Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(24), P. 7830 - 7830
Published: Dec. 22, 2024
Background/Objectives:
Early
studies
have
suggested
that
the
SARS-CoV-2
virus
has
a
deleterious
effect
on
bone
mineral
density
and
may
increase
risk
of
pathological
fractures.
This
study
characterized
vertebral
compression
fractures
in
patients
with
without
prior
diagnosis
COVID-19.
Methods:
Using
nationwide
claims
database,
this
retrospective
used
ICD-10
billing
codes
to
identify
fracture
from
January
2020
April
2022.
Two
cohorts
were
created
based
whether
had
concurrent
Patient
demographics,
comorbidities,
outcome
measures
by
descriptive
analysis.
Results:
In
total,
413,425
met
inclusion
criteria.
Among
them,
total
23,148
(5.60%)
COVID-19
at
time
their
fracture.
patients,
incidences
0.42%
0.33%
2021,
comparison
historical
average
yearly
incidence
0.17%
across
all
patients.
The
higher
rate
vitamin
D
deficiency
(OR:
1.25)
lower
routine
healing
0.61).
more
likely
be
osteoporotic
0.88),
experience
additional
0.38),
kyphoplasty
or
vertebroplasty
0.73).
Conclusions:
Despite
rates
osteoporosis,
concomitant
exhibited
Although
research
is
needed,
these
results
support
increasing
health
surveillance
history
infection.
Current Osteoporosis Reports,
Journal Year:
2024,
Volume and Issue:
22(1), P. 115 - 121
Published: Jan. 16, 2024
Abstract
Purpose
of
Review
With
the
recent
explosion
in
use
artificial
intelligence
(AI)
and
specifically
ChatGPT,
we
sought
to
determine
whether
ChatGPT
could
be
used
assist
writing
credible,
peer-reviewed,
scientific
review
articles.
We
also
assess,
a
study,
advantages
limitations
using
for
this
purpose.
To
accomplish
this,
3
topics
importance
musculoskeletal
research
were
selected:
(1)
intersection
Alzheimer’s
disease
bone;
(2)
neural
regulation
fracture
healing;
(3)
COVID-19
health.
For
each
these
topics,
approaches
write
manuscript
drafts
undertaken:
human
only;
only
(AI-only);
combination
approach
#1
#2
(AI-assisted).
Articles
extensively
fact
checked
edited
ensure
quality,
resulting
final
manuscripts
that
significantly
different
from
original
drafts.
Numerous
parameters
measured
throughout
process
quantitate
disadvantages
approaches.
Recent
Findings
Overall,
AI
decreased
time
spent
article,
but
required
more
extensive
checking.
AI-only
approach,
up
70%
references
cited
found
inaccurate.
Interestingly,
AI-assisted
resulted
highest
similarity
indices
suggesting
higher
likelihood
plagiarism.
Finally,
although
technology
is
rapidly
changing,
at
4.0
had
cutoff
date
September
2021
rendering
identification
articles
impossible.
Therefore,
all
literature
published
past
was
manually
provided
#3
identical
contemporary
citations.
As
result,
health
topic,
abandoned
midstream
due
overlap
with
#3.
Summary
The
main
objective
study
see
scientifically
appropriate
manner
improve
process.
Indeed,
reduced
significant
inaccuracies.
latter
necessitates
cannot
currently
alone
careful
oversight
by
humans
Current Osteoporosis Reports,
Journal Year:
2024,
Volume and Issue:
22(1), P. 146 - 151
Published: Jan. 13, 2024
Abstract
Purpose
of
Review
There
were
two
primary
purposes
to
our
reviews.
First,
provide
an
update
the
scientific
community
about
impacts
COVID-19
on
musculoskeletal
health.
Second,
was
determine
value
using
a
large
language
model,
ChatGPT
4.0,
in
process
writing
review
article.
To
accomplish
these
objectives,
we
originally
set
out
write
three
articles
topic
different
methods
produce
initial
drafts
articles.
The
first
article
written
traditional
manner
by
humans,
second
be
exclusively
(AI-only
or
AIO),
and
third
approach
input
outline
references
selected
humans
from
1
into
ChatGPT,
AI
assist
completing
(AI-assisted
AIA).
All
extensively
fact-checked
edited
all
co-authors
leading
final
manuscripts,
which
significantly
drafts.
Recent
Findings
Unfortunately,
during
this
process,
it
became
clear
that
2
not
feasible
for
very
recent
like
as
at
time,
4.0
had
cutoff
date
September
2021
published
after
provided
making
approaches
3
virtually
identical.
