Is There an Association Between Cigarette Smoking and Advanced Liver Fibrosis in Smokers with HIV, Heavy Drinking and High Prevalence of HCV?

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1169 - 1169

Published: Feb. 11, 2025

Background: Cigarette smoking has been associated with liver fibrosis in the setting of hepatitis C virus (HCV) infection but not studied among people HIV (PWH) who consume alcohol. Methods: This is a cross-sectional study PWH heavy drinking and daily St. Petersburg, Russia. The primary independent variable was past 30-day cigarettes per day (cpd), secondary pack-years at entry. Advanced defined as FIB-4 > 3.25. Analyses were adjusted for gender, body mass index (BMI), number days, HCV CD4 count. Results: Participants (n = 400) two-thirds male (67.3%), young (median age 38 years), lean BMI 22), antibody positive (84.5%) severely immune suppressed count 351). median past-month cpd 20 (IQR: 15–25), 24 17–31.8). prevalence advanced 11.3% (45/400). In logistic regression analyses, we did observe significant association between [middle (10.1–20 cigarettes) vs. lowest (5–10 category (adjusted odds ratio [aOR] (95% confidence interval [CI]): 1.06 (0.40–2.83), highest (>20.0 aOR CI): 0.65 (0.21–1.99), global p-value 0.62]. analysis yielded similar results (20.1–30 pack-years) (≤20 0.81 (0.33–1.99), (>30 0.91 (0.38–2.19); 0.58]. Conclusions: this Russian cohort PWH, detect an recent cigarette use or mean fibrosis.

Language: Английский

Recent developments of pyrimidine appended HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108273 - 108273

Published: Feb. 17, 2025

Language: Английский