Nonlinear relationship between phenotypic age acceleration and testosterone deficiency in the US population: A cross-sectional NHANES study DOI Creative Commons
Yiwen Zhou, Yuxi Cai,

Qian Zheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Objective This study aims to assess the relationship between Phenotypic age acceleration (PhenoAgeAccel) and testosterone deficiency (TD) in US male, using National Health Nutrition Examination Survey (NHANES) data from 2015 2016. Methods explored PhenoAgeAccel TD by analyzing a sample reflecting male population of United States (n = 1,402; NHANES 2015–2016). (PA) is calculated nine blood-based biomarkers. was extracting residuals regressing phenotypic on chronological (CA). defined as serum levels below 300 ng/dL, accordance with criteria set forth AUA. research used multivariable logistic models examine connection TD. Additionally, it included subgroup interaction analyses variations among different groups. Smoothed curve fitting generalized additive modelling (GAM) were also employed analyze further. Results The 1,402 subjects, 293 diagnosed 1,109 without. weighted multivariate regression model indicated an 8% higher probability for each unit increase (OR: 1.08, 95% CI: 1.05–1.11) after accounting all covariates. Subgroup analysis outcomes uniform across various categories, demonstrating significant positive Interaction tests showed that link remained consistent P-values exceeding 0.05. Also, non-linear discovered, progressive risk elevated PhenoAgeAccel, exhibiting J-shaped (inflection point: -9.26, p < 0.05). Conclusions Our suggests may be correlated heightened likelihood developing Consequently, could potentially serve valuable biomarker early identification individuals at TD, implications clinical management public health nutrition strategies.

Language: Английский

Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study DOI Creative Commons
Simon Nusinovici, Tyler Hyungtaek Rim, Hengtong Li

et al.

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: unknown, P. 100593 - 100593

Published: Sept. 1, 2024

Language: Английский

Citations

10
Association between surgeon procedure volume and reoperation rates for penile prosthesis implantation DOI Creative Commons
Juan J. Andino,

Navid Leelani,

Ryoko Sato

et al.

The Journal of Sexual Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1
Better Life’s Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007–2010 data DOI Creative Commons
Dongzhe Wu,

Chaoyi Qu,

Peng Huang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

Objective To investigate the relationship between Life’s Essential 8 (LE8) and Phenotypic Age Acceleration (PhenoAgeAccel) in United States adults to explore impact of LE8 on phenotypic biological aging, thereby providing references for public health policies education. Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) conducted 2007 2010, this cross-sectional study analyzed 7,339 aged 20 above. Comprehensive assessments LE8, PhenoAgeAccel, research covariates were achieved through integration Demographics Data, Dietary Laboratory Questionnaire Data derived NHANES. Weighted generalized linear regression models restricted cubic spline plots employed analyze non-linear associations along with gender subgroup analysis interaction effect testing. Results (1) Dividing 2007–2010 NHANES cohort into quartiles based unveiled significant disparities age, gender, race, body mass index, education level, marital status, poverty-income ratio, smoking drinking statuses, diabetes, hypertension, hyperlipidemia, various markers ( p &lt; 0.05). Mean cell volume demonstrated no intergroup differences &gt; (2) The weighted revealed a more pronounced negative correlation higher (Q2, Q3, Q4) PhenoAgeAccel compared lowest quartile both crude fully adjusted This trend was statistically 0.001) full adjustment model. Gender within exhibited male female participants, tests demonstrating results 0.001 males = females). (3) Restricted (RCS) elucidated trends overall subgroups (4) Interaction denoted effects studied stratified variables such as status However, index diabetes manifested 0.05), suggesting that influence might vary depending an individual’s BMI status. Conclusion study, 2007–2010, has emphasizing importance maintaining healthy lifestyle slowing down aging process. Despite limitations posed by study’s design geographical constraints, these findings provide scientific basis development focused practices. Future should further causal mechanisms underlying consider cross-cultural comparisons enhance our understanding aging.

Language: Английский

Citations

4
Prevalence and Sociodemographic Correlates of Chronic Pain Among a Nationally Representative Sample of Older Adults in the United States DOI
Lisa R. LaRowe,

Christine Miaskowski,

Andrea Mayfield

et al.

Journal of Pain, Journal Year: 2024, Volume and Issue: 25(10), P. 104614 - 104614

Published: June 25, 2024

Language: Английский

Citations

4
The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS DOI Creative Commons

Weiyi Shi,

Zihong Cai,

Ren Xiao-xu

et al.

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(3), P. 100488 - 100488

Published: Jan. 15, 2025

This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged older adults in China, as well assess relationship SUA trajectories risk of aging. We utilized data from China Health Retirement Longitudinal Study (CHARLS), selecting participants who completed follow-ups 2011 2015. Biological age was estimated using Klemera-Doubal method, determined by calculating difference an individual's biological their chronological age. Logistic regression models were employed analyze baseline levels, trajectories, aging, adjusting for potential confounding factors. A total 3,520 (average 59.00 years) included. The results indicated a significant linear positive correlation levels Compared group with lowest those highest had markedly increased (OR = 1.5, 95% CI: 1.23-1.83, P < 0.001). Further longitudinal analysis suggested that maintaining low level associated reduction indicates elevated constitute factor adults. Maintaining at low-level help slow down These findings highlight importance monitoring this demographic, providing scientific basis developing interventions delay

Language: Английский

Citations

0
Exploring new markers for biological aging from bioimpedance analysis and cognitive functions in older adults DOI Creative Commons

