Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 1055 - 1055
Published: Oct. 11, 2024
To assess the incidence and temporal trend of type 1 diabetes (T1D) diabetic ketoacidosis (DKA) during period 2014-2023 in youths aged 0-14 years Trentino-Alto Adige region, Italy.
Language: Английский
Diabetologia, Journal Year: 2024, Volume and Issue: 67(4), P. 623 - 640
Published: Feb. 13, 2024
Language: Английский
Citations
9
Journal of Paediatrics and Child Health, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
ABSTRACT Type 1 diabetes (T1D) has two pre‐symptomatic phases (stages and 2) with progressive destruction of beta cells which have been identified through longitudinal cohort studies in recent decades. The definition T1D, hyperglycaemia that may or not be symptomatic, is now defined as stage 3. There growing evidence screening for stages 2 reduces rates diabetic ketoacidosis prevents long‐term complications. These can by the presence islet autoantibodies are markers autoimmune cell damage. Furthermore, genetic risk scores, combine a variety single nucleotide polymorphisms, identify people at high future T1D. Thus, they provide an opportunity to select high‐risk individuals autoantibody testing. Individuals having T1D require ongoing monitoring detect need insulin replacement. also eligible emerging immunotherapies delay progression This review article explores current summarises recommended clinical care early‐stage
Language: Английский
Citations
1
PubMed, Journal Year: 2023, Volume and Issue: 22, P. 1235 - 1263
Published: Jan. 1, 2023
Hesperidin and hesperetin, two flavonoids with potential therapeutic value, have been extensively studied in the context of diabetes management. The main objective this research is to ascertain their as options for managing its complications. present study utilized a systematic review methodology comprehensively explored relevant literature from databases, including PubMed, Scopus, Web Science, inception until July 2023. summarized outcomes related molecular, cellular, metabolic effects hesperidin hesperetin Hesperetin exhibits treatment preventing associated complications through modulation inflammatory cytokine release expression via pathway signaling Toll-like receptor/Myeloid differentiation factor 88/Nuclear factor-kappa B. shows promise biomolecule treating diabetic neuropathy, primarily activation nuclear erythroid 2-related 2 (Nrf-2), an antioxidant-response element signaling, leading neuroprotective effects. Both compounds demonstrated ability normalize blood glucose levels reduce serum liver lipid levels, making them candidates hypoglycemia hypolipidemia diabetes. also showed benefits against nephropathy by suppressing transforming growth factor-β1-integrin-linked kinase-Akt enhancing renal function. Furthermore, hesperidin's antioxidant, anti-inflammatory, anti-depressant conditions expanded applications. This provides substantial evidence supporting consideration It offers exciting possibilities developing novel, cost-effective enhance management patient outcomes.
Language: Английский
Citations
11
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 15, 2024
Blood glucose monitoring constitutes a pivotal element in the clinical management of Type 1 diabetes (T1D), globally escalating metabolic disorder. Continuous (CGM) devices have demonstrated efficacy optimizing glycemic control, mitigating adverse health outcomes, and augmenting overall quality life for individuals afflicted with T1D. Recent progress field encompasses refinement electrochemical sensors, which enhances effectiveness blood monitoring. This empowers patients to assume greater control over their health, alleviating burdens associated condition, contributing alleviation healthcare system. The introduction novel medical devices, whether derived from existing prototypes or originating as innovative creations, necessitates adherence rigorous approval process regulated by Food Drug Administration (FDA). Diverse device classifications, stratified risks, dictate distinct pathways, each characterized varying timelines. review underscores recent advancements primarily based on sensors elucidates regulatory journey towards FDA approval. advent innovative, non-invasive holds promise maintaining stringent thereby preventing T1D-associated comorbidities, extending expectancy affected individuals.
Language: Английский
Citations
4
Archives of Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 68
Published: Jan. 1, 2024
The aim of this study was to assess the efficacy and safety hybrid closed-loop (HCL) systems for insulin delivery in children adolescents with type 1 diabetes (T1D). We searched Embase, PubMed, Cochrane Library randomized controlled trials (RCTs) published until March 2023 comparing HCL therapy control therapies T1D. computed weighted mean differences (WMDs) continuous outcomes risk ratios (RRs) 95% confidence intervals (CIs) binary endpoints. [...]
Language: Английский
Citations
4
Current Diabetes Reports, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 24, 2025
Abstract Purpose of Review The prevalence diabetes is rising around the world and represents an important public health concern. Unlike individual-level risk protective factors related to etiology diabetes, contextual have been much less studied. Identification type 1 2 in Organisation for Economic Co-operation Development (OECD) countries may help professionals, researchers, policymakers improve surveillance, develop policies programs, allocate funding. Recent Findings Among 4,470 potential articles, 48 were included this review. All reviews published English between 2005 2023 conducted over 20 different countries. This review identified ten upstream risk, including income, employment, education, immigration, race/ethnicity, geography, rural/urban status, built environment, environmental pollution, food security/environment. Summary be integrated into research, surveillance prevention activities promote better outcomes people at or living with OECD Additional research needed quantify measures associations emerging key outcomes.
Language: Английский
Citations
0
SAGE Open, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 1, 2025
Diabetes prevalence is steadily increasing in Europe. This study aims to compare diabetes and the existence of related socioeconomic inequalities between 19 European countries. Using data from The Social Survey (ESS), there were 31,178 participants (53.06% women) aged 25+ years Austria, Belgium, Czechia, Denmark, Finland, France, Germany, Hungary, Ireland, Lithuania, Netherlands, Norway, Poland, Portugal, Slovenia, Spain, Sweden, Switzerland United Kingdom. Education level employment used as indicators inequalities. Logistic regression analyses calculated predict by controlling for age gender. Differences effect size education on countries then further examined. Overall Europe was reported be 6.12%, higher Eastern Southern than Northern Western Additionally, men had a risk reporting having compared women. Employment identified protective factor against development across all regions. Moreover, individuals with tertiary lower most regions except region. Participants levels unemployed ones chance diabetes. found some
Language: Английский
Citations
0
Pediatric Diabetes, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Objective: Adolescents managing type 1 diabetes (T1D) are at increased risk of experiencing eating disorders (EDs). Identifying factors is essential to develop preventive strategies. This study examines the potential mediation value self‐esteem and perfectionism associated with EDs in relationship between sociocultural attitudes toward appearance related a sample adolescents T1D. Methods: Forty‐six aged 12–17 years diagnosed T1D participated current study. Sociocultural appearance, EDs, were measured. Multiple simple mediator analyses using bootstrapping method bias‐corrected confidence estimates conducted. Results: Our results show that problems not only attitudes, but rather these last two variables would be fully mediated by perfectionism. Conclusions: A high degree could variable when developing adolescents. Perfectionism its self‐management prominent factor may help design interventions developed for who behaviors potentially conflict eating. The clinical implications discussed.
Language: Английский
Citations
0
Intelligent Pharmacy, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 26, 2025
Post-translational modifications such as SUMOylation are crucial for the functionality and signal transduction of a diverse array proteins. Analogous to ubiquitination, has garnered significant attention from researchers been implicated in pathogenesis various human diseases recent years, cancer, neurological lesions, cardiovascular diseases, diabetes mellitus, so on. The diabetes, particularly type 1 2 closely associated with immune dysfunction, which constitutes primary focus this review. This review will elucidate process its impact on mellitus development complications, focusing regulatory effects microenvironment. article summarizes signaling pathways at both cellular molecular levels that these processes. Furthermore, it proposes potential new targets drug aimed prevention treatment based insights gained process.
Language: Английский
Citations
0