bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 22, 2024
Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, cognitive-enhancing effects nicotine, suggesting potential self-medication.
Language: Английский
Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
0
Indian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 67(3), P. 283 - 302
Published: March 1, 2025
Background: Cannabis has been associated with psychopathology since ancient times, but controversies continue despite important advances in the field. This article is fourth one our decadal series of review articles that have providing an update snapshot meandering journey research findings this area. Aims: narrative a comprehensive literature search over past 10 years aims to provide and current understanding, while raising unanswered questions for future, focusing on following areas: (a) nosological changes cannabis-related psychiatric syndromes; (b) newer category synthetic cannabinoids; (c) cannabis withdrawal syndrome); (d) psychosis; (e) mood disorders; (f) suicidality; (g) prenatal use offspring; (h) effect recent liberal policy overhaul control certain countries/areas adverse outcomes; (i) cognition; (j) cannabis, psychopathology, genetics. Methods: The data strategies involved combination electronic databases manual hand-searching relevant publications cross-references using selected terms. primary focused Medline PubMed Central extended such as Google Scholar, PsychINFO, Scopus, Ovid specific sections. Key references identified through searches provided additional material. Inclusion criteria spanned studies published between January 2014 June 2024, more emphasis placed (post-2020) ensuring historical coverage. Results: aimed be comprehensive, including broad range without strict methodological exclusions. Strengths limitations cited are discussed when applicable, maintaining consistency three prior reviews. We syndromes, human (rather than animal) studies, applied basic) research. only reference not entire area because would beyond scope article. There updates all areas covered. syndromal entities ICD-11, which also includes cannabinoids first time. syndrome better characterized. association psychosis robustly established especially very high-potency vulnerable populations, particularly young people. Work progress elucidating causal mechanisms. links disorders well suicidality cognitive impairment characterized, though remain. Recent liberalizing policies produced accidental (with deleterious effects offspring) later (mixed findings, documented increase emergency visits related use). will require active monitoring new data. Conclusion: field continues collect settle some old questions, address view wide worldwide its implications public health.
Language: Английский
Citations
0
Current Opinion in HIV and AIDS, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Purpose of review Human immunodeficiency virus (HIV) was historically considered a terminal illness. However, medical advancements, including antiretroviral therapy (ART), have extended the lifespan people with HIV (PWH), emphasizing importance maximizing quality life (QoL) in this aging population. These populations face unique health challenges due to various structural and environmental barriers, comorbidities. This aims consolidate recent data on pain management other palliative needs older (OPWH ). Recent findings research developments focus providing relief by incorporation geriatric care (PC) principles, use long-acting injectable-antiretroviral therapies (LAI-ARTs), cannabinoids, exercise self-management interventions, tailored cognitive-behavioral (CBT) for (OPWH; ≥50 years). The potential these novel interventions can fulfil underserved demographic suffering from niche subset physical psychosocial issues. Yet, there remains variability access services, disparities often linked healthcare infrastructure socioeconomic factors. Summary Interventions an population PWH should take person-centered approach, balancing different priorities exploring multiple avenues symptom relief.
Language: Английский
Citations
0
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102697 - 102697
Published: Feb. 1, 2025
Language: Английский
Citations
0
Current Opinion in Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Purpose of review Cognitive disorders persist in persons with HIV, despite virologically suppressive antiretroviral therapy. We summarize the current evidence on risk factors for cognitive decline HIV modern therapy-era. Recent findings consensus recommendations have proposed a new approach defining impairment which distinguishes true from low performance alone and considers both non-HIV-associated causes brain injury. Adverse mental health, risks associated substance misuse, an increasing burden age-related comorbidities been highlighted as important contributors toward this population. Aging may potentiate these through polypharmacy drug-drug interactions. Summary is likely multifactorial, contributions mechanisms, particularly comorbidities. With aging community screening be crucial to implement appropriate reduction strategies.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 22, 2024
Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, cognitive-enhancing effects nicotine, suggesting potential self-medication.
Language: Английский
Citations
0