Multi-omics insights into the response of the gut microbiota and metabolites to albendazole deworming in captive Rhinopithecus brelichi DOI Creative Commons
Xue Qin,

Jincheng Han,

Xi Li

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Parasite infection and deworming treatment affect the host gut microbiota. Exploring response mechanism of microbiota in Rhinopithecus brelichi (R. brelichi) to albendazole is great value for protecting this critically endangered species. This study used metataxonomics metabolomics explore responses metabolites R. treatment. The results showed that significantly reduced eggs per gram feces (EPG). 16S rRNA gene sequencing richness diversity after were increased. Meanwhile, also changed composition At genus level, Christensenellaceae R7 group, UCG 002, 005, uncultured rumen bacterium, Rikenellaceae RC9 group enriched pre-deworming samples. Unclassified Muribaculaceae, Prevotella 9, Bacteroides post-deworming Metabolomics analysis revealed relative abundance 382 out 1,865 significant differences between pre- Among them, 103 annotated based on HMDB mainly classified into Prenol lipids, Carboxylic acids derivatives, Organooxygen compounds, etc. KEGG enrichment result indicated these involved energy, amino acid, lipid, purine metabolism. Correlation unclassified whose abundances upregulated treatment, positively correlated with Kaempferol, 5,7-Dihydroxy-3-methoxy-4'-prenyloxyflavone, Purpurin, Rhein, which have anti-parasitic activities. a downregulated was not only negatively above four metabolites, but Retinyl beta-glucuronide, storage form vitamin A, CDP-Choline, increases host's susceptibility Entamoeba histolytica Plasmodium falciparum. emphasizes has an impact metabolic functions brelichi. By exploiting correlations differential potential probiotics or prebiotics can be explored, thereby enhancing efficiency reducing its side effects.

Language: Английский

Multi-omics insights into the response of the gut microbiota and metabolites to albendazole deworming in captive Rhinopithecus brelichi DOI Creative Commons
Xue Qin,

Jincheng Han,

Xi Li

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Parasite infection and deworming treatment affect the host gut microbiota. Exploring response mechanism of microbiota in Rhinopithecus brelichi (R. brelichi) to albendazole is great value for protecting this critically endangered species. This study used metataxonomics metabolomics explore responses metabolites R. treatment. The results showed that significantly reduced eggs per gram feces (EPG). 16S rRNA gene sequencing richness diversity after were increased. Meanwhile, also changed composition At genus level, Christensenellaceae R7 group, UCG 002, 005, uncultured rumen bacterium, Rikenellaceae RC9 group enriched pre-deworming samples. Unclassified Muribaculaceae, Prevotella 9, Bacteroides post-deworming Metabolomics analysis revealed relative abundance 382 out 1,865 significant differences between pre- Among them, 103 annotated based on HMDB mainly classified into Prenol lipids, Carboxylic acids derivatives, Organooxygen compounds, etc. KEGG enrichment result indicated these involved energy, amino acid, lipid, purine metabolism. Correlation unclassified whose abundances upregulated treatment, positively correlated with Kaempferol, 5,7-Dihydroxy-3-methoxy-4'-prenyloxyflavone, Purpurin, Rhein, which have anti-parasitic activities. a downregulated was not only negatively above four metabolites, but Retinyl beta-glucuronide, storage form vitamin A, CDP-Choline, increases host's susceptibility Entamoeba histolytica Plasmodium falciparum. emphasizes has an impact metabolic functions brelichi. By exploiting correlations differential potential probiotics or prebiotics can be explored, thereby enhancing efficiency reducing its side effects.

Language: Английский

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