NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway DOI Creative Commons

Nuerbiyemu Maimaitiaili,

Yanxi Zeng,

Peinan Ju

et al.

Experimental Cell Research, Journal Year: 2023, Volume and Issue: 431(2), P. 113755 - 113755

Published: Aug. 14, 2023

Hypoxia-induced pulmonary hypertension is a subgroup of type 3 (PH) with the recommended treatment limited to oxygen therapy and lacks potential therapeutic targets. To investigate role NLRC3 in hypoxia-induced PH its mechanism, we first collected lung tissues high-altitude (HAPH) patients. Immunohistochemistry immunofluorescence showed that was downregulated mainly co-localized smooth muscle cells vessels HAPH Besides, found also expressed endothelial patients for time. Then, wild (WT) knockout (NLRC3−/−) mice were used construct hypoxia models primary arterial (PASMCs) rats cultured verification. Right heart catheterization echocardiography suggested promoted right ventricular systolic pressure (RVSP) up-regulation, hypertrophy fibrosis mice. This study demonstrated deficiency hypoxia-stimulated PASMCs proliferation, Human Umbilical Vein Endothelial Cells (HUVEC) apoptosis, migration inflammation through IKK/NF-κB p65/HIF-1α pathway vitro vivo, further vascular remodeling progression, which provided new target PH.

Language: Английский

COVID-19 and Long-term Risk of Ischemic Heart Disease in Asthma DOI Open Access
Sungmin Zo, Hyun Lee, Cho Yun Jeong

et al.

Allergy Asthma and Immunology Research, Journal Year: 2025, Volume and Issue: 17(1), P. 135 - 135

Published: Jan. 1, 2025

Despite the importance of comorbid ischemic heart disease (IHD) in prognosis asthma, long-term impact coronavirus 2019 (COVID-19) on IHD adults with asthma remains unclear. This study investigated effects COVID-19 risk individuals particularly regarding severity. Using Korean National Health Insurance Service claims database, we identified who had recovered from between October 8, 2020, and December 31, 2021 (n = 8,011) 1:1 propensity score-matched controls 8,011). The incidence were compared two groups. Overall, during a median follow-up 95 days (interquartile range, 34-213 days; 1-448 days), which includes 14 lag days, cohort did not show higher (hazard ratio [HR], 2.11; 95% confidence interval [CI], 0.99-4.48) to matched controls. However, when severity was considered, severe exhibited (HR, 4.89; CI, 1.86-12.84) than controls; contrast, non-severe showed no significantly increased 1.64; 0.73-3.70). Severe is associated an emphasizing cardiovascular events monitoring improve treatment outcomes era COVID-19.

Language: Английский

Citations

0
Impact of COVID-19 Vaccination on Cardiac Function and Survival in Maintenance Hemodialysis Patients DOI Creative Commons

Xiao Tu,

Tingfei He,

Bing Xu

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 208 - 208

Published: Feb. 20, 2025

Maintenance hemodialysis patients are at increased risk of cardiovascular complications and mortality following COVID-19 infection due to compromised immune function. This study aims evaluate the impact vaccine (CoronaVac) on cardiac function survival in this population. Background/Objectives: We aimed examine whether CoronaVac vaccination affects heart rates maintenance patients. Specifically, we assessed changes ultrasound (echocardiographic) measurements, B-type natriuretic peptide (BNP) levels, outcomes by comparing vaccinated unvaccinated Methods: A retrospective analysis was conducted 531 patients, including 79 who received 452 did not. compared pre- post-infection (echocardiographic parameters) BNP levels between two groups their association with rates. Results: The were younger (60.54 ± 13.51 vs. 65.21 13.76 years, p = 0.006) had shorter dialysis durations (56.04 51.88 73.73 64.79 months, 0.022). rate also significantly lower group (6.33% 14.38%, 0.049). After infection, showed significant declines while demonstrated no deterioration. Older age, coronary artery disease, inflammation abnormalities identified as key factors for mortality. Conclusions: linked better may help reduce severity, strain heart, improve overall prognosis.

Language: Английский

Citations

0
Possible perspectives for cardiovascular events following coronavirus disease 2019 vaccination DOI

Xueyan Gong,

James Cheng‐Chung Wei, Liyun Zhang

et al.

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Journal Article Possible perspectives for cardiovascular events following coronavirus disease 2019 vaccination Get access Xue-Yan Gong, Gong Third Hospital of Shanxi Medical University, Bethune Hospital, Academy Sciences, Tongji No.99 Longcheng Street, Taiyuan, 030032, China https://orcid.org/0009-0000-5985-2441 Search other works by this author on: Oxford Academic PubMed Google Scholar James Cheng-Chung Wei, Wei ChinaInstitute Medicine, Chung Shan No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201, TaiwanDepartment Allergy, Immunology & Rheumatology, University TaiwanGraduate Institute Integrated Taiwan Corresponding author. Email: [email protected] (L.-Y.Z.); (J.C.-C.W.) Li-Yun Zhang European Heart Journal, ehaf112, https://doi.org/10.1093/eurheartj/ehaf112 Published: 07 March 2025

Language: Английский

Citations

0
COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability DOI Creative Commons
Yifan Zhao,

Xiaorong Han,

Cheng Li

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 7, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans can lead to various degrees of tissue and organ damage, which cardiovascular system diseases are one the main manifestations, such as myocarditis, myocardial infarction, arrhythmia, threaten infected population worldwide. These health populations Although prevalence disease 2019 (COVID-19) has slightly improved with virus mutation vaccination, chronic infection, post-infection sequelae, patients still exist, it is relevant study mechanisms linking COVID-19 (CVD). This article introduces pathophysiological mechanism COVID-19-mediated analyzes recent progress interaction between SARS-CoV-2 from roles angiotensin-converting enzyme (ACE2), cellular molecular mechanisms, endothelial dysfunction, insulin resistance, iron homeostasis imbalance, psychosocial factors, respectively. We also discussed differences involved combined neocoronavirus different provided a theoretical basis for better prevention management.

Language: Английский

Citations

10
NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway DOI Creative Commons

Nuerbiyemu Maimaitiaili,

Yanxi Zeng,

Peinan Ju

et al.

Experimental Cell Research, Journal Year: 2023, Volume and Issue: 431(2), P. 113755 - 113755

Published: Aug. 14, 2023

Hypoxia-induced pulmonary hypertension is a subgroup of type 3 (PH) with the recommended treatment limited to oxygen therapy and lacks potential therapeutic targets. To investigate role NLRC3 in hypoxia-induced PH its mechanism, we first collected lung tissues high-altitude (HAPH) patients. Immunohistochemistry immunofluorescence showed that was downregulated mainly co-localized smooth muscle cells vessels HAPH Besides, found also expressed endothelial patients for time. Then, wild (WT) knockout (NLRC3−/−) mice were used construct hypoxia models primary arterial (PASMCs) rats cultured verification. Right heart catheterization echocardiography suggested promoted right ventricular systolic pressure (RVSP) up-regulation, hypertrophy fibrosis mice. This study demonstrated deficiency hypoxia-stimulated PASMCs proliferation, Human Umbilical Vein Endothelial Cells (HUVEC) apoptosis, migration inflammation through IKK/NF-κB p65/HIF-1α pathway vitro vivo, further vascular remodeling progression, which provided new target PH.

Language: Английский

Citations

10