A Synergistic Effect of Remnant Cholesterol and C-Reactive Protein on Predicting the Severity of Coronary Artery Disease DOI Creative Commons
Zhen Zhang, Qiang Chen, Qiping Chen

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11291 - 11303

Published: Dec. 1, 2024

Increased levels of remnant cholesterol (RC) and inflammation are linked to higher risks atherosclerotic cardiovascular disease. Whether a combination C-reactive protein (CRP) RC improves the predictive ability for evaluating severity coronary artery lesions remains unknown. A total 1675 patients with disease were stratified according Synergy Between Percutaneous Coronary Intervention (SYNTAX) score (SYNTAX ≤22 versus SYNTAX >22). Logistic regression restricted cubic spline models used evaluate relationship between RC, CRP lesions. Multivariate logistic was identify predictors mid/high The value combined estimated by ROC curve, continuous net reclassification improvement (NRI) integrated discrimination (IDI). multivariable-adjusted odds ratios (95% CIs) highest lowest quartile 2.143 (1.450-3.166) association maintained significant in subsample patients, regardless traditional risk factors like LDL-C glycemic metabolism status. Moreover, addition baseline model had an incremental effect on (increase C‑statistic from 0.650 0.698; IDI 0.03; NRI 0.306; all P < 0.01). Elevated significantly associated even optimal low-density lipoprotein levels. Adjustment further improved might serve as noninvasive predictor CAD complexity could potentially influence management therapeutic approach.

Language: Английский

The mitochondrial dysfunction, alongside the modifiable burden of traditional risk factors, drives the development of early-onset coronary artery disease DOI Creative Commons
Jonica Campolo, Paola Canale, Gianluca Gazzaniga

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 19, 2025

Mitochondrial dysfunction is associated with increased risk of atherosclerosis by disrupting key cellular processes that contribute to premature vascular ageing. However, the specific role mitochondrial in early-onset coronary artery disease (EOCAD), which increasing at a particularly alarming rate, remains largely unexplored. This study investigated association leukocyte mtDNA-CN and mtDNA4977 deletion EOCAD. The included 118 patients (99 men, 51.0 ± 5.6 years) angiographically EOCAD (≤60 150 healthy controls (94 49.8 5.8 years). Quantitative RT-PCR was used quantify rate. group had higher prevalence male gender (p < 0.001), smoking = hypertension diabetes mellitus 0.04) obesity 0.001) than controls. lower 0.026). Low levels were significantly 0.004), 0.039), hypercholesterolemia 0.001). Increased males 0.026) hypercholesterolemic ROC curve predicting showed an AUC 0.902 (95% CI 0.867-0.937, p 0.762 0.691-0.834, respectively. Logistic regression analysis adjusted for confounders both independent significant predictors 0.001 0.001, respectively). characterized high modifiable factors damage, underscoring need more efforts reduce burden traditional highlighting potential innovative mitochondrial-targeted therapies.

Language: Английский

Citations

0
Risk Factors and Genetic Insights into Coronary Artery Disease-Related Sudden Cardiac Death: A Molecular Analysis of Forensic Investigation DOI Open Access

Xiangwang He,

Linfeng Li, Dongkai Zhou

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3470 - 3470

Published: April 8, 2025

Sudden cardiac death (SCD) is a major cause of mortality among patients with coronary artery disease (CAD). This study aimed to identify risk factors for CAD-related SCD (SCDCAD) through autopsy data and genetic screening particular emphasis on rare variants (minor allele frequency < 0.01). We included 241 SCDCAD cases (mean age 54.6 ± 12.8 years, 74.7% male) verified by medico-legal examination silent CAD controls 53.6 15.2 25.3% female) who died from severe craniocerebral trauma. Information about characteristics was obtained questionnaires, police reports data. Whole-exome sequencing performed myocardial tissue samples. Polygenic score (PRS) previously validated model applied variant pathogenicity predicted using in silico tools. victims predominantly at night showed higher rates during summer winter months, more complex disease. Nocturnal time (adjusted odds ratio [AOR] = 3.53, 95% CI: 2.37–5.25, p 0.001), (AOR 2.06, 1.33–3.20, multiple vessel occlusion 1.79, 1.16–2.77, 0.009), right stenosis 2.38, 1.54–3.68, 0.001) unstable plaque 2.17, 1.46–3.23, were identified as SCDCAD. The PRS associated 60% increased (OR 1.632 per SD, 95%CI: 1.631–1.633, 0.001). Genetic analysis MUC19 CGN being both hereditary acquired that may contribute dysfunction precipitate patients, thereby facilitating the prevention early recognition high-risk individuals.

Language: Английский

Citations

0
Healthy eating behaviors may be associated with lower risk of premature coronary artery disease: A multi-center case-control study DOI Creative Commons

Ehsan Shirvani,

Noushin Mohammadifard,

Mansour Keshavarz

et al.

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 20, 2025

Despite some evidence on individual eating habits in relation to cardiovascular disease, little is known about the combination of common premature coronary artery disease (PCAD). We investigated association between a combined score (EHS) and PCAD risk. In this case-control study, 2022 patients with 1063 healthy control were recruited. Women aged 18 70 men 60 years eligible. was defined as 75% or more stenosis single at least 50% left main artery. Eating assessed through interview higher scores represent healthier behaviors. Participants fourth quartile EHS had 22% lower risk than those first (95% CI: 0.61, 0.99; P = 0.024). Not adding salt table (OR 0.80, 95% 0.66, 0.97; 0.023), low-salt meals 0.75, 0.57, 0.022), slow 0.42, 0.24, 0.71; < 0.001) associated while water drinking 1.56, 1.07, 2.27; 0.013), increased meal frequency 1.85, 1.09, 3.13; 0.025) linked PCAD. Healthy behaviors score, particularly low intake However, Well-designed prospective cohort studies are required.

