Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 6, 2025
Metabolic
Associated
Fatty
Liver
Disease
(MAFLD)
is
becoming
a
major
global
health
concern
due
to
its
links
with
obesity,
insulin
resistance,
and
cardiovascular
risk.
This
randomized
clinical
trial
assessed
the
effects
of
combining
time-restricted
feeding
(TRF;
16/8)
Lacto-Ovo-Vegetarian
(LOV)
diet
on
various
factors
in
overweight
obese
patients
MAFLD.
Forty-six
participants
were
randomly
assigned
either
intervention
group
(TRF
LOV
diet)
or
control
group,
21
completing
12-week
study
each
group.
The
showed
significant
reductions
weight
(-8.07
±
4.31
kg),
BMI
(-2.70
1.32
kg/m2),
waist
circumference
(-8.00
4.06
cm),
as
well
ALT
(-17.14
14.33
U/L),
GGT
(-21.09
24.06
Index
(-26.90
15.81),
levels
(-3.89
4.69
mU/L),
TNF-α
(-11.85
12.52
pg/mL)
compared
(all
P
<
0.05).
Lipid
profiles
also
improved
reduction
triglycerides
(-46.85
54.55
mg/dL)
an
increase
HDL-C
(3.91
5.07
(P
These
findings
imply
that
TRF
combined
enhances
metabolic
markers,
liver
health,
loss,
thus
potentially
offering
practical
dietary
approach
for
managing
Further
long-term
studies
are
necessary
validate
these
results
investigate
their
applications.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4673 - 4673
Published: May 14, 2025
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
public
health
concern
that
constantly
expanding,
with
fast-growing
prevalence,
and
it
affects
about
quarter
of
the
world’s
population.
This
condition
significant
risk
factor
for
cardiovascular,
hepatic,
oncologic
diseases,
such
as
hypertension,
hepatoma,
atherosclerosis.
Sarcopenia
was
long
considered
to
be
an
aging-related
syndrome,
but
today,
acknowledged
secondarily
related
chronic
diseases
metabolic
cardiovascular
conditions,
liver
among
other
comorbidities
associated
insulin
resistance
inflammation,
besides
inactivity
poor
nutrition.
The
physiopathology
involving
MAFLD
sarcopenia
has
still
not
been
solved.
Inflammation,
oxidative
stress,
mitochondrial
dysfunction,
seem
some
keys
this
relationship
since
hormone
target
mainly
skeletal
muscle.
review
aimed
comprehensively
discuss
main
physiological
pathways
involved
in
these
conditions.
are
interconnected
by
complex
network
pathophysiological
mechanisms,
resistance,
muscle
tissue
production
capacity,
inflammatory
state,
which
contributors
relationship.
In
addition,
clinical
analysis,
patients
manifest
more
severe
hepatitis
fibrosis
when
compared
only
MAFLD.
These
patients,
both
disorders,
also
present
improvement
their
treated
sarcopenia,
reinforcing
association
between
them.
Lifestyle
changes
accompanied
non-pharmacological
interventions,
dietary
therapy
increased
physical
activity,
undoubtedly
improve
scenario.
In
the
past
thirty
years,
childhood
obesity
rates
have
risen
significantly
worldwide,
affecting
over
340
million
children
in
affluent
nations.
This
surge
is
intricately
tied
to
metabolic
disorders,
notably
insulin
resistance,
type
2
diabetes
mellitus
(T2DM),
and
continually
evolving
spectrum
of
metabolic-associated
(dysfunction)
steatotic
liver
disease
(MASLD).
review
underscores
alarming
escalation
delves
comprehensively
into
dynamic
changes
nomenclature
surrounding
diverse
conditions
hepatic
steatosis,
from
initial
recognition
non-alcoholic
fatty
(NAFLD)
progressive
evolution
MASLD.
Moreover,
it
emphasizes
crucial
role
pediatric
endocrinologists
thoroughly
accurately
investigating
MASLD
onset
with
T2DM
where
each
condition
influences
exacerbates
progression
other.
The
critically
highlights
inadequacies
current
screening
strategies
diagnosis,
stressing
need
for
a
paradigm
shift.
