Tolerogenic nanovaccines for the treatment of type I allergic diseases

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 664 - 685

Published: Feb. 17, 2025

Language: Английский

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The Epithelial Barrier Hypothesis in Food Allergies: The State of the Art

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1014 - 1014

Published: March 14, 2025

Recently, the “epithelial barrier hypothesis” has been proposed as a key factor in development of allergic diseases, such food allergies. Harmful environmental factors can damage epithelial barriers, with detrimental effects on host immune response and local microbial equilibrium, resulting chronic mucosal inflammation that perpetuates dysfunction barrier. The increased permeability allows allergens to access submucosae, leading an imbalance between type 1 T-helper (Th1) 2 (Th2) inflammation, predominant Th2 is allergy development. In this article state art, we review scientific evidence hypothesis”, focus We describe how loss integrity skin intestinal modifications gut microbiota composition contribute inflammatory changes immunological unbalance lead

Language: Английский

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IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

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Allergic rhinitis in children is associated with high serum levels of zonulin

International Journal of Pediatric Otorhinolaryngology, Journal Year: 2025, Volume and Issue: unknown, P. 112350 - 112350

Published: April 1, 2025

Language: Английский

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The Association Between Helicobacter pylori Infection and Eosinophilic Esophagitis: Systematic Review and Meta‐Analysis

Helicobacter, Journal Year: 2025, Volume and Issue: 30(2)

Published: March 1, 2025

ABSTRACT Background Exposure to Helicobacter pylori ( H. ) has been associated with reduced odds of eosinophilic esophagitis (EoE). Aims To conduct a systematic review and meta‐analysis epidemiological studies in order quantify the association between infection EoE, assess certainty evidence linking both conditions. Methods A comprehensive literature search was conducted MEDLINE/PUBMED, EMBASE, SCOPUS databases (up September 2024) identify observational that assessed objectively measured EoE. The risk study bias structurally using ROBINS‐E tool. Data were pooled random‐effects meta‐analysis. GRADE approach. Results Sixteen comprising 30,650 patients 291,908 controls included. significant reduction EoE (pooled ratio [OR] 0.56; 95% CI, 0.46–0.70; I 2 50%) [low‐certainty evidence]. protective effect stronger case–control (OR 0.49; 0.35–0.69) than cohort 0.76; 0.58–0.98) statistically retrospective 0.57; 0.45–0.72) high or very 0.52; 0.42–0.64), but not prospective 0.27–1.18) those moderate low (OR, 0.91; 0.69–1.21). Conclusions is mainly supported by bias. Further well‐designed are needed. Trial Registration PROSPERO number: CRD42024586653

Language: Английский

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Mathematical Modeling of Gas-phase Mass Transfer in Hydrous Materials for a Total Heat Exchange Ventilator

Building and Environment, Journal Year: 2024, Volume and Issue: 267, P. 112291 - 112291

Published: Nov. 9, 2024

Language: Английский

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Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

Allergy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Since the 1960s, more than 350,000 new chemicals have been introduced into lives of humans and domestic animals. Many them become part modern life some are affecting nature as pollutants. Yet, our comprehension their potential health risks for both animals remains partial. The “epithelial barrier theory” suggests that genetic predisposition exposure to diverse factors damaging epithelial barriers contribute emergence allergic autoimmune conditions. Impaired barriers, microbial dysbiosis, tissue inflammation observed in a high number mucosal inflammatory, neuropsychiatric diseases, many which showed increased prevalence last decades. Pets, especially cats dogs, share living spaces with exposed household cleaners, personal care products, air pollutants, microplastics. utilisation cosmetic products food additives pets is on rise, unfortunately, accompanied by less rigorous safety regulations those governing human products. In this review, we explore implications disruptions well‐being companion animals, drawing comparisons humans, endeavour elucidate spectrum diseases afflict them. addition, future research areas interconnectedness human, animal, environmental highlighted line “One Health” concept.

Language: Английский

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Bacteria and Allergic Diseases

Published: Aug. 19, 2024

Microorganisms have colonized all barrier tissues and are present on the skin mucous membranes since birth. Bacteria many ways of influencing host organism: activation innate immunity receptors by PAMPs; synthesis various chemical compounds, such as vitamins, short-chain fatty acids, bacteriocins, toxins. Bacteria, using extracellular vesicles, can introduce high-molecular proteins nucleic into cell, regulating metabolic pathways cells. Epithelial cells immune recognize bacterial bioregulators and, depending microenvironment context, determine direction intensity response. A large number factors influence maintenance symbiotic microflora, diversity which protects against pathogen colonization. Reduced is associated with dominance allergic diseases skin, gastrointestinal tract, upper lower respiratory seen in atopic dermatitis, rhinitis, chronic rhinosinusitis, food allergies, asthma. Understanding multifactorial microflora maintaining health disease determines effectiveness therapy prevention, changes our preferences lifestyle to maintain active longevity.

Language: Английский

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Bacteria and Allergic Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10298 - 10298

Published: Sept. 25, 2024

Microorganisms colonize all barrier tissues and are present on the skin mucous membranes from birth. Bacteria have many ways of influencing host organism, including activation innate immunity receptors by pathogen-associated molecular patterns synthesis various chemical compounds, such as vitamins, short-chain fatty acids, bacteriocins, toxins. Bacteria, using extracellular vesicles, can also introduce high-molecular proteins nucleic into cell, regulating metabolic pathways cells. Epithelial cells immune recognize bacterial bioregulators and, depending microenvironment context, determine direction intensity response. A large number factors influence maintenance symbiotic microflora, diversity which protects hosts against pathogen colonization. Reduced is associated with dominance allergic diseases skin, gastrointestinal tract, upper lower respiratory seen in atopic dermatitis, rhinitis, chronic rhinosinusitis, food allergies, asthma. Understanding multifactorial microflora maintaining health disease determines effectiveness therapy prevention changes our preferences lifestyle to maintain active longevity.

Language: Английский

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The potential of including the microbiome as biomarker in population-based health studies: methods and benefits

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 23, 2024

The key role of our microbiome in influencing health status, and its relationship with environment lifestyle or behaviors, have been shown the last decades. Therefore, human has potential to act as a biomarker indicator exposure risks general population, if information on can be collected population-based surveys cohorts. It could then associated epidemiological participant data such demographic, clinical profiles. However, knowledge, sampling not yet included biological evidence large studies representative population. In this mini-review, we first highlight some practical considerations for analysis that need considered context population study. We present examples topics where benefit public health, how developed future. doing so, aim benefits having available at level combined from surveys, hence microbiological used future assess health. also stress challenges remain overcome allow use order improve proactive policies.

Language: Английский

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