Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117662 - 117662

Published: Jan. 1, 2025

Rhinitis is one of the most common respiratory diseases, influenced by various environmental factors such as green space, air pollution and indoor microbiomes. However, their interactions combined effects have not been reported. We recruited 1121 preschool children from day care centers in a northern city China. Health demographic data were collected through questionnaires answered children's parents. Surrounding space was assessed Normalized Difference Vegetation Index (NDVI), Enhanced (EVI) land cover grassland proportion within 1500/3000 m. Ambient estimated using inverse distance weighted (IDW), microbiome classroom vacuum dust profiled bacterial 16S rRNA fungal ITS amplicon sequencing. Mixed-effect logistic regression revealed natural grassland, leaf-off total negatively associated with current rhinitis. Stratified analysis indicated that greater exposure reduced rhinitis at high levels pollution. Additionally, also protects against tobacco smoke home. Indoor showed Haemophilus Dolosigranulum enriched low-rhinitis centers, while Amaricoccus, Blautia Mycosphaerella high-rhinitis centers. Mediation did significant mediating on relationship between This first study to reveal rhinitis, providing new insights into how collectively influence health children.

Language: Английский

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Associations of Parental Air Pollution and Greenness Exposures with Offspring Asthma Outcomes: The Life-GAP Project

Published: Jan. 1, 2025

BackgroundAir pollution and greenness have been linked to personal respiratory health, but potential intergenerational effects are poorly understood. We investigated whether pre-conception parental residential exposure air at age 20-44 years is associated with asthma outcomes in offspring.MethodsWe analysed data on 3684 RHINESSA study participants born after the year 1990 (mean 19, SD 4), offspring of 2689 RHINE participants. Modeled annual concentrations particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), elemental carbon (EC), ozone (O3), as well (Normalized Difference Vegetation Index, NDVI) were assigned addresses 1990, corresponding 1 18 prior birth (mean: 6 years, SD: 5). analyzed associations using generalized structural equation modelling (GSEM), cluster-robust standard errors allowing for intra-family correlation, while adjusting confounders centre fixed-effects.ResultsAmong participants, 18% reported lifetime asthma, 9% active 8% medication, 5% attacks, 37% any symptom. An interquartile range (IQR) increase NDVI was less (OR= 0.79, 95%CI: 0.64, 0.98 per 0.3 units). Similar observed medication use. Associations inconclusive.ConclusionParental green spaces before conception consistently a lower risk offspring. Increasing evidence suggests that urban planning policies prioritizing could serve key public health intervention future cities.

Language: Английский

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Associations of parental air pollution and greenness exposures with offspring asthma outcomes

Environmental Research, Journal Year: 2025, Volume and Issue: 274, P. 121328 - 121328

Published: March 6, 2025

Air pollution and greenness impact respiratory health, but intergenerational effects remain unclear.We investigated whether pre-conception parental residential exposure to air at age 20-44 years is associated with offspring asthma outcomes in the Lifespan inter-generational of exposures (Life-GAP) project. We analyzed data on 3684 RHINESSA study participants born after year 1990 (mean 19, standard deviation 4), 2689 RHINE participants. Modelled annual concentrations particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), elemental carbon (EC), ozone (O3), (Normalized Difference Vegetation Index, NDVI) were assigned addresses 1990, corresponding 1-18 prior birth (mean: 6 years, SD: 5). associations using generalized structural equation modelling (GSEM), cluster-robust errors allowing for intra-family correlation, while adjusting potential confounders. Among participants, 18% reported lifetime asthma, 9% active 8% medication, 5% attacks, 37% any symptom. An interquartile range (IQR) increase NDVI was less (OR = 0.79, 95%CI: 0.64, 0.98 per 0.3 units). Similar observed medication use. Associations inconclusive. Parental green spaces before conception lower risk offspring. Urban planning policies prioritizing may be a key public health intervention future cities.

Language: Английский

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The impact of atmospheric pollutants on the physical health of college students——based on physical examination data of college students from a certain university in Xi’an, Shaanxi Province, China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 24, 2025

