Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population DOI Creative Commons
Chiara Pavanello, Massimiliano Ruscica,

Sofia Castiglione

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Abstract Background The triglyceride-glucose (TyG) index is now widely recognized as a marker of insulin resistance and has been linked to the development prognosis atherosclerotic cardiovascular diseases (ASCVD) in numerous populations, particularly Eastern world. Although there are fewer reports from Western world, they sometimes contradictory, absence definitive data on relationship between raised TyG risk suggested opportunity testing this biochemical against well-established vascular such carotid intima media thickness (c-IMT). Methods Primary prevention patients were selected cohort individuals who underwent c-IMT measurement 1984 2018 at Dyslipidemia Center ASST Grande Ospedale Metropolitano Niguarda Milan, Italy. was calculated Ln [fasting TG (mg/dL)×fasting glucose (mg/dL)/2]. Carotid ultrasonography performed using echographic measurements far walls left right common, internal carotids, bifurcations. Patients followed for up 20 years with periodic evaluation parameters. ASCVD events monitored through hospital records, where all regularly examined. Results analysis included 3108 mean age 54.9 ± 13.1 years. Participants generally non-obese, an average BMI 24.6 3.5 Kg/m 2 . Among women, 83.1% postmenopausal. 8.65 0.59. There significant association measurements. Those highest quartiles had significantly higher IMT max compared those lower quartiles. These associations consistent across sites examined remained after adjusting potential confounders. Kaplan-Meier survival revealed increased incidence two Conclusions sensitive European population moderate risk, assessed by measurements, large Lipid Clinic patients.

Language: Английский

Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population DOI Creative Commons
Chiara Pavanello, Massimiliano Ruscica,

Sofia Castiglione

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Abstract Background The triglyceride-glucose (TyG) index is now widely recognized as a marker of insulin resistance and has been linked to the development prognosis atherosclerotic cardiovascular diseases (ASCVD) in numerous populations, particularly Eastern world. Although there are fewer reports from Western world, they sometimes contradictory, absence definitive data on relationship between raised TyG risk suggested opportunity testing this biochemical against well-established vascular such carotid intima media thickness (c-IMT). Methods Primary prevention patients were selected cohort individuals who underwent c-IMT measurement 1984 2018 at Dyslipidemia Center ASST Grande Ospedale Metropolitano Niguarda Milan, Italy. was calculated Ln [fasting TG (mg/dL)×fasting glucose (mg/dL)/2]. Carotid ultrasonography performed using echographic measurements far walls left right common, internal carotids, bifurcations. Patients followed for up 20 years with periodic evaluation parameters. ASCVD events monitored through hospital records, where all regularly examined. Results analysis included 3108 mean age 54.9 ± 13.1 years. Participants generally non-obese, an average BMI 24.6 3.5 Kg/m 2 . Among women, 83.1% postmenopausal. 8.65 0.59. There significant association measurements. Those highest quartiles had significantly higher IMT max compared those lower quartiles. These associations consistent across sites examined remained after adjusting potential confounders. Kaplan-Meier survival revealed increased incidence two Conclusions sensitive European population moderate risk, assessed by measurements, large Lipid Clinic patients.

Language: Английский

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