Биохимия,
Journal Year:
2023,
Volume and Issue:
88(7), P. 1069 - 1084
Published: Dec. 15, 2023
The
mechanisms
of
carcinogenesis
are
extremely
complex.
Many
players
determine
the
scenario
malignant
cell
transformation,
tumor
growth
and
metastasis.
In
recent
decades,
more
attention
has
been
paid
to
role
symbiotic
human
microbiota
in
regulation
metabolism
functioning
immune
system
host
organism.
Such
a
symbiosis
macroorganism
its
microorganisms
was
combined
into
concept
holoorganism.
process
coevolution
participants
holoorganism,
ways
their
interaction
were
formed,
metabolites
acquired
special
-
signaling
molecules
main
regulators
molecular
interactions
Being
involved
pathways
host,
bacterial
turned
out
be
obligatory
both
physiological
pathological
processes,
including
growth.
At
same
time,
effects
often
have
multidirectional
character,
manifested
impact
on
functions
cells
metabolic
activity
composition
microbiome.
This
review
discusses
some
microbiotic
induction
prevention
transformation
organism,
as
well
influence
effectiveness
anticancer
therapy.
We
tried
draw
reader’s
components
orchestra
microbial
initiation
progression
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(36), P. 4025 - 4030
Published: Sept. 20, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
gastrointestinal
inflammatory
disease.
With
the
emergence
of
biologics
and
other
therapeutic
methods,
two
or
one
biologic
combined
with
novel
small-molecule
drug
has
been
proposed
in
recent
years
to
treat
IBD.
Although
treatment
strategies
for
IBD
are
being
optimized,
their
efficacy
risks
still
warrant
further
consideration.
This
editorial
explores
current
associated
dual-targeted
great
potential
that
fecal
microbiota
transplantation
(FMT)
may
have
use
combination
therapy
We
focused
on
addressing
refractory
biologically
resistant
based
currently
available
by
incorporating
FMT
as
part
this
treatment.
In
new
regimen,
represents
promising
therapy.
This
review
systematically
examines
the
multifaceted
relationship
between
tumor
microenvironment,
stromal
interactions,
and
colorectal
cancer
(CRC)
progression
metastasis.
The
analysis
begins
by
assessing
gut
microbiome's
influence
on
CRC
development,
emphasizing
its
association
with
gut-associated
lymphoid
tissue
(GALT).
role
of
Wnt
signaling
pathway
in
stroma
is
scrutinized,
elucidating
impact
disease
progression.
Tumor
budding,
effect
stroma,
implications
for
patient
prognosis
are
investigated.
also
identifies
conserved
oncogenic
signatures
(COS)
within
explores
their
potential
as
therapeutic
targets.
Lastly,
seed
soil
hypothesis
employed
to
contextualize
metastasis,
accentuating
significance
both
cells
surrounding
metastatic
propensity.
In
summary,
this
highlights
intricate
interdependence
providing
valuable
insights
into
prospective
approaches
targeting
tumor-stroma
interactions.
Gastrointestinal Tract,
Journal Year:
2023,
Volume and Issue:
1
Published: Sept. 22, 2023
Colorectal
cancer
(CRC)
is
the
third
most
prevalent
globally
and
second
deadliest
for
both
men
women.
To
change
this
situation,
novel
therapeutic
approaches
have
been
developed,
with
immunotherapy
being
one
of
promising.
This
technique
employs
patient's
immune
system
to
identify
eradicate
cells.
The
intestinal
microbiota
composed
various
microorganisms,
such
as
bacteria,
viruses,
protozoa,
fungi.
microbiome
has
vital
functions
human
being,
participation
in
digestion,
vitamin
production,
protection
against
aggressive
pathogens,
modulation
system.
Dysregulation
homeostasis
can
generate
injuries
affected
person,
which
carcinogenesis.
From
this,
assumed
a
relevant
role
process
by
acting
through
its
blocking
some
checkpoints
and,
consequently,
resulting
greater
efficiency
cytotoxic
activity
T
Therefore,
review
aims
comprehend
mechanism
directly
impacts
development
CRC
especially,
mechanisms
generates
better
prognosis
patients.
Биохимия,
Journal Year:
2023,
Volume and Issue:
88(7), P. 1069 - 1084
Published: Dec. 15, 2023
The
mechanisms
of
carcinogenesis
are
extremely
complex.
Many
players
determine
the
scenario
malignant
cell
transformation,
tumor
growth
and
metastasis.
In
recent
decades,
more
attention
has
been
paid
to
role
symbiotic
human
microbiota
in
regulation
metabolism
functioning
immune
system
host
organism.
Such
a
symbiosis
macroorganism
its
microorganisms
was
combined
into
concept
holoorganism.
process
coevolution
participants
holoorganism,
ways
their
interaction
were
formed,
metabolites
acquired
special
-
signaling
molecules
main
regulators
molecular
interactions
Being
involved
pathways
host,
bacterial
turned
out
be
obligatory
both
physiological
pathological
processes,
including
growth.
At
same
time,
effects
often
have
multidirectional
character,
manifested
impact
on
functions
cells
metabolic
activity
composition
microbiome.
This
review
discusses
some
microbiotic
induction
prevention
transformation
organism,
as
well
influence
effectiveness
anticancer
therapy.
We
tried
draw
reader’s
components
orchestra
microbial
initiation
progression
