Cancers,
Journal Year:
2021,
Volume and Issue:
13(4), P. 692 - 692
Published: Feb. 9, 2021
Neuroendocrine
plasticity
and
treatment-induced
neuroendocrine
phenotypes
have
recently
been
proposed
as
important
resistance
mechanisms
underlying
prostate
cancer
progression.
Treatment-induced
(t-NEPC)
is
highly
aggressive
subtype
of
castration-resistant
which
develops
for
one
fifth
patients
under
prolonged
androgen
deprivation.
In
recent
years,
understanding
molecular
features
phenotypic
changes
in
has
grown.
However,
there
are
still
fundamental
questions
to
be
answered
this
emerging
research
field,
example,
why
how
do
the
treatment-resistant
cells
acquire
neuron-like
phenotype.
The
advantages
change
role
tumor
microenvironment
controlling
cellular
emergence
forms
mostly
unknown.
Here,
we
discuss
functional
links
between
neurodevelopmental
processes
progression
treatment
resistance.
We
provide
an
overview
neurite-like
whether
reported
t-NEPC
pathways
proteins
relate
like
neurogenesis
axonogenesis
during
development
also
novel
therapeutic
targets
modulating
plasticity.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(2), P. 247 - 247
Published: Feb. 9, 2021
While
a
protein
primary
structure
is
determined
by
genetic
code,
its
specific
functional
form
mostly
achieved
in
dynamic
interplay
that
includes
actions
of
many
enzymes
involved
post-translational
modifications.
This
versatile
repertoire
widely
used
cells
to
direct
their
response
external
stimuli,
regulate
transcription
and
localization
keep
proteostasis.
Herein,
modifications
with
evident
potency
drive
prostate
cancer
are
explored.
A
comprehensive
list
proteome-wide
single
involvement
phenotypic
outcomes
presented.
Specifically,
the
data
on
phosphorylation,
glycosylation,
ubiquitination,
SUMOylation,
acetylation,
lipidation
collected.
type
knowledge
especially
valuable
cases
when
do
not
differ
expression
or
mutational
status
protein,
but
differential
activity
regulated
level
Since
driving
roles
cancer,
studied
attempts
advance
treatment.
Current
strategies
exploit
potential
therapy
Cancer Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 20
Published: June 5, 2023
Prostate
cancer,
one
of
the
most
frequently
occurring
cancers
in
men,
is
a
heterogeneous
disease
involving
multiple
cell
types
within
tumors.
This
tumor
heterogeneity
at
least
partly
results
from
genomic
instability
leading
to
sub-clonal
cellular
differentiation.
The
differentiated
populations
originate
small
subset
cells
with
tumor-initiating
and
stem-like
properties.
These
cells,
termed
prostate
cancer
stem
(PCSCs),
play
crucial
roles
progression,
drug
resistance,
relapse.
review
discusses
origin,
hierarchy,
plasticity
PCSCs;
methods
for
isolation
enrichment
various
metabolic
signaling
pathways
involved
PCSC
induction
maintenance,
as
well
therapeutic
targeting.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 7, 2024
Large
cell
neuroendocrine
carcinoma
(LCNEC)
is
a
rare
subtype
of
prostate
cancer.
The
pathogenesis,
clinical
manifestation,
treatment
options,
and
prognosis
are
uncertain
underreported.
American Journal of Clinical and Experimental Urology,
Journal Year:
2024,
Volume and Issue:
12(4), P. 200 - 215
Published: Jan. 1, 2024
Histopathology,
which
is
the
gold-standard
for
prostate
cancer
diagnosis,
faces
significant
challenges.
With
ranking
among
most
common
cancers
in
United
States
and
worldwide,
pathologists
experience
an
increased
number
biopsies.
At
same
time,
precise
pathological
assessment
classification
are
necessary
risk
stratification
treatment
decisions
care,
adding
to
challenge
pathologists.
Recent
advancement
digital
pathology
makes
artificial
intelligence
learning
tools
adopted
histopathology
feasible.
In
this
review,
we
introduce
concept
of
AI
its
various
techniques
field
histopathology.
We
summarize
clinical
applications
cancer,
including
grading,
prognosis
evaluation,
options.
also
discuss
how
can
be
integrated
into
routine
workflow.
these
rapid
advancements,
it
evident
that
go
beyond
initial
goal
being
diagnosis
grading.
Instead,
provide
additional
information
improve
long-term
patient
outcomes
by
assessing
detailed
histopathologic
features
at
pixel
level
using
AI.
Our
review
not
only
provides
a
comprehensive
summary
existing
research
but
offers
insights
future
advancements.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(4), P. 692 - 692
Published: Feb. 9, 2021
Neuroendocrine
plasticity
and
treatment-induced
neuroendocrine
phenotypes
have
recently
been
proposed
as
important
resistance
mechanisms
underlying
prostate
cancer
progression.
Treatment-induced
(t-NEPC)
is
highly
aggressive
subtype
of
castration-resistant
which
develops
for
one
fifth
patients
under
prolonged
androgen
deprivation.
In
recent
years,
understanding
molecular
features
phenotypic
changes
in
has
grown.
However,
there
are
still
fundamental
questions
to
be
answered
this
emerging
research
field,
example,
why
how
do
the
treatment-resistant
cells
acquire
neuron-like
phenotype.
The
advantages
change
role
tumor
microenvironment
controlling
cellular
emergence
forms
mostly
unknown.
Here,
we
discuss
functional
links
between
neurodevelopmental
processes
progression
treatment
resistance.
We
provide
an
overview
neurite-like
whether
reported
t-NEPC
pathways
proteins
relate
like
neurogenesis
axonogenesis
during
development
also
novel
therapeutic
targets
modulating
plasticity.
