Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that’ s the question DOI
Kwok M. Ho, Anna Lee, William Ka Kei Wu

et al.

Journal of Geriatric Cardiology, Journal Year: 2023, Volume and Issue: 20(11), P. 813 - 823

Published: Nov. 1, 2023

The aging population is an important issue around the world especially in developed countries. Although medical advances have substantially extended life span, same cannot be said for duration of health span. We are seeing increasing numbers elderly people who frail and/or multiple chronic conditions; all these can affect quality as well increase burden on healthcare system. Aging mechanistically related to common conditions such diabetes mellitus, ischemic heart disease, cognitive decline, and frailty. A recently accepted concept termed 'Accelerated Biological Aging' diagnosed when a person's biological age-as measured by biomarkers DNA methylation-is older than their corresponding chronological age. Taurine, conditionally essential amino acid, has received much attention past few years. substantial number animal studies provided strong scientific foundation suggesting that this acid improve cellular metabolic health, including blood glucose control, so it been labelled one 'longevity acids'. In review article, we propose rationale adequately powered randomized-controlled-trial (RCT) needed confirm whether taurine meaningfully microbiome This trial should incorporate certain elements order provide much-needed evidence guide doctors, also community at large, determine promising inexpensive useful improving human health.

Language: Английский

Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study DOI Creative Commons
Simon Nusinovici, Tyler Hyungtaek Rim, Hengtong Li

et al.

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: unknown, P. 100593 - 100593

Published: Sept. 1, 2024

Language: Английский

Citations

9
Association between surgeon procedure volume and reoperation rates for penile prosthesis implantation DOI Creative Commons
Juan J. Andino,

Navid Leelani,

Ryoko Sato

et al.

The Journal of Sexual Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1
Better Life’s Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007–2010 data DOI Creative Commons
Dongzhe Wu,

Chaoyi Qu,

Peng Huang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

Objective To investigate the relationship between Life’s Essential 8 (LE8) and Phenotypic Age Acceleration (PhenoAgeAccel) in United States adults to explore impact of LE8 on phenotypic biological aging, thereby providing references for public health policies education. Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) conducted 2007 2010, this cross-sectional study analyzed 7,339 aged 20 above. Comprehensive assessments LE8, PhenoAgeAccel, research covariates were achieved through integration Demographics Data, Dietary Laboratory Questionnaire Data derived NHANES. Weighted generalized linear regression models restricted cubic spline plots employed analyze non-linear associations along with gender subgroup analysis interaction effect testing. Results (1) Dividing 2007–2010 NHANES cohort into quartiles based unveiled significant disparities age, gender, race, body mass index, education level, marital status, poverty-income ratio, smoking drinking statuses, diabetes, hypertension, hyperlipidemia, various markers ( p < 0.05). Mean cell volume demonstrated no intergroup differences > (2) The weighted revealed a more pronounced negative correlation higher (Q2, Q3, Q4) PhenoAgeAccel compared lowest quartile both crude fully adjusted This trend was statistically 0.001) full adjustment model. Gender within exhibited male female participants, tests demonstrating results 0.001 males = females). (3) Restricted (RCS) elucidated trends overall subgroups (4) Interaction denoted effects studied stratified variables such as status However, index diabetes manifested 0.05), suggesting that influence might vary depending an individual’s BMI status. Conclusion study, 2007–2010, has emphasizing importance maintaining healthy lifestyle slowing down aging process. Despite limitations posed by study’s design geographical constraints, these findings provide scientific basis development focused practices. Future should further causal mechanisms underlying consider cross-cultural comparisons enhance our understanding aging.

Language: Английский

Citations

4
Prevalence and Sociodemographic Correlates of Chronic Pain Among a Nationally Representative Sample of Older Adults in the United States DOI
Lisa R. LaRowe,

Christine Miaskowski,

Andrea Mayfield

et al.

Journal of Pain, Journal Year: 2024, Volume and Issue: 25(10), P. 104614 - 104614

Published: June 25, 2024

Language: Английский

Citations

4
The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS DOI Creative Commons

Weiyi Shi,

Zihong Cai,

Ren Xiao-xu

et al.

