Complex Issues of Cardiovascular Diseases,
Journal Year:
2023,
Volume and Issue:
12(4S), P. 162 - 172
Published: Dec. 29, 2023
Highlights
The
review
presents
up-to-date
data
on
the
contribution
of
type
2
diabetes
mellitus
to
development
and
progression
heart
failure.
highlights
key
mechanisms
pathogenesis
failure
associated
with
changes
in
energy
metabolism
cardiomyocytes.
Abstract
Type
is
one
main
risk
factors
that
significantly
worsen
prognosis
increases
probability
fatal
cardiovascular
events.
diabetic
patients
involves
a
great
number
for
rapid
atherosclerosis,
as
well
numerous
combinations
neurohumoral,
molecular
histological
not
atherogenesis,
which
interconnection
results
complications
decompensation.
This
discusses
underlying
mellitus,
particular,
special
attention
paid
cardiomyocyte
metabolism,
death,
significance
epigenetic
chronic
Essays in Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Abstract
Heart
failure
(HF)
represents
a
multifaceted
clinical
syndrome
characterized
by
the
heart’s
inability
to
pump
blood
efficiently
meet
body’s
metabolic
demands.
Despite
advances
in
medical
management,
HF
remains
major
cause
of
morbidity
and
mortality
worldwide.
In
recent
years,
considerable
attention
has
been
directed
toward
understanding
molecular
mechanisms
underlying
pathogenesis,
with
particular
focus
on
role
AMP-activated
protein
kinase
(AMPK)
O-GlcNAcylation.
This
review
comprehensively
examines
current
AMPK
O-GlcNAcylation
signalling
pathways
HF,
emphasizing
their
interplay
dysregulation.
We
delve
into
intricate
which
contribute
cardiac
energetics,
metabolism,
remodelling,
highlighting
preclinical
studies
that
have
explored
novel
therapeutic
interventions
targeting
these
pathways.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(6), P. 664 - 664
Published: May 22, 2024
The
circulatory
system
is
a
closed
conduit
throughout
the
body
and
consists
of
two
parts
as
follows:
cardiovascular
lymphatic
system.
Hematological
malignancies
usually
grow
multiply
in
system,
directly
or
indirectly
affecting
its
function.
These
include
multiple
myeloma,
leukemia,
lymphoma.
O-linked
β-N-acetylglucosamine
(O-GlcNAc)
transferase
(OGT)
regulates
function
stability
substrate
proteins
through
O-GlcNAc
modification.
Abnormally
expressed
OGT
strongly
associated
with
tumorigenesis,
including
hematological
malignancies,
colorectal
cancer,
liver
breast
prostate
cancer.
In
cells,
can
assemble
variety
to
form
complexes
exercise
related
biological
functions,
such
OGT/HCF-1,
OGT/TET,
NSL,
then
regulate
glucose
metabolism,
gene
transcription,
cell
proliferation,
other
processes,
thus
development
malignancies.
This
review
summarizes
involved
assembly
cells
role
Unraveling
complex
network
regulated
by
will
facilitate
better
understanding
hematologic
malignancy
progression.
Journal of Cardiovascular Pharmacology,
Journal Year:
2022,
Volume and Issue:
80(2), P. 236 - 250
Published: May 13, 2022
Abstract:
As
a
critical
regulatory
molecule,
receptor-interacting
protein
kinase
3
(RIPK3)
can
mediate
the
signaling
pathway
of
programmed
necrosis.
Calcium/calmodulin-dependent
II
(CaMKII)
has
been
proved
as
new
substrate
for
RIPK3-induced
necroptosis.
In
this
study,
we
aimed
to
investigate
mechanism
RIPK3
on
phenylephrine
(PE)-induced
cardiomyocyte
hypertrophy.
Cardiomyocyte
hypertrophy
was
induced
by
exposure
PE
(100
μM)
48
hours.
Primary
cardiomyocytes
were
pretreated
with
inhibitor
GSK′872
(10
μM),
and
siRNA
used
deplete
intracellular
expression
RIPK3.
The
indexes
related
myocardial
hypertrophy,
cell
injury,
necroptosis,
CaMKII
activation,
gene
expression,
oxidative
stress,
mitochondrial
membrane
potential
measured.
We
found
that
after
stimulated
PE,
expressions
markers,
atrial
brain
natriuretic
peptides
(ANP
BNP),
increased,
release
lactate
dehydrogenase
level
adenosine
triphosphate
(ATP)
decreased,
oxidation
phosphorylation
levels
CaMKIIδ
alternative
splicing
disturbed.
However,
both
depletion
could
reduce
dysfunction,
inhibit
activation
finally
alleviate
addition,
pretreatment
also
lessen
accumulation
reactive
oxygen
species
(ROS)
stabilize
mitochondria.
These
results
indicated
targeted
inhibition
suppress
necroptosis
leading
alleviated
Collectively,
our
findings
provided
valuable
insights
into
clinical
treatment
hypertrophic
cardiomyopathy.
Complex Issues of Cardiovascular Diseases,
Journal Year:
2023,
Volume and Issue:
12(4S), P. 162 - 172
Published: Dec. 29, 2023
Highlights
The
review
presents
up-to-date
data
on
the
contribution
of
type
2
diabetes
mellitus
to
development
and
progression
heart
failure.
highlights
key
mechanisms
pathogenesis
failure
associated
with
changes
in
energy
metabolism
cardiomyocytes.
Abstract
Type
is
one
main
risk
factors
that
significantly
worsen
prognosis
increases
probability
fatal
cardiovascular
events.
diabetic
patients
involves
a
great
number
for
rapid
atherosclerosis,
as
well
numerous
combinations
neurohumoral,
molecular
histological
not
atherogenesis,
which
interconnection
results
complications
decompensation.
This
discusses
underlying
mellitus,
particular,
special
attention
paid
cardiomyocyte
metabolism,
death,
significance
epigenetic
chronic
