Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities DOI Creative Commons
Laura Comi, Claudia Giglione, Fationa Tolaj

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

ABSTRACT This comprehensive investigation delves into the interconnectedness of different features cardiometabolic syndrome, such as metabolic dysfunction‐associated steatotic liver disease (MASLD), atherosclerotic cardiovascular (ASCVD), and gut dysbiosis, highlighting crucial role nutraceuticals in their management prevention. Given significant overlap pathophysiology these conditions, treatment with nutraceuticals, especially those derived from agro‐food waste, offers a promising, sustainable, innovative approach to healthcare. The 2030 Agenda for Sustainable Development One Health concept are key frameworks selecting most interesting supply chain production ensuring environmental sustainability, agricultural practices. In this review, therapeutic potential kiwifruit apples has been explored, detailing how bioactive compounds, like polyphenols, fiber, pectin, kaempferol, phloretin, phlorizin, may contribute MASLD, ASCVD, dysbiosis. Various extraction methods active ingredients, including chemical, water, enzyme extractions, analyzed respective benefits drawbacks. By integrating scientific research, sustainable practices, methods, we can develop effective strategies combat pervasive health issues. holistic not only enhances individual outcomes but also supports broader societal goals, promoting healthier future all.

Language: Английский

Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk: a comprehensive review DOI Creative Commons

Haixiang Zheng,

Leonardo A. Sechi, Eliano Pio Navarese

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 28, 2024

Language: Английский

Citations

14
Metabolic syndrome traits differentially and cumulatively influence micro‐ and macrovascular disease risk in patients with MASLD DOI Creative Commons
Alex E. Henney, David R. Riley, Theresa Hydes

et al.

Liver International, Journal Year: 2024, Volume and Issue: 44(11), P. 3031 - 3049

Published: Sept. 2, 2024

Abstract Introduction The cumulative impact of metabolic syndrome (MetS) components on micro‐ and macrovascular disease in dysfunction‐associated steatotic liver (MASLD) is unclear. We aimed to determine whether the number MetS increases risk patients with MASLD. Methods performed a retrospective cohort study electronic medical records using TriNetX network, global federated database. exposure arm was hepatic steatosis (defined via International Classification Diseases, 10th Revision coding, or modified index), ≥1 (obesity/central adiposity, insulin resistance, hypertension, dyslipidaemia), compared reference adults without any steatosis. Our propensity score matched (1:1) for confounders 5 years follow‐up. Primary outcomes included microvascular (peripheral neuropathy, retinopathy, nephropathy) (cardiovascular events, cerebrovascular accidents, peripheral vascular disease) disease. Secondary analyses assessed additional these outcomes, as well sex. Results MASLD, defined by resistance ( n = 15 937), carried highest (HR 13.93 (95% CI 8.55–22.68)), whilst hypertension 53 028), (7.23 (6.45–8.13)). MASLD all greatest both (31.20 (28.88–33.70) 462 789)) (8.04 (7.33–8.82) 336 010)) Conclusion demonstrate differential effect multiple overall risk. most pronounced women. Aggressive factor management critical prevention complications.

Language: Английский

Citations

4
Effect of Oral Microbiota Composition on Metabolic Dysfunction-Associated Steatotic Liver Disease in the General Population DOI Open Access
Satoshi Sato, Chikara Iino,

K. Furusawa

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2013 - 2013

Published: March 16, 2025

Background/Objective: This study investigated the relationship between composition of oral microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD) in general population. Methods: In total, 712 participants a health check-up project were divided into four patterns by principal component analysis cluster analysis; they included Neisseria, Streptococcus, Fusobacterium, Veillonella groups. The Neisseria group had largest number patients was used as reference to compare incidence MASLD cardiometabolic criteria with other Results: multivariate analysis, risk factor for independent compared group. correlation bacterial species MASLD-related items showed that negatively correlated controlled attenuation parameters, body mass index, waist circumference, hemoglobin A1c, alanine aminotransferase, fatty index. positive blood pressure, triglycerides, aspartate gamma-glutamyl transpeptidase, negative high-density lipoprotein cholesterol. contrast, Streptococcus Fusobacterium groups not clearly associated MASLD. Conclusions: Maintaining hygiene preventing periodontitis may contribute extending healthy lifespan.

Language: Английский

Citations

0
Lean MASLD and Cardiovascular Disease: A Review DOI

Nachum Lebovics,

Gabriel Heering,

William H. Frishman

et al.

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Metabolic-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty disease, is prevalent worldwide and highly associated with cardiovascular (CVD). Lean MASLD defined by hepatic steatosis cardiometabolic risk factors in individuals a body mass index below 25 Western populations or 23 Asian populations. Paradoxically, some studies indicate that lean an elevated of (CV) CV mortality compared nonlean MASLD. patients exhibit distinctive metabolic, genetic, microbiome profiles contributing to increased visceral adiposity, sarcopenia, fibrosis, systemic inflammation, endothelial dysfunction. This review examines the epidemiology, pathophysiology, outcomes MASLD, addressing discrepancies literature. Furthermore, it highlights current clinical guidelines, emphasizes lifestyle modifications, discusses emerging pharmacotherapies potential treatment options.