Therefore,
only
(human
AI-assisted).
Here
found
human-only
took
less
time
complete
than
AI-assisted
approach.
This
largely
due
number
hours
required
fact-check
edit
manuscript.
Of
note,
resulted
inaccurate
attributions
(about
20%)
higher
similarity
index
suggesting
increased
risk
plagiarism.
Summary
main
aim
project
whether
use
could
improve
Based
experience,
with
current
state
technology,
would
advised
solely
article,
especially
topic.
Current Osteoporosis Reports,
Journal Year:
2024,
Volume and Issue:
22(1), P. 217 - 221
Published: Jan. 13, 2024
Three
review
articles
have
been
written
that
discuss
the
roles
of
central
and
peripheral
nervous
systems
in
fracture
healing.
While
content
among
is
overlapping,
there
a
key
difference
between
them:
use
artificial
intelligence
(AI).
In
one
paper,
first
draft
was
solely
by
humans.
second
AI
using
ChatGPT
4.0
(AI-only
or
AIO).
third
but
literature
references
were
supplied
from
human-written
paper
(AI-assisted
AIA).
This
project
done
to
evaluate
capacity
conduct
scientific
writing.
Importantly,
all
manuscripts
fact
checked
extensively
edited
co-authors
rendering
final
manuscript
drafts
significantly
different
drafts.
Current Osteoporosis Reports,
Journal Year:
2024,
Volume and Issue:
22(1), P. 177 - 181
Published: Jan. 16, 2024
Abstract
Purpose
of
Review
This
Comment
represents
three
review
articles
on
the
relationship
between
Alzheimer’s
disease,
osteoporosis,
and
fracture
in
an
exploration
benefits
that
AI
can
provide
scientific
writing.
The
first
drafts
were
written
(1)
entirely
by
humans;
(2)
ChatGPT
4.0
(AI-only
or
AIO);
(3)
humans
whereby
selected
literature
references,
but
completed
writing
(AI-assisted
AIA).
Importantly,
each
article
was
edited
carefully
checked
for
accuracy
all
co-authors
resulting
a
final
manuscript
which
significantly
different
from
original
draft.
Recent
Findings
human-written
took
most
time
start
to
finish,
AI-only
least
time,
AI-assisted
fell
two.
When
comparing
drafts,
had
higher
percentages
text
than
human
article.
paper
percentage
incorrect
references
draft
paper.
similarity
score
other
two
when
examined
plagiarism
identification
software.
Summary
experiment
used
tracking,
editing,
comparison
software
examine
risks
using
assist
It
showed
while
may
reduce
total
hallucinations
prevalent
issues
with
this
method
editing
still
necessary
ensure
accuracy.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 979 - 979
Published: Feb. 3, 2025
Background/Objectives:
The
COVID-19
pandemic
has
increased
interest
in
osteoimmunology
because
of
the
impact
SARS-CoV-2
on
both
immune
system
and
bone
microenvironment.
Soluble
CD14ST
could
influence
production
osteoimmunological
regulators
osteoclast
differentiation.
aim
this
study
is
to
evaluate
role
sCD14ST
COVID-19’s
effects
remodeling—evaluating,
particular,
correlation
with
new-generation
biomarkers—and
acquire
comprehensive
knowledge
disease
skeletal
system.
Methods:
serum
level
was
measured
COVID-19-positive
COVID-19-negative
patients
undergoing
orthopedic
surgery
correlated
inflammatory
biomarkers
RANKL/OPG,
FGF23,
IL-6,
C-reactive
protein
(CRP),
procalcitonin
(PCT),
sRAGE,
SuPAR.
Results:
In
our
patients,
showed
a
strong
increase
significant
decrease
tandem
infection
resolution,
confirming
its
diagnostic
prognostic
value.
more
clinically
relevant
than
two
canonically
makers
used
clinical
protocols,
CRP
PCT,
displayed
good
positive
SuPAR
negative
sRAGE.
Conclusions:
Monitoring
along
may
offer
valuable
insights
into
dysregulation
bone-related
complications
conditions
characterized
by
inflammation.
These
soluble
receptors
represent
important
links
between
activation
metabolism,
especially
context
diseases
like
COVID-19,
where
response
fragility.
Balneo and PRM Research Journal,
Journal Year:
2024,
Volume and Issue:
15(Vol.15, no. 2), P. 693 - 693
Published: June 21, 2024
Primary
osteoporosis,
a
geriatric
bone
metabolic
condition
affecting
both
the
mineral
density
and
microarchitecture,
comes
with
complex
burden.
