Metabolic dysfunction associated steatotic liver and kidney stones: what is going on?

Current Opinion in Nephrology & Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Metabolic dysfunction associated steatotic liver disease (MASLD) is increasing throughout the world, affecting nearly one in three individuals. Kidney stone disease, which also increasing, with MASLD. Common risk factors for both, including obesity, diabetes, dyslipidemia, hypertension, and metabolic syndrome, are likely drivers of this association. We present here a review associations possible interconnections between these two common processes. Epidemiological studies discordant regarding impact sex on association MASLD incident risk. The nature kidney stones rarely taken into account.A favorable milieu uric acid formation may be created by lower urine pH resulting from defective ammonium production insulin resistance, MASLD.Endogenous oxalate synthesis, major factor calcium stones, increased via decline activity enzymes involved detoxification glyoxylate, immediate precursor oxalate. driving remain to elucidated. Potential mechanisms identified underlying include an increase both stones.

Language: Английский

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A simple, reliable and easily generalizable cell-based assay for screening potential drugs that inhibit lipid accumulation

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 8, P. 100213 - 100213

Published: Dec. 26, 2024

Language: Английский

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Metabolic dysfunction-associated steatotic liver disease and urinary system cancers: Mere coincidence or reason for concern?

Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 156066 - 156066

Published: Nov. 1, 2024

Language: Английский

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