Relationship between hypothalamic pituitary thyroid function and bone mineral density NHANES 2007-2012 DOI Creative Commons

Lizhen Cao,

Jing Shu, Yuanyuan Yao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Introduction:Prior research has indicated a correlation between hypothalamic-pituitary endocrine secretion and bone health. However, the relationship thyroid hormone levels lumbar spine density in adults remains incompletely understood. The objective of present study was to examine this assess moderating effects factors such as gender, age, depressive symptoms on it. Methods:Cross-sectional analyses were conducted using data from National Health Nutrition Examination Survey (NHANES), 2007 2012. Weighted linear regression models multiple logistic employed evaluate indicators function 4996 aged 20-80 years. Additionally, investigated effect hormones depressed adults. Results conclusions:In adults, significant negative observed FT3 levels, but not with any other hormones. TT3, TT4, Tg found be interactive regard gender. No interaction age Subgroup revealed that inverse mineral (BMD) free triiodothyronine (FT3) exclusive younger statistically older In fully adjusted model, BMD TT4 adult males (p=0.027), whereas no identified females. significantly negatively correlated FT4 non-depressed patients (p=0.040, p=0.027). it although correlate both depression BMD, do cause changes solely because states. Therefore, further comprehensive is required elucidate specific mechanism hypothalamic-pituitary-thyroid

Language: Английский

Risk factors for osteoporosis in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis DOI Creative Commons
Wenhao Su,

Hairong Jia,

Yang Luo

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0319602 - e0319602

Published: Feb. 27, 2025

Background Osteoporosis is a prevalent chronic result of diabetes. susceptibility raised by unstable blood glucose levels, oxidative stress, hormonal abnormalities, and other factors. Currently, there no systematic review addressing the risk factors osteoporosis in This study intends to systematically assess current related diabetic (DOP) provide suggestions for improvement therapy approaches. Methods analysis We will search five English literature databases (PubMed, Embase, Web Science, CINAHL, Cochrane Library) three Chinese (CNKI, WanFang, SinoMed) from starting point until December 31, 2024. perform examination meta-analysis cohort case-control studies identify all population-based osteoporosis. Two researchers independently publication, extract data, evaluate quality potential biases present study. utilize RevMan V.5.4 software STATA 16.0 data analysis. The included be assessed using Newcastle Ottawa Quality Assessment Instrument (NOS). If heterogeneity higher than 50%, we subgroup sensitivity probable sources heterogeneity. assessment publication bias conducted funnel plot. Furthermore, employ Grading Recommendations Assessment, Development, Evaluation (GRADE) evidence each exposure outcome. Discussion protocol aims investigate variables associated with DOP. summarize knowledge about influencing strive assist physicians more extensive references decision-making facilitate implementation effective prevention strategies Registration has been registered PROSPERO ( CRD42024602637 ).

Language: Английский

Citations

0
Relationship between hypothalamic pituitary thyroid function and bone mineral density NHANES 2007-2012 DOI Creative Commons

Lizhen Cao,

Jing Shu, Yuanyuan Yao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Introduction:Prior research has indicated a correlation between hypothalamic-pituitary endocrine secretion and bone health. However, the relationship thyroid hormone levels lumbar spine density in adults remains incompletely understood. The objective of present study was to examine this assess moderating effects factors such as gender, age, depressive symptoms on it. Methods:Cross-sectional analyses were conducted using data from National Health Nutrition Examination Survey (NHANES), 2007 2012. Weighted linear regression models multiple logistic employed evaluate indicators function 4996 aged 20-80 years. Additionally, investigated effect hormones depressed adults. Results conclusions:In adults, significant negative observed FT3 levels, but not with any other hormones. TT3, TT4, Tg found be interactive regard gender. No interaction age Subgroup revealed that inverse mineral (BMD) free triiodothyronine (FT3) exclusive younger statistically older In fully adjusted model, BMD TT4 adult males (p=0.027), whereas no identified females. significantly negatively correlated FT4 non-depressed patients (p=0.040, p=0.027). it although correlate both depression BMD, do cause changes solely because states. Therefore, further comprehensive is required elucidate specific mechanism hypothalamic-pituitary-thyroid

Language: Английский

Citations

0