Bone
turnover
markers
tidily
reflect
changes
of
skeleton
status
that
are
part
physiological
process
or
theyhighlight
abnormal
including
in
osteoporosis
addition
to
other
biomolecules
evaluation
such
as
hormones,
inflammatory
markers,
myokines
adipokines.
In
this
narrative
review,
we
aimed
highlight
several
aspects
regarding
osteoporosis-related
rehabilitation
amid
mitigating
role
physical
exercise
formation
booster.
assays,
by
capturing
essence
remodelling,
registered
great
progress
during
latest
years,
thus
show-ing
an
enhanced
index
applicability
daily
practice
(despite
being
known
studied
for
more
than
three
decades).
Irisin,
novel
player
muscle-bone-metabolism
cross-talk,
represents
muscle-derivate
hormone
is
expected
interplay
between
formation.
Other
concurrent
signal
transduction
pathways
include
recently
described
biomarkers
preptin
spectrum
associated
serotonin-LRP5-Wnt/beta
catenin
canonical
non-canonical
loops.
Current
pitfalls
topic
personalized
recommendation
activity
due
severe
co-morbidities,
lack
homogenous
studies
measure
intervention
consecutive
health
variations
using
different
centers.
To
conclude,
monitoring
protocol
osteoporotic
patients
under
specific
medication
against
bisphosphonates
drug
holiday,
assays
stands
practical
insight
every
day
practice.
The
contributing
boost
reflected
these
well
understood
across
multitude
pathways.
However,
current
gap
use
surveillance
prescription
activity,
mechanical
load
programs
confirmed
so
far.
Keywords:
bone,
fracture,
rehabilitation,
exercise,
osteocalcin.
Journal of Medical Virology,
Journal Year:
2024,
Volume and Issue:
96(4)
Published: April 1, 2024
Abstract
The
Coronavirus
Disease
2019
(COVID‐19)
pandemic
has
resulted
in
the
loss
of
millions
lives,
although
a
majority
those
infected
have
managed
to
survive.
Consequently,
set
outcomes,
identified
as
long
COVID,
is
now
emerging.
While
primary
target
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
system,
impact
COVID‐19
extends
various
body
parts,
including
bone.
This
study
aims
investigate
effects
SARS‐CoV‐2
infection
on
osteoclastogenesis,
utilizing
both
ancestral
and
Omicron
viral
strains.
Monocyte‐derived
macrophages,
which
serve
precursors
osteoclasts,
were
exposed
variants.
However,
proved
abortive,
even
though
ACE2
receptor
expression
increased
postinfection,
with
no
significant
cellular
viability
redox
balance.
Both
strains
heightened
osteoclast
formation
dose‐dependent
manner,
well
CD51/61
bone
resorptive
ability.
Notably,
induced
early
pro‐inflammatory
M1
macrophage
polarization,
shifting
toward
an
M2‐like
profile.
Osteoclastogenesis‐related
genes
(RANK,
NFATc1,
DC‐STAMP,
MMP9)
upregulated,
surprisingly,
variants
promoted
RANKL‐independent
formation.
thorough
investigation
illuminates
intricate
interplay
between
precursors,
suggesting
potential
implications
for
homeostasis
opening
new
avenues
therapeutic
exploration
COVID‐19.
Healthcare,
Journal Year:
2024,
Volume and Issue:
12(17), P. 1793 - 1793
Published: Sept. 8, 2024
Myasthenia
gravis
(MG)
patients
often
require
long-term
glucocorticoid
therapy,
which
may
affect
bone
health.
This
study
aimed
to
assess
changes
in
mineral
density
(BMD),
evaluate
osteoporotic
fracture
incidence,
and
examine
the
relationship
between
MG-specific
factors
health
outcomes
over
a
10-year
period.
single-center,
prospective
cohort
included
28
MG
patients.
BMD,
T-scores,
Z-scores,
turnover
markers
were
measured
at
baseline.
FRAX®
scores
calculated
adjusted
for
dose.
Fracture
occurrence
was
monitored
10
years.
Five
(17.9%)
experienced
major
fractures
during
follow-up.
The
group
had
significantly
lower
baseline
BMD
T-scores
than
no-fracture
group.
Baseline
risk
higher
(median
19.0%
vs.
5.7%,
p
=
0.001).
progressed
from
osteopenia
osteoporosis
by
end
of
this
study.
highlights
importance
early
regular
assessments
patients,
particularly
those
receiving
therapy.
tool
be
valuable
stratification
population.
These
findings
can
inform
clinical
practice
improve
management
strategies
who
are
fractures.