Language: Английский

Citations

0
Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study DOI Creative Commons
Giuseppe Lisco, Davide Guido,

Nicole Cerabino

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Language: Английский

Citations

0
From MASLD to PAD: Looking for Cardiovascular Disease Starting from Metabolic Status DOI Creative Commons
Andrea Boccatonda, Damiano D’Ardes, Veronica Moronti

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1781 - 1781

Published: Oct. 31, 2024

Peripheral artery disease (PAD) is still the least studied and evaluated form in clinical practice among atherosclerotic pathologies, despite increased mortality comorbidities related to it. The relationship between steatotic liver an risk of cardiovascular has been extensively documented.

Language: Английский

Citations

2
Sex differences in pathogenesis and treatment of dyslipidemia in patients with type 2 diabetes and steatotic liver disease DOI Creative Commons

Tatjána Ábel,

Béla Benczúr, Éva Csajbókné Csobod

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 23, 2024

Previously published studies have shown that women with type 2 diabetes a higher risk of atherosclerotic cardiovascular disease than men diabetes. The exact reason for this is not yet known. association between metabolic dysfunction-associated steatotic liver and appears to be bidirectional, meaning the onset one may increase progression other. Dyslipidemia common in both diseases. Our aim was therefore investigate whether there sex difference pathogenesis management dyslipidemia patients dysfunction. While majority date found no statin treatment, some reduced effectiveness compared men. Statin treatment under-prescribed diabetics disease. No differences were ezetimibe treatment. However, best our knowledge, such study fibrate Conflicting results on efficacy newer cholesterol-lowering PCSK9 inhibitors been reported Results from two real-world suggest up-titration dose improves women. Bempedoic acid has effective safe more lipid lowering men, based phase 3 date. Further research needed clarify plays role ASCVD

Language: Английский

Citations

1
Metabolic dysfunction-associated fatty liver disease: bridging cardiology and hepatology DOI Creative Commons
Xiaodong Zhou, Giovanni Targher, Christopher D. Byrne

et al.

Cardiology Plus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic diseases, affecting approximately 30% global adult population, with a rise largely attributed to increasing rates obesity and diabetes worldwide. Historically, term “NAFLD” did not explicitly link condition its most common causes, such as diabetes, or principal pathophysiological mechanisms, including insulin resistance low-grade metabolic inflammation. This semantic laxity potentially reduced attempts at screening, diagnosis, management. The shift using terms metabolic-associated (MAFLD) dysfunction-associated steatotic (MASLD) reflects more accurate understanding condition’s origins highlights broader implications, particularly cardiovascular diseases. MAFLD/MASLD represents convergence point between hepatology cardiology, dysfunction serving bridge pathology increased risk. Growing clinical evidence reveals strong association morbidity mortality. Despite this, risks associated are often underestimated, especially among cardiologists. narrative review explores potential implications for cardiology practice, examining diagnostic criteria, risk assessment, adjustments in collaborative care strategies, treatment options, directions future research.

Language: Английский

Citations

1
Exploring the Th2 Response in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Potential Modulator of the Renin-Angiotensin System (RAS) Pathway in Hypertension Development DOI Creative Commons
Lucia A. Méndez‐García, Galileo Escobedo,

Itzel Baltazar-Pérez

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1080 - 1080

Published: Aug. 29, 2024

Non-alcoholic fatty liver disease (NAFLD), now referred to as metabolic dysfunction-associated steatotic (MASLD), is alarmingly increasing alongside the cases of obesity worldwide. MASLD an underestimated abnormality closely linked with a higher risk developing systemic arterial hypertension (SAH). However, underlying mechanism association between and SAH remains unknown. Inflammation may link these two entities by regulating renin-angiotensin system (RAS). For this reason, in study, we evaluated hepatic expression cytokine profile critical molecules RAS pathway patients morbid MASLD, both SAH. We found statistically significant correlation ACE levels cytokines IL-4, IL-10, IL-13 Th2 response. Furthermore, according multiple linear regression analysis, IL-4 were best predictors levels. Moreover, observed increased obesity, compared those without These results allow us propose, for first time, that response, through RAS, could play role individuals obesity.

Language: Английский

Citations

0
Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities DOI Creative Commons
Laura Comi, Claudia Giglione, Fationa Tolaj

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

ABSTRACT This comprehensive investigation delves into the interconnectedness of different features cardiometabolic syndrome, such as metabolic dysfunction‐associated steatotic liver disease (MASLD), atherosclerotic cardiovascular (ASCVD), and gut dysbiosis, highlighting crucial role nutraceuticals in their management prevention. Given significant overlap pathophysiology these conditions, treatment with nutraceuticals, especially those derived from agro‐food waste, offers a promising, sustainable, innovative approach to healthcare. The 2030 Agenda for Sustainable Development One Health concept are key frameworks selecting most interesting supply chain production ensuring environmental sustainability, agricultural practices. In this review, therapeutic potential kiwifruit apples has been explored, detailing how bioactive compounds, like polyphenols, fiber, pectin, kaempferol, phloretin, phlorizin, may contribute MASLD, ASCVD, dysbiosis. Various extraction methods active ingredients, including chemical, water, enzyme extractions, analyzed respective benefits drawbacks. By integrating scientific research, sustainable practices, methods, we can develop effective strategies combat pervasive health issues. holistic not only enhances individual outcomes but also supports broader societal goals, promoting healthier future all.

Language: Английский

Citations

0