Cutaneous Adverse Reactions of Anticancer Agents

Dermatologic Clinics, Journal Year: 2019, Volume and Issue: 37(4), P. 555 - 568

Published: July 27, 2019

Language: Английский

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Thermoresponsive Chitosan-Grafted-Poly(N-vinylcaprolactam) Microgels via Ionotropic Gelation for Oncological Applications

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(10), P. 1654 - 1654

Published: Oct. 11, 2021

Microgels can be considered soft, porous and deformable particles with an internal gel structure swollen by a solvent average size between 100 1000 nm. Due to their biocompatibility, colloidal stability, unique dynamicity the permeability of architecture, they are emerging as important candidates for drug delivery systems, sensing biocatalysis. In clinical applications, research on responsive microgels is aimed at development "smart" systems that undergo critical change in conformation reaction environmental conditions (temperature, magnetic fields, pH, concentration gradient). Recent achievements biodegradable polymer fabrication have resulted new appealing strategies, including combination synthetic natural-origin polymers inorganic nanoparticles, well possibility controlling release remotely. this review, we provide literature review use dual multi-responsive chitosan-grafted-poly-(

Language: Английский

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Capsicum annuum Oleoresin Nanoemulgel - Design Characterization and In vitro Investigation of Anticancer and Antimicrobial Activities

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(2), P. 151 - 160

Published: Jan. 1, 2024

Background:: The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected provide an important source for the natural products industry aiming develop novel treatments skin conditions. In this work, Capsicum annuum oleoresin nanoemulgel formulations have been prepared investigated antibacterial anticancer Methodology:: Several C. were by incorporating a Carbopol 940 gel in self-nanoemulsifying nanoemulsion consisting annuum, tween 80, span 80. systems characterized particle size, polydispersity index (PDI), zeta potential, rheology. vitro antimicrobial cytotoxic activities optimum formulation evaluated. Results:: selected composed 40% tween, 10% oleoresin. This produced stable with narrow PDI value 0.179 ± 0.08 droplet size 104.0 2.6 nm. Results studies indicated high potency against methicillin-resistant Staphylococcus aureus (MRSA) (zone inhibition 29 1.9 mm), E. coli (33 0.9 K. pneumonia (30 1.4 albicans (21 1.5 compared reference antibiotic, ampicillin (18 mm pneumonia), antifungal agent, fluconazole (12 0.1 albicans). Furthermore, cytotoxicity results, expressed IC50 values, revealed that its had best effects HepG2 cell line (IC50 79.43 μg/mL nanoemulgel) MCF7 57.54 μg/mL), most potent effect was found 3T3 45.7 μg/m- L). On other side, system did not substantially exhibit activity By-61 Hela. Conclusion:: can be considered valuable sources discovery new antibacterial, antifungal, compounds pharmaceutical industry, especially due various cancer lines well bacterial fungal strains.

Language: Английский

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Systematic review and network meta-analysis of drug combinations suggested by machine learning on genes and proteins, with the aim of improving the effectiveness of Ipilimumab in treating Melanoma

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 14, 2023

ABSTRACT Background (Importance) One of the most dangerous kinds skin cancer, Melanoma, develops in cells (melanocytes) that make melanin, pigment responsible for giving your its color. As well as developing everywhere on body, including eyes, Melanoma can sporadic occur internally, such nose or throat. It is unknown what causes all melanomas, although exposure to ultraviolet (UV) radiation from sun, tanning salons, and lamps increases risk getting them. a result, chance obtaining Melanoma. Limiting UV help reduce (Objective) Due nature this disease severe impact human genes, use safe effective drug combinations treatment very important. Proposed should be administered with greatest positive effect genes involved. Therefore, it important suggest an combination significantly affect Method (Data sources) This systematic review network meta-analysis searched various databases, Science Direct, Embase, Scopus, PubMed, Web (ISI), Google Scholar, without lower time limit up until July 2022, articles focused managing The study utilized explore effectiveness proposed medication proteins may act potential targets improving treatment. Results results show p-value between was 1.12E-08. while only one has maximum value 0.0149. combination’s treating increased 74 times. A investigated validity combinations, meta-analysis, prescription information. Conclusion findings reduces could potentially targeted slow progression disease, ultimately management. selecting appropriate critical enhancing community health reducing per capita expenses. Highlights aggressive begins producing melanin. Therapy must pharmacological are both effective. Any delivered way will have possible beneficial at play. In research, melanoma illness investigated. suggested identified therapy. indicates approach improve management

Language: Английский

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Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after programmed cell death 1 inhibition with nivolumab

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2017, Volume and Issue: 32(2)

Published: Aug. 4, 2017

Language: Английский

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