Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities DOI Creative Commons

Yanmei Liao,

Fei Lv,

Tianwen Quan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

The liver is the largest, important organ and site for essential biochemical reactions in human body. It has function to detoxify toxic substances synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity mortality worldwide, creating substantial economic burden. Oxidative stress, excessive inflammation, dysregulated energy metabolism significantly contributed diseases. Therefore, discovery novel therapeutic drugs treatment are urgently required. For centuries, flavonoids their preparations which have beneficial health effects chronic been used treat various illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins chalcones. primary objective this review assess efficacy safety flavonoids, from clinical point view considering clinically relevant end-points. We summarized recent progress research hepatoprotective molecular mechanisms different bioactive ingredients also outlined networks underlying signaling pathways. Further pharmacology toxicology will contribute development natural products derivatives as medicines with alluring prospect application.

Language: Английский

Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities DOI Creative Commons

Yanmei Liao,

Fei Lv,

Tianwen Quan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

The liver is the largest, important organ and site for essential biochemical reactions in human body. It has function to detoxify toxic substances synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity mortality worldwide, creating substantial economic burden. Oxidative stress, excessive inflammation, dysregulated energy metabolism significantly contributed diseases. Therefore, discovery novel therapeutic drugs treatment are urgently required. For centuries, flavonoids their preparations which have beneficial health effects chronic been used treat various illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins chalcones. primary objective this review assess efficacy safety flavonoids, from clinical point view considering clinically relevant end-points. We summarized recent progress research hepatoprotective molecular mechanisms different bioactive ingredients also outlined networks underlying signaling pathways. Further pharmacology toxicology will contribute development natural products derivatives as medicines with alluring prospect application.

Language: Английский

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