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(3), P. 100488 - 100488

Published: Jan. 15, 2025

This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged older adults in China, as well assess relationship SUA trajectories risk of aging. We utilized data from China Health Retirement Longitudinal Study (CHARLS), selecting participants who completed follow-ups 2011 2015. Biological age was estimated using Klemera-Doubal method, determined by calculating difference an individual's biological their chronological age. Logistic regression models were employed analyze baseline levels, trajectories, aging, adjusting for potential confounding factors. A total 3,520 (average 59.00 years) included. The results indicated a significant linear positive correlation levels Compared group with lowest those highest had markedly increased (OR = 1.5, 95% CI: 1.23-1.83, P < 0.001). Further longitudinal analysis suggested that maintaining low level associated reduction indicates elevated constitute factor adults. Maintaining at low-level help slow down These findings highlight importance monitoring this demographic, providing scientific basis developing interventions delay

Language: Английский

Citations

0
Exploring new markers for biological aging from bioimpedance analysis and cognitive functions in older adults DOI Creative Commons

Dieu Ni Thi Doan,

Boncho Ku,

Kahye Kim

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Aging is a complex process that affects human health and lifespan. While chronological age (CA) significant risk factor for many diseases, it does not fully capture biological changes influence span. This study explores cognitive measures using the Seoul Neuropsychological Screening Battery body composition profiles as potential (BA) markers in older population. Multiple linear regression, principal component analysis (PCA), Klemera–Doubal (KDM) methods were used to construct sex-specific BA formulas from 296 healthy individuals (160 women, 136 men, mean age: 70.3 years). The applied new cohort of 708 diseased people (376 332 73.5 years) generate BAs each sex. Subsequently, we compared classification power CA, BAs, selected variables when differentiating group comorbidity cohort, with sex stratification. As result, found PCA KDM significantly higher than CA but comparable group. yielded accuracies alone. Notably, frontal executive domain score reactance emerged two promising aging. These findings suggest assessments offer more accurate reflection A wider range needed generalize these findings.

Language: Английский

Citations

0
Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults DOI Creative Commons

Lauren Opsasnick,

Wei Zhao, Lauren Schmitz

et al.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: 45, P. 100994 - 100994

Published: April 13, 2025

Psychosocial factors, including cumulative psychosocial stress and loneliness, have been linked to epigenetic aging in older adults. Further, depressive symptoms established relationships with both factors aging. However, it is not known whether mediate the association between aging.We conducted linear regression models examine associations stress, five age acceleration (AA) measures estimated by DNA methylation a multi-racial/ethnic sample of 2681 adults from Health Retirement Study (mean age: 70.4 years). For all identified associations, we tested for effect modification sex educational attainment performed mediation analysis characterize role on these associations.Psychosocial were each associated at least one measure AA (FDR q < 0.05). observed interactions DunedinPACE, as well loneliness GrimAA, PhenoAA, females individuals without college degree appearing more sensitive effects Depressive mediated 24 % 35 HannumAA, 40 37 GrimAA respectively. this study may help elucidate relationship aging, which critical understanding biological mechanisms through contribute age-related disease.

Language: Английский

Citations

0
Shaping the future of geriatric chronic pain care: a research agenda for progress DOI
Lisa R. LaRowe, Tony V Pham, Claire Szapary

et al.

Pain Management, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 17, 2025

Chronic pain is highly prevalent among older adults and its burden will become increasingly significant as our population ages. Yet, chronic often undertreated in this vulnerable due to various barriers health care delivery. To improve geriatric management, we assert that require a dedicated research agenda designed inform the development, testing, implementation of treatments account for unique vulnerabilities healthcare needs population. Specifically, propose following four areas immediate attention better serve with pain: (1) equity, (2) substance use, (3) dyadic interventions, (4) digital health. Our proposed aims create more robust comprehensive body evidence ultimately transform advance management.

Language: Английский

Citations

0
A comparison between radiomic biological age and chronological age in estimating kidney function DOI Creative Commons
Radin Alikhani, Steven R. Horbal, Manjunath P. Pai

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

Abstract Accurate kidney function estimation hinges on essential markers of age and body size. The relative benefit both has been debated with the emerging biological novel size descriptors. We used radiomic biomarkers age-related changes in composition to construct new indices as covariates function. A retrospective cohort hospitalized patients plasma concentrations aminoglycosides computed tomography images were evaluated. Aminoglycoside clearance served a surrogate. population pharmacokinetic model was constructed determine whether improved aminoglycoside compared chronological age. final dataset included 156 (51.92% female) median (minimum-maximum) weight 58 [21, 93] years 81 [43.8, 139.3] Kg. 1-compartment linear elimination, incorporating index, serum creatinine, drug type best fits concentration-time data. dorsal muscle group area, bone mineral density, visceral fat subcutaneous density. offered modest improvement over model. This work offers proof-of-concept, highlighting potential for more precise methods aging-related aid personalized pharmacotherapy.

Language: Английский

Citations

0
Effect of age on safety and efficacy of novel cancer drugs investigated in early-phase clinical trials DOI
Eleonora Nicolò, Sara Gandini,

Federica Giugliano

et al.

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 207, P. 114181 - 114181

Published: June 17, 2024

Language: Английский

Citations

2