Incidence and Outcomes of Vertebral Compression Fracture Among Patients Infected with COVID-19 DOI Open Access
Helen Zhang, Mariah Balmaceno-Criss, Abigail M. Fruge

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7830 - 7830

Published: Dec. 22, 2024

Background/Objectives: Early studies have suggested that the SARS-CoV-2 virus has a deleterious effect on bone mineral density and may increase risk of pathological fractures. This study characterized vertebral compression fractures in patients with without prior diagnosis COVID-19. Methods: Using nationwide claims database, this retrospective used ICD-10 billing codes to identify fracture from January 2020 April 2022. Two cohorts were created based whether had concurrent Patient demographics, comorbidities, outcome measures by descriptive analysis. Results: In total, 413,425 met inclusion criteria. Among them, total 23,148 (5.60%) COVID-19 at time their fracture. patients, incidences 0.42% 0.33% 2021, comparison historical average yearly incidence 0.17% across all patients. The higher rate vitamin D deficiency (OR: 1.25) lower routine healing 0.61). more likely be osteoporotic 0.88), experience additional 0.38), kyphoplasty or vertebroplasty 0.73). Conclusions: Despite rates osteoporosis, concomitant exhibited Although research is needed, these results support increasing health surveillance history infection.

Language: Английский

The Use of Artificial Intelligence in Writing Scientific Review Articles DOI Creative Commons
Melissa A. Kacena, Lilian I. Plotkin, Jill C. Fehrenbacher

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 115 - 121

Published: Jan. 16, 2024

Abstract Purpose of Review With the recent explosion in use artificial intelligence (AI) and specifically ChatGPT, we sought to determine whether ChatGPT could be used assist writing credible, peer-reviewed, scientific review articles. We also assess, a study, advantages limitations using for this purpose. To accomplish this, 3 topics importance musculoskeletal research were selected: (1) intersection Alzheimer’s disease bone; (2) neural regulation fracture healing; (3) COVID-19 health. For each these topics, approaches write manuscript drafts undertaken: human only; only (AI-only); combination approach #1 #2 (AI-assisted). Articles extensively fact checked edited ensure quality, resulting final manuscripts that significantly different from original drafts. Numerous parameters measured throughout process quantitate disadvantages approaches. Recent Findings Overall, AI decreased time spent article, but required more extensive checking. AI-only approach, up 70% references cited found inaccurate. Interestingly, AI-assisted resulted highest similarity indices suggesting higher likelihood plagiarism. Finally, although technology is rapidly changing, at 4.0 had cutoff date September 2021 rendering identification articles impossible. Therefore, all literature published past was manually provided #3 identical contemporary citations. As result, health topic, abandoned midstream due overlap with #3. Summary The main objective study see scientifically appropriate manner improve process. Indeed, reduced significant inaccuracies. latter necessitates cannot currently alone careful oversight by humans

Language: Английский

Citations

76

The Utility of AI in Writing a Scientific Review Article on the Impacts of COVID-19 on Musculoskeletal Health DOI Creative Commons

Olatundun D. Awosanya,

Alexander Harris,

Amy Creecy

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 146 - 151

Published: Jan. 13, 2024

Abstract Purpose of Review There were two primary purposes to our reviews. First, provide an update the scientific community about impacts COVID-19 on musculoskeletal health. Second, was determine value using a large language model, ChatGPT 4.0, in process writing review article. To accomplish these objectives, we originally set out write three articles topic different methods produce initial drafts articles. The first article written traditional manner by humans, second be exclusively (AI-only or AIO), and third approach input outline references selected humans from 1 into ChatGPT, AI