior disorder (RBD) its relevance phenoconversion with use diffusion-tensor (DTI) analysis along perivascular space (ALPS). Materials Methods This prospective study included consecutive participants diagnosed RBD, age- sex-matched control participants, Parkinson disease (PD) who were enrolled examined between May 2017 April 2020. All underwent 3.0-T MRI including DTI, susceptibility-weighted susceptibility map–weighted imaging, and/or dopamine transporter using iodine 123–2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane SPECT at time participation. Phenoconversion status α-synucleinopathies was unknown MRI. Participants regularly followed up monitored for any signs The ALPS index reflecting activity calculated by a ratio diffusivities x-axis projection association neural fibers perpendicular them compared according groups Kruskal-Wallis Mann-Whitney U tests. risk RBD evaluated Cox proportional hazards model. Results Twenty (12 men; median age, 73 years [IQR, 66–76 years]), 20 PD included. lower group versus controls (1.53 vs 1.72; P = .001) but showed no evidence difference (1.49; .68). conversion decreased an increasing (hazard ratio, 0.57 per 0.1 increase [95% CI: 0.35, 0.93]; .03). Conclusion DTI-ALPS demonstrated more severe reduction individuals © RSNA, 2023 Supplemental material is available this article. See also editorial Filippi Balestrino issue.

Language: Английский

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Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

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The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

Investigative Radiology, Journal Year: 2023, Volume and Issue: 59(1), P. 1 - 12

Published: March 10, 2023

Abstract The concept of the glymphatic system was proposed more than a decade ago as mechanism for interstitial fluid flow and waste removal in central nervous system. function has been shown to be particularly activated during sleep. Dysfunction implicated several neurodegenerative diseases. Noninvasive vivo imaging is expected useful elucidating pathophysiology these Currently, magnetic resonance most commonly used technique evaluate humans, large number studies have reported. This review provides comprehensive overview investigations human using imaging. can divided into 3 categories, including without gadolinium-based contrast agents (GBCAs), with intrathecal administration GBCAs, intravenous GBCAs. purpose examine not only movement brain parenchyma, but also dynamics perivascular subarachnoid spaces, well parasagittal dura meningeal lymphatics. Recent research even extended include eye inner ear. serves an important update guide future directions.

Language: Английский

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Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: Evidenced by DTI‐ALPS and compared with age‐matched controls

Psychiatry and Clinical Neurosciences, Journal Year: 2023, Volume and Issue: 77(7), P. 401 - 409

Published: April 25, 2023

The diffusion tensor imaging analysis along the perivascular space (ALPS)-index can be used to model glymphatic system in vivo.

Language: Английский

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Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in dementia patients

British Journal of Radiology, Journal Year: 2023, Volume and Issue: 96(1146)

Published: April 17, 2023

Objectives: Dementia is a clinical syndrome caused by multiple etiologies, usually manifests with progressive and diffuse brain dysfunction. The activity of the human glymphatic system was evaluated in cases dementia diffusion tensor image analysis along perivascular space (DTI-ALPS). Methods: We recruited 28 healthy subjects 77 patients, including 38 Alzheimer’s disease (AD),18 mild cognitive impairment (MCI), normal controls (NC) 21 vascular (VCI). All participants underwent DTI scanning. Diffusivities X, Y Z axes were obtained lateral ventricle body plane all subjects. assessed diffusivity spaces, as well projection fibers association fibers, respectively, order to acquire an DTI-ALPS-index correlated them mini mental state examination (MMSE) montreal assessment (MOCA) scores using partial correlation which influence age controlled. Results: AD, MCI, VCI patients showed significantly lower (p < 0.001) compared NC. Besides, group had higher than AD = 0.007). There significant positive between MMSE MOCA (the effect controlled), showing that water spaces associated dementia.The Dzassoc led reduced VCI, while Dxassoc contributed decrease AD. Conclusion: evaluation DTI-ALPS demonstrates decreased DTI-ALPS-index. Different from show drainage disorder rather impairment. Advances knowledge: This article comprehensively covers several types performs comparison MCI

Language: Английский

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Impaired Glymphatic and Meningeal Lymphatic Functions in Patients with Chronic Migraine

Annals of Neurology, Journal Year: 2023, Volume and Issue: 95(3), P. 583 - 595

Published: Dec. 7, 2023

Objective This study was undertaken to investigate migraine glymphatic and meningeal lymphatic vessel (mLV) functions. Methods Migraine patients healthy controls (HCs) were prospectively recruited between 2020 2023. Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index for glymphatics dynamic contrast‐enhanced magnetic resonance imaging parameters (time peak [TTP]/enhancement integral [EI]/mean time enhance [MTE]) para‐superior sagittal (paraSSS)‐mLV or paratransverse sinus (paraTS)‐mLV in episodic (EM), chronic (CM), CM with without medication‐overuse headache (MOH) analyzed. DTI‐ALPS correlations clinical (migraine severity [numeric rating scale]/disability [Migraine Disability Assessment (MIDAS)]/bodily pain [Widespread Pain Index]/sleep quality [Pittsburgh Sleep Quality Index (PSQI)]) examined. Results In total, 175 subjects (112 + 63 HCs) investigated. values lower (median [interquartile range] = 0.64 [0.12]) than EM (0.71 [0.13], p 0.005) HCs [0.09], 0.004). MOH (0.63 [0.07]) had (0.73 [0.12], < 0.001). Furthermore, longer TTP (paraSSS‐mLV: 55.8 [12.9] vs 40.0 [7.6], 0.001; paraTS‐mLV: 51.2 [8.1] 44.0 [3.3], 0.002), EI 45.5 [42.0] 16.1 [9.2], 0.001), MTE 253.7 [6.7] 248.4 [13.8], 252.0 [6.2] 249.7 [1.2], 0.001) patients. The MIDAS ( 0.002) PSQI negatively correlated after Bonferroni corrections q 0.01). Interpretation patients, particularly those MOH, have dysfunctions, which are highly clinically relevant may implicate pathogenesis chronification. ANN NEUROL 2024;95:583–595

Language: Английский

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Association of Cognition and Brain Reserve in Aging and Glymphatic Function Using Diffusion Tensor Image-along the Perivascular Space (DTI-ALPS)

Neuroscience, Journal Year: 2023, Volume and Issue: 524, P. 11 - 20

Published: April 6, 2023

Language: Английский

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The asymmetry of glymphatic system dysfunction in patients with temporal lobe epilepsy: A DTI-ALPS study

Journal of Neuroradiology, Journal Year: 2023, Volume and Issue: 50(6), P. 562 - 567

Published: June 9, 2023

Language: Английский

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Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)

Japanese Journal of Radiology, Journal Year: 2023, Volume and Issue: 41(12), P. 1335 - 1343

Published: June 27, 2023

Language: Английский

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The glymphatic system in migraine and other headaches

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 11, 2024

Abstract Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It made a network perivascular spaces, filled in cerebrospinal interstitial fluid, encompassing penetrating pial vessels communicating with subarachnoid space. separated by blood barrier tissue endfeet astrocytes rich aquaporin 4, membrane protein which controls water flow along Animal models magnetic resonance (MR) studies allowed to characterize glymphatic function determine how its impairment could lead numerous neurological disorders (e.g. Alzheimer’s disease, stroke, sleep disturbances, migraine, idiopathic normal pressure hydrocephalus). This review aims summarize role pathophysiology migraine order provide new ways approaching this disease therapy.

Language: Английский

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