Background Air pollution, particularly particulate matter (PM 2.5 /PM 10 ), poses a significant environmental health threat in urban China. While previous research has primarily focused on older adult populations, the impact of air pollution college students—an important yet underexplored demographic—remains largely unclear. This study investigates effects pollutants physical fitness and lung function among students at university Xi’an, city known for its persistent quality challenges. Methods We used longitudinal examination data (2019–2022) from 21,580 to perform empirical correlation regression kernel density estimation. Trends vital capacity scores were analyzed alongside indicators (AQI, PM , CO). A mixed cross-sectional econometric model controlled individual characteristics such as height (mean = 170.66 cm, SD 8.37), weight 64.94 kg, 13.40), gender 0.313, 0.464), factors temperature, wind speed, green coverage 41.22, 1.45). Physical exhibited high variability (SD 9.62, range 10.2–109). Results was significantly associated with reduction scores. 1-unit increase AQI linked 0.1094-unit decline ( p < 0.01). The negative effect further amplified by β −0.2643) CO (β −11.5438). Senior students, especially females, showed increased vulnerability adverse pollution. mirrored those fitness, outliers suggesting susceptibility. Notably, reduced found mediate 22% 0.05). Conclusion highlights disproportionate emphasizing need policies that focus reducing emissions, expanding campus greenery, promoting education. Future should incorporate fixed broaden include wider regions universities.

Language: Английский

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Respiratory Health Impacts from Natural Disasters and Other Extreme Weather Events: The Role of Environmental Stressors on Asthma and Allergies

Current Allergy and Asthma Reports, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 21, 2025

Language: Английский

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Epidemiology of Respiratory Allergies and Asthma

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 66

Published: Jan. 1, 2024

Language: Английский

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The potential of orally exposed risk factors and constituents aggravating food allergy: Possible mechanism and target cells

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(5)

Published: Sept. 1, 2024

Abstract Food allergy is a significant concern for the health of humans worldwide. In addition to dietary exposure food allergens, genetic and environmental factors also play an important role in development allergy. However, only tip iceberg risk has been identified. The importance caused by orally exposed constituents, including veterinary drugs, pesticides, processed foods/derivatives, nanoparticles, microplastics, pathogens, toxins, additives, intake salt/sugar/total fat, vitamin D, therapeutic are highlighted discussed this review. Moreover, epithelial barrier hypothesis, which closely associated with occurrence allergy, introduced. Additionally, several constituents that have reported disrupt elucidated. Finally, possible mechanisms key immune cells aggravating overviewed. Further work should be conducted define specific mechanism these driving will central targeted therapy

Language: Английский

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Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model

Allergy, Journal Year: 2023, Volume and Issue: 79(2), P. 432 - 444

Published: Oct. 7, 2023

Abstract Background Environmental exposure to peanut through non‐oral routes is a risk factor for allergy. Early‐life air pollutants, including particulate matter (PM), associated with sensitization foods unknown mechanisms. We investigated whether PM promotes environmental and the development of allergy in mouse model. Methods C57BL/6J mice were co‐exposed either urban (UPM) or diesel exhaust particles (DEP) via airways assessed anaphylaxis following challenge. Peanut‐specific CD4 + T helper (Th) cell responses characterized by flow cytometry Th cytokine production. Mice lacking select innate immune signaling genes used study mechanisms PM‐induced Results Airway co‐exposure UPM‐ DEP‐induced systemic Exposure UPM DEP triggered activation migration lung dendritic cells draining lymph nodes induction peanut‐specific cells. distinct responses, but both stimulated expansion follicular (Tfh) essential development. MyD88 was critical allergy, whereas TLR4 dispensable. Tfh‐cell differentiation depended on IL‐1 not IL‐33 signaling, neither alone necessary UPM‐mediated sensitization. Conclusion induces Tfh mice.

Language: Английский

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Allergen immunotherapy: progress and future outlook

Expert Review of Clinical Immunology, Journal Year: 2023, Volume and Issue: 19(7), P. 745 - 769

Published: May 1, 2023

Allergy, the immunological hypersensitivity to innocuous environmental compounds, is a global health problem. The disease triggers, allergens, are mostly proteins contained in various natural sources such as plant pollen, animal dander, dust mites, foods, fungi, and insect venoms. Allergies can manifest with wide range of symptoms organs be anything from just tedious life-threatening. A majority all allergy patients self-treated symptom-relieving medicines, while allergen immunotherapy (AIT) only causative treatment option.This review will aim give an overview state-of-the-art management, including use new biologics application biomarkers, special emphasis discussion on current research trends field AIT.Conventional AIT has proven effective, but years-long compromises patient compliance. Moreover, typically not offered for food allergies. Hence, there need new, safe methods. Novel routes administration (e.g. oral intralymphatic), hypoallergenic products, more effective adjuvants hold great promise. Most recently, development allergen-specific monoclonal antibodies passive may also allow currently treated or treatable.

Language: Английский

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Interpretable machine learning for allergic rhinitis prediction among preschool children in Urumqi, China

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 27, 2024

Language: Английский

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