Dieu Ni Thi Doan,

Boncho Ku,

Kahye Kim

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Aging is a complex process that affects human health and lifespan. While chronological age (CA) significant risk factor for many diseases, it does not fully capture biological changes influence span. This study explores cognitive measures using the Seoul Neuropsychological Screening Battery body composition profiles as potential (BA) markers in older population. Multiple linear regression, principal component analysis (PCA), Klemera–Doubal (KDM) methods were used to construct sex-specific BA formulas from 296 healthy individuals (160 women, 136 men, mean age: 70.3 years). The applied new cohort of 708 diseased people (376 332 73.5 years) generate BAs each sex. Subsequently, we compared classification power CA, BAs, selected variables when differentiating group comorbidity cohort, with sex stratification. As result, found PCA KDM significantly higher than CA but comparable group. yielded accuracies alone. Notably, frontal executive domain score reactance emerged two promising aging. These findings suggest assessments offer more accurate reflection A wider range needed generalize these findings.

Language: Английский

Citations

0
Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults DOI Creative Commons

Lauren Opsasnick,

Wei Zhao, Lauren Schmitz

et al.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: 45, P. 100994 - 100994

Published: April 13, 2025

Psychosocial factors, including cumulative psychosocial stress and loneliness, have been linked to epigenetic aging in older adults. Further, depressive symptoms established relationships with both factors aging. However, it is not known whether mediate the association between aging.We conducted linear regression models examine associations stress, five age acceleration (AA) measures estimated by DNA methylation a multi-racial/ethnic sample of 2681 adults from Health Retirement Study (mean age: 70.4 years). For all identified associations, we tested for effect modification sex educational attainment performed mediation analysis characterize role on these associations.Psychosocial were each associated at least one measure AA (FDR q < 0.05). observed interactions DunedinPACE, as well loneliness GrimAA, PhenoAA, females individuals without college degree appearing more sensitive effects Depressive mediated 24 % 35 HannumAA, 40 37 GrimAA respectively. this study may help elucidate relationship aging, which critical understanding biological mechanisms through contribute age-related disease.

Language: Английский

Citations

0
Shaping the future of geriatric chronic pain care: a research agenda for progress DOI
Lisa R. LaRowe, Tony V Pham, Claire Szapary

et al.

Pain Management, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 17, 2025

Chronic pain is highly prevalent among older adults and its burden will become increasingly significant as our population ages. Yet, chronic often undertreated in this vulnerable due to various barriers health care delivery. To improve geriatric management, we assert that require a dedicated research agenda designed inform the development, testing, implementation of treatments account for unique vulnerabilities healthcare needs population. Specifically, propose following four areas immediate attention better serve with pain: (1) equity, (2) substance use, (3) dyadic interventions, (4) digital health. Our proposed aims create more robust comprehensive body evidence ultimately transform advance management.

Language: Английский

Citations

0
A comparison between radiomic biological age and chronological age in estimating kidney function DOI Creative Commons
Radin Alikhani, Steven R. Horbal, Manjunath P. Pai

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

Abstract Accurate kidney function estimation hinges on essential markers of age and body size. The relative benefit both has been debated with the emerging biological novel size descriptors. We used radiomic biomarkers age-related changes in composition to construct new indices as covariates function. A retrospective cohort hospitalized patients plasma concentrations aminoglycosides computed tomography images were evaluated. Aminoglycoside clearance served a surrogate. population pharmacokinetic model was constructed determine whether improved aminoglycoside compared chronological age. final dataset included 156 (51.92% female) median (minimum-maximum) weight 58 [21, 93] years 81 [43.8, 139.3] Kg. 1-compartment linear elimination, incorporating index, serum creatinine, drug type best fits concentration-time data. dorsal muscle group area, bone mineral density, visceral fat subcutaneous density. offered modest improvement over model. This work offers proof-of-concept, highlighting potential for more precise methods aging-related aid personalized pharmacotherapy.

Language: Английский

Citations

0
Serum sodium within the normal range and its U-shaped relationship with biological aging in U.S. adults DOI Creative Commons

Xianxiang Tong,

Fei Wang, Mengxue Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 8, 2025

Background This cross-sectional study evaluated the correlation between serum sodium levels (135–145 mmol/L) and biological aging in U.S. adults. Biological age, derived from multi-system biomarkers, provides a more accurate assessment of than chronological age. Hydration balance, reflected by sodium, may modulate age-related diseases mortality, but its link to remains underexplored. Methods Using NHANES data (1999–2018), we focused on normonatremic adults (≥20 years). The final cohort included 18,301 participants. age was estimated using Klemera Doubal method, ∆age (biological age—chronological age) calculated. Associations were assessed multivariate regression, generalized additive models, threshold analysis. Subgroup analyses conducted for variations across different populations. Results Nonlinear analysis revealed U-shaped relationship lowest occurred at 139.3 mmol/L: each 1 mmol/L increase below this associated with reduction 0.10 years (95% CI: −0.15, −0.05), whereas values above it showed 0.08-year 0.04, 0.13). For ∆age, negative association observed 141.2 mmol/L, linked 0.07-year decrease −0.10, −0.04). significant interactions diabetic smoking Conclusion Maintaining within an optimal range (138–142 help delay aging. management serve as modifiable factor healthy aging, particularly high-risk groups such individuals diabetes or tobacco use.

Language: Английский

Citations

0