Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 6, 2025

Cancer remains a leading cause of mortality globally and major health burden, with chemotherapy often serving as the primary therapeutic option for patients advanced-stage disease, partially compensating limitations non-curative treatments. However, emergence resistance significantly limits its efficacy, posing clinical challenge. Moreover, heterogeneity mechanisms across cancer types complicates development universally effective diagnostic approaches. Understanding molecular chemoresistance identifying strategies to overcome it are current research focal points. This review provides comprehensive analysis key underlying resistance, including drug efflux, enhanced DNA damage repair (DDR), apoptosis evasion, epigenetic modifications, altered intracellular metabolism, role stem cells (CSCs). We also examine specific causes in highlight various targets involved resistance. Finally, we discuss aiming at overcoming such combination therapies, targeted treatments, novel delivery systems, while proposing future directions this evolving field. By addressing these barriers, lays foundation more therapies aimed mitigating

Language: Английский

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Development and Validation of Monte Carlo Methods for Converay: A Proof-of-Concept Study

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1189 - 1189

Published: March 31, 2025

Radiotherapy technology has undergone significant advancements, driven by the pursuit of improved tumor control probabilities and reduced normal tissue complication probabilities. This been achieved primarily through innovative approaches that prioritize high dose conformity on complex treatment targets. The CONVERAY project introduces a groundbreaking teletherapy system featuring convergent X-ray beam, which enables highly conformal distributions converging photons to focal spot, thereby achieving exceptionally fluence rates. Customized Monte Carlo subroutines have developed simulate particle associated dosimetry effects for device. simulation approach facilitated detailed, step-by-step characterization radiation interaction processes, enabling seamless integration with conventional clinical linear accelerator head. Key physical properties beam comprehensively characterized various configurations, providing solid foundation evaluating corresponding performance. simulations successfully tracked phase state device, characterizing influence individual components photon production. Simulations evaluated performance, confirming device's capability achieve concentrations around spot. Preliminary tests realistic scenarios (intracranial pulmonary irradiations) demonstrated promising spatial concentration within volumes, while gantry rotation significantly conformation. proof-of-concept study prototype provided critical insights into generation beams, validating ability its primary objective. Notably, results reveal potential demonstrating

Language: Английский

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Surgical Outcomes of Minimally Invasive Lung Resection in Nonagenarians: A Retrospective Analysis of Seven Patients at a Single Institution

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

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A SiC Photo-Conductive Switch-Based Pulse Generator with Nanoseconds and High Voltage for Liver Cancer Cells Ablation Therapy

Electronics, Journal Year: 2024, Volume and Issue: 13(23), P. 4816 - 4816

Published: Dec. 6, 2024

Electroporation ablation, as an innovative cancer treatment, not only preserves the structure and function of affected organs but also significantly reduces surgical risks, offers patients a safer more effective therapeutic option, demonstrates immense potential in field oncology. This paper presents design high-voltage nanosecond pulse generator triggered by silicon carbide (SiC) photoconductive switch. The is capable stably outputting adjustable voltages ranging from 10 kV to 15 kV, with widths precisely controlled between nanoseconds, operating frequency 1 Hz Hz. device enables instant activation deactivation during enhancing efficiency strong electric applications preventing overtreatment due delayed shutdown. introduces basic principles this novel SiC switch-triggered reports on impact device-related parameters ablation effect hepatocellular carcinoma cells through cell experiments. Under optimal parameters, CCK8 results show that number viable 0.7% untreated control group after 12 h subculture following ablation. These findings hold significant importance for expanding application areas devices.

Language: Английский

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