A
proposed
solution
involves
integration
magnetic
resonance
imaging
assessment
diagnostic
arsenal
showing
insufficient
glycaemic
control
weight
loss
post-T2DM
thereby
complementing
conventional
enzyme
testing.
holistic
approach
aims
enhance
precision,
fostering
improved
outcomes
this
vulnerable
high-risk
population.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(6), P. 2350 - 2361
Published: June 14, 2024
The
prevention
and
early
diagnosis
of
liver
cancer
remains
a
global
medical
challenge.
During
the
malignant
transformation
hepatocytes,
variety
oncogenic
cellular
signalling
molecules,
such
as
novel
high
mobility
group-Box
3,
angiopoietin-2,
Golgi
protein
73,
glypican-3,
Wnt3a
(a
molecule
in
Wnt/β-catenin
pathway),
secretory
clusterin,
can
be
expressed
secreted
into
blood.
These
molecules
are
derived
from
different
pathways
may
not
only
participate
hepatocytes
but
also
become
diagnostic
indicators
hepatocarcinogenesis
or
specific
targeted
for
hepatocellular
carcinoma
therapy.
This
article
reviews
recent
progress
study
several
sensitive
biomarkers
monitoring
hepatocarcinogenesis.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9924 - 9924
Published: Sept. 14, 2024
In
the
past
thirty
years,
childhood
obesity
rates
have
risen
significantly
worldwide,
affecting
over
340
million
children
in
affluent
nations.
This
surge
is
intricately
tied
to
metabolic
disorders,
notably
insulin
resistance,
type
2
diabetes
mellitus
(T2DM),
and
continually
evolving
spectrum
of
metabolic-associated
(dysfunction)
steatotic
liver
disease
(MASLD).
review
underscores
alarming
escalation
delves
comprehensively
into
dynamic
changes
nomenclature
surrounding
diverse
conditions
hepatic
steatosis,
from
initial
recognition
non-alcoholic
fatty
(NAFLD)
progressive
evolution
MASLD.
Moreover,
it
emphasizes
crucial
role
pediatric
endocrinologists
thoroughly
accurately
investigating
MASLD
onset
with
T2DM,
where
each
condition
influences
exacerbates
progression
other.
critically
highlights
inadequacies
current
screening
strategies
diagnosis,
stressing
need
for
a
paradigm
shift.
A
proposed
solution
involves
integration
magnetic
resonance
imaging
assessment
diagnostic
arsenal
showing
insufficient
glycemic
control
weight
loss
post-T2DM
thereby
complementing
conventional
enzyme
testing.
holistic
approach
aims
enhance
precision,
fostering
improved
outcomes
this
vulnerable
high-risk
population.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(12), P. 3269 - 3269
Published: Dec. 10, 2023
The
association
of
endotoxemia
with
metabolic
syndrome
(MS)
and
low-grade
inflammation
in
type
1
diabetes
(T1D)
is
little-studied.
We
investigated
the
levels
lipopolysaccharide
(LPS),
lipopolysaccharide-binding
protein
(LBP),
endogenous
anti-endotoxin
core
antibodies
(EndoCAb
IgG
IgM)
high-sensitivity
C-reactive
(hsCRP)
74
T1D
patients
different
MS
statuses
33
control
subjects.
Within
group,
31
had
MS.
These
subjects
higher
LPS
compared
to
without
(MS
0.42
(0.35-0.56)
or
no
0.34
(0.3-0.4),
p
=
0.009).
was
associated
LPS/HDL
(OR
6.5
(2.1;
20.0),
0.036)
EndoCAb
IgM
0.32
(0.11;
0.93),
T1D.
LBP
(β
0.30
(0.09;
0.51),
0.005),
0.29
(0.07;
0.008)
ratio
0.19
(0.03;
0.41,
0.084)
were
significantly
log-transformed
hsCRP
Higher
observed
(p
0.002
0.091,
respectively).
In
contrast
situation
did
not
correlate
LBP,
EndoCAb,
leukocytes
HDL
To
conclude,
inflammation,
a
distinct
response