Language: Английский

Citations

0
Toward personalized medicine in patients with familial hypercholesterolemia DOI
Hayato Tada, Masayuki Takamura

Atherosclerosis, Journal Year: 2024, Volume and Issue: 397, P. 118522 - 118522

Published: June 18, 2024

Language: Английский

Citations

0
Features of the monocyte inflammatory response in patients with premature coronary artery disease DOI Creative Commons
Tatiana Blokhina, Tatiana V. Kirichenko, Yuliya V. Markina

et al.

Biophysics Reports, Journal Year: 2024, Volume and Issue: 11(1), P. 12 - 12

Published: Sept. 13, 2024

The purpose of this study was to examine the secretion inflammatory cytokines by cultured monocytes/macrophages in patients with premature coronary artery disease (CAD). included 38 CAD and 35 without CAD. A primary culture CD14+ monocytes obtained immunomagnetic separation. response induced incubation a cell lipopolysaccharide (LPS) for 24 hours on Days 1 6. Basal LPS-stimulated cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) monocyte chemotactic protein-1 (MCP-1) assessed enzyme immunoassay 2 7 cultivation. level basal TNF-α, IL-1β, IL-6, MCP-1 higher compared control group. levels re-stimulated TNF-α IL-1β second sixth days were also day did not differ both groups, but results logistic regression analysis showed that IL-6 independently associated CAD, along smoking, body mass index serum HDL-cholesterol levels.

Language: Английский

Citations

0
EF24, a Curcumin Analog, Reverses Interleukin-18-Induced miR-30a or miR-342-Dependent TRAF3IP2 Expression, RECK Suppression, and the Proinflammatory Phenotype of Human Aortic Smooth Muscle Cells DOI Creative Commons
Yusuke Higashi, Ryan J. Dashek, Patrice Delafontaine

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1673 - 1673

Published: Oct. 10, 2024

Curcumin, a polyphenolic compound derived from the widely used spice

Language: Английский

Citations

0
Correlation between remnant cholesterol and premature coronary artery disease and the severity of coronary artery lesions in men: a retrospective study DOI Creative Commons
Xiaoxiao Dong, Ke Chen, Xiuqin Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 25, 2024

To investigate the correlation between remnant cholesterol (RC) and premature coronary artery disease (PCAD) severity of lesions in men.

Language: Английский

Citations

0
Prevalence and Correlators of Anxiety and Depression in Premature Coronary Artery Disease DOI Creative Commons

Cangtuo Li,

Qiqi Hou, Quanle Han

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5807 - 5815

Published: Dec. 1, 2024

Purpose: The present study assessed the correlation between anxiety and depression in young middle-aged Chinese patients with coronary artery disease (CAD). Patients Methods: This included 313 diagnosed premature CAD at Department of Cardiology January July 2023. Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) was used as a standardized scale to assess mental health symptoms. A binary logistic regression model (backward) analyze CAD. Results: Anxiety observed 154 persons prevalence 49.20%, median SAS score 53.0 (52.00– 54.00). Depression 91 patients, 29.07%, SDS 55.00 (54.00– 57.00). total 63 (20.13%) had comorbid depression. Multivariate analysis revealed that positively associated severe stenosis, systolic blood pressure (SBP), body mass index, snoring. However, it is negatively high-income levels. age, SBP. Comorbid were Conclusion: For first time, we investigated correlators Therefore, emotional status should be routinely evaluated both primary specialized care services. Keywords: Cardiovascular disease, anxiety,

Language: Английский

Citations

0
A Synergistic Effect of Remnant Cholesterol and C-Reactive Protein on Predicting the Severity of Coronary Artery Disease DOI Creative Commons
Zhen Zhang, Qiang Chen, Qiping Chen

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11291 - 11303

Published: Dec. 1, 2024

Increased levels of remnant cholesterol (RC) and inflammation are linked to higher risks atherosclerotic cardiovascular disease. Whether a combination C-reactive protein (CRP) RC improves the predictive ability for evaluating severity coronary artery lesions remains unknown. A total 1675 patients with disease were stratified according Synergy Between Percutaneous Coronary Intervention (SYNTAX) score (SYNTAX ≤22 versus SYNTAX >22). Logistic regression restricted cubic spline models used evaluate relationship between RC, CRP lesions. Multivariate logistic was identify predictors mid/high The value combined estimated by ROC curve, continuous net reclassification improvement (NRI) integrated discrimination (IDI). multivariable-adjusted odds ratios (95% CIs) highest lowest quartile 2.143 (1.450-3.166) association maintained significant in subsample patients, regardless traditional risk factors like LDL-C glycemic metabolism status. Moreover, addition baseline model had an incremental effect on (increase C‑statistic from 0.650 0.698; IDI 0.03; NRI 0.306; all P < 0.01). Elevated significantly associated even optimal low-density lipoprotein levels. Adjustment further improved might serve as noninvasive predictor CAD complexity could potentially influence management therapeutic approach.

Language: Английский

Citations

0