New insights into the genomic information of an overlooked human pathogen: Bartonella rochalimae causative agent of Carrion’s disease DOI Creative Commons

Giovanna Mendoza-Mujica,

Karen Daphne Calvay-Sanchez, Yanina Zarate-Sulca

et al.

PLoS neglected tropical diseases, Journal Year: 2025, Volume and Issue: 19(4), P. e0013040 - e0013040

Published: April 17, 2025

The Bartonella genus includes over twenty species, most transmitted by arthropods and possibly eleven related to human diseases, though some currently lack specific vectors or hosts. rochalimae , a Gram-negative pleomorphic bacterium, was first isolated in 2007 from woman who traveled Peru developed Carrion’s disease-like symptoms. Hence, this study aims report on bacterial isolates patients diagnosed with disease, which were found be caused B. rather than bacilliformis characterize the genomic aspects of as pathogen. Five strains identified using pangenomic phylogenetic analysis. Additional analyses included core clade-specific genes, gene ontology (GO), virulence factors (VF), subcellular localization. This five regions Ancash, Cajamarca, Huánuco Peru, suggesting regional circulation. findings emphasize importance further research functions its role outbreak developments, highlighting improved diagnostics enhanced surveillance.

Language: Английский

New insights into the genomic information of an overlooked human pathogen: Bartonella rochalimae causative agent of Carrion’s disease DOI Creative Commons

Giovanna Mendoza-Mujica,

Karen Daphne Calvay-Sanchez, Yanina Zarate-Sulca

et al.

PLoS neglected tropical diseases, Journal Year: 2025, Volume and Issue: 19(4), P. e0013040 - e0013040

Published: April 17, 2025

The Bartonella genus includes over twenty species, most transmitted by arthropods and possibly eleven related to human diseases, though some currently lack specific vectors or hosts. rochalimae , a Gram-negative pleomorphic bacterium, was first isolated in 2007 from woman who traveled Peru developed Carrion’s disease-like symptoms. Hence, this study aims report on bacterial isolates patients diagnosed with disease, which were found be caused B. rather than bacilliformis characterize the genomic aspects of as pathogen. Five strains identified using pangenomic phylogenetic analysis. Additional analyses included core clade-specific genes, gene ontology (GO), virulence factors (VF), subcellular localization. This five regions Ancash, Cajamarca, Huánuco Peru, suggesting regional circulation. findings emphasize importance further research functions its role outbreak developments, highlighting improved diagnostics enhanced surveillance.

Language: Английский

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