Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(5), P. 162 - 162
Published: Sept. 19, 2024
The
present
study
aimed
to
analyze
the
antifungal,
antioxidant,
and
irritant
potential
of
citronella
oil,
both
isolated
combined
with
caffeic
acid
phenethyl
ester
(CAPE),
for
topical
oral
candidiasis.
antioxidant
was
evaluated
using
two
methods,
DPPH
test
reducing
power
(FRAP),
while
solutions
assessed
through
hen’s
egg
chorioallantoic
membrane
(HET-CAM).
(IC50)
values
CITRO
III
+
CAPE
combination
were
32
±
9
mg/mL,
CAPE,
13
3
mg/mL.
results
from
FRAP
method
revealed
a
low
iron-reducing
1.25
mg/mL
0.0775
(CITRO
III),
showing
no
significant
difference
compared
solution
0.15
CAPE.
antibacterial
activity
in
vitro
against
microorganisms
methods:
microdilution
biofilm
assay.
showed
that
MIC
MFC
0.5
at
tested
times
(24
h
48
h).
For
0.031
assay,
compounds
combinations
1
min
6
significantly
different
controls
(p
<
0.05).
Furthermore,
HET-CAM
demonstrated
absence
irritability.
Based
on
these
premises,
antifungal
actions,
irritability
proven.
Moreover,
this
work
presents
natural
interest
pharmaceutical
industry.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(12), P. e33150 - e33150
Published: June 1, 2024
In
the
previous
study,
synthesis
and
characterization
of
4-(3-fluorophenyl)-3-thiosemicarbazide
benzaldehyde
derivatives
based
thiosemicarbazone
ligands
their
Co(II),
Ni(II),
Cu(II),
Zn(II)
complexes
were
carried
out
to
evaluate
malarial
oxidant
inflammatory
inhibition
abilities,
demonstrating
that
these
compounds
have
robust
efficacy
for
ailments.
present
research,
find
a
combating
agent
against
breast
cancer,
tuberculosis,
bacterial
fungal
ailments,
tested
through
MTT,
microplate
alamar
blue
serial
dilution
protocols.
ADMET
DFT
investigation
analyzed
highly
bioactive
(2,
7–10)
give
new
insight
about
compound's
reactivity,
stability
drug
likeness
properties.
Furthermore,
activity
results
shows
ligand
(2)
its
demonstrate
greater
compared
(1)
complexes.
The
Cu(II)
(9)
(10)
observed
as
efficient
cancer
(MCF-7
cell
line),
TB
(H37Rv
strain),
ailments
in
comparison
standard
drugs
with
0.029
±
0.001
μM
IC50
value
anticancer
0.0034
0.0017
μmol/mL
MIC
anti-tuberculosis
activity.
molecular
docking
investigation,
various
kind
binding
interactions
lowest
affinity
(against
4RJ3
(−10.0
kcal/mol),
2VCJ
(−7.9
kcal/mol))
(−7.8
−8.3
kcal/mol
5V3Y
3PTY
protein)
support
bioactivity.
This
research
highlights
pharmaceutical
importance
transition
metal
having
thiosemicarbazones,
presenting
significant
approach
discovery
potent
anti-infectious
agent.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(20), P. 14051 - 14067
Published: Jan. 1, 2024
Synthesis
of
mono-
and
bis-thiosemicarbazones
4a–h
5a–h
isatin–triazole
hybrids
3a
3b
in
turn
accessed
via
CuAAC,
their
DFT
studies
potential
as
phosphoinositide
3-kinase
(PI3K)
inhibitors
has
been
evaluated
this
study.
