Cardioprotection strategies for anthracycline cardiotoxicity

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities manifestation severity immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. To elucidate whether affect ICI-induced cardiotoxicity, we randomized 17-month-old male female mice to receive control diet (CON) or high-fat (HFD) + L-NAME-a well-established mouse model co-morbidities-for 17 weeks (n = 5-7), evaluated markers T-cell function in spleen. As expected, HFD L-NAME significantly increased body- heart weight, serum cholesterol levels, caused no systolic dysfunction, however, led diastolic cardiomyocyte hypertrophy, fibrosis only males compared corresponding CON. Western blot analyses splenic protein levels showed differential expression depending co-morbidities, suggesting exhaustion both sexes L-NAME, but more pronounced males. In a sub-study with similar setup, tested cardiotoxic manifestations ICI by treating anti-PD-1 monoclonal antibody (ICI) for last 2 administration 5-7). After treatment, cardiac functions decreased CON, groups baseline (before administration). conclusion, this exploratory study using aged mice, describe first time that ICI-related dysfunction is diminished when obesity hypercholesterolemia are present, possibly due obesity-related exhaustion.

Language: Английский

Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Language: Английский