Antidiabetic drug administration prevents bone mineral density loss: Evidence from a two-sample Mendelian randomization study DOI Creative Commons
Mingzhu Chen,

Shuisen Lin,

Wanqiong Chen

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0300009 - e0300009

Published: March 7, 2024

The aim of this study was to investigate the effect common antidiabetic drugs on BMD by two-sample Mendelian randomization (MR). single nucleotide polymorphisms that were strongly associated with insulin, metformin, rosiglitazone and gliclazide extracted as instrumental variables (IVs) for MR analysis. inverse variance weighted (IVW) method used primary assess causal BMD, other methods, including Weighted median, Egger mode, complementary Reliability stability assessed leave-one-out test. In present work, IVW estimation insulin heel demonstrated there a null (β = 0.765; se 0.971; P 0.430), while metformin treatment had positive 1.414; 0.460; 2.118*10 −3 ). relationship between analysed suggested -0.526; 1.744; 0.763), but evaluated 2.671; 1.340; 0.046). summary, work showed have role in reducing loss patients diabetes are recommended prevention diabetes.

Language: Английский

Association of Dietary Intake with Chronic Disease and Human Health DOI Open Access
Domenico Tafuri, Francesca Latino

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 446 - 446

Published: Jan. 26, 2025

Eating habits are among the major determinants of health, and in most countries world part population suffers from one or more problems related to malnutrition, by default (due an acute chronic lack micronutrients) excess (energy, sugars, fats, deficiencies important [...]

Language: Английский

Citations

0
Knowledge and awareness of Palestinian health care professionals towards probiotics, prebiotics and synbiotics: a cross-sectional study from Palestine DOI Creative Commons
Abdel Naser Zaid, Iyad Ali, Nidal Jaradat

et al.

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Probiotics are live microorganisms believed to confer health benefits when consumed appropriately. Prebiotics non-digestible food components that promote by encouraging the growth or activity of beneficial microorganisms. Synbiotics a combination probiotics and prebiotics. This study aimed assess knowledge awareness Palestinian healthcare professionals regarding probiotics, prebiotics, synbiotics. A cross-sectional was conducted across West Bank using structured questionnaire, descriptive analysis performed SPSS. The results indicated 68.5% physicians 83.4% pharmacists were aware whereas only 37% 48% had Awareness synbiotics even lower, with 20% 26.6% reporting familiarity. These findings suggest while there is reasonable level about prebiotics significantly lacking, which limits their use. Enhancing these products could be facilitated through workshops, ongoing education, involvement medical representatives.

Language: Английский

Citations

0
Physical activity with or without dietary intervention for the prevention of cardiovascular diseases DOI Creative Commons
Carl J. Lavie, Salvatore Carbone, Leandro Slipczuk

et al.

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2024, Volume and Issue: 13(6), P. 753 - 755

Published: May 29, 2024

Language: Английский

Citations

1
Evaluation of Cardiovascular Disease Risk in Patients with Type 2 Diabetes Mellitus Using Clinical Laboratory Markers DOI Open Access

Battamir Ulambayar,

Amr Sayed Ghanem, Chau Minh Nguyen

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3561 - 3561

Published: June 18, 2024

Background: Cardiovascular diseases (CVD) are the main cause of death in population with diabetes mellitus. This study purposed to determine clinical laboratory markers that might be correlated risk CVD individuals type 2 mellitus (T2DM). Methods: Using data from Clinical Center University Debrecen 2016 2020, we assessed cardiovascular 5593 T2DM over a five-year follow-up period. There were 347 new cases acute myocardial infarction (AMI) and stroke during Following stratification these into two groups according diagnosis CVDs until was through utilization Chi-square test Cox proportional hazards regression. Results: The findings regression model showed number HbA1C measurements per year (HR = 0.46, 95% CI 0.31-0.7), decreased levels estimated glomerular filtration rate (eGFR) 1.6, 1.04-2.47), elevated triglyceride 1.56, 1.06-2.29) patients T2DM. area under curve (AUC) increased 0.557 (95% 0.531-0.582) 0.628 0.584-0.671) after inclusion variables showing improved discrimination for AMI stroke. Conclusions: These indicated eGFR, triglyceride,

Language: Английский

Citations

1
Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies DOI Creative Commons

Nawfal Hasan Siam,

Nayla Nuren Snigdha,

Noushin Tabasumma

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(12)

Published: Dec. 11, 2024

Diabetes mellitus (DM) affects 537 million people as of 2021, and is projected to rise 783 by 2045. This positions DM the ninth leading cause death globally. Among patients, cardiovascular disease (CVD) primary morbidity mortality. Notably, prevalence rates CVD alarmingly high among diabetic individuals, particularly in North America Caribbean (46.0%), Southeast Asia (42.5%). The predominant form patients coronary artery (CAD), accounting for 29.4% cases. pathophysiology complex, involving insulin resistance, β-cell dysfunction, associated complications including cardiomyopathy (DCM) autonomic neuropathy (CAN). These conditions exacerbate risks underscoring importance managing key risk factors hypertension, dyslipidemia, obesity, genetic predisposition. Understanding networks molecular processes that link diabetes can lead new diagnostics therapeutic interventions. Imeglimin, a novel mitochondrial bioenergetic enhancer, represents promising medication with potential address both resistance secretion difficulties. Effective management through oral hypoglycemic agents (OHAs) protect system. Additionally, certain antihypertensive medications significantly reduce diabetes-related CVD. lifestyle changes, diet exercise are vital diabesity reducing risks. interventions, along emerging ongoing clinical trials, offer hope improved patient outcomes long-term remission. study highlights urgent need strategies overlapping epidemics By elucidating underlying mechanisms factors, this aims guide future perspectives enhance understanding pathogenesis DM, thereby guiding more effective treatment strategies.

Language: Английский

Citations

1
Antidiabetic drug administration prevents bone mineral density loss: Evidence from a two-sample Mendelian randomization study DOI Creative Commons
Mingzhu Chen,

Shuisen Lin,

Wanqiong Chen

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0300009 - e0300009

Published: March 7, 2024

The aim of this study was to investigate the effect common antidiabetic drugs on BMD by two-sample Mendelian randomization (MR). single nucleotide polymorphisms that were strongly associated with insulin, metformin, rosiglitazone and gliclazide extracted as instrumental variables (IVs) for MR analysis. inverse variance weighted (IVW) method used primary assess causal BMD, other methods, including Weighted median, Egger mode, complementary Reliability stability assessed leave-one-out test. In present work, IVW estimation insulin heel demonstrated there a null (β = 0.765; se 0.971; P 0.430), while metformin treatment had positive 1.414; 0.460; 2.118*10 −3 ). relationship between analysed suggested -0.526; 1.744; 0.763), but evaluated 2.671; 1.340; 0.046). summary, work showed have role in reducing loss patients diabetes are recommended prevention diabetes.

Language: Английский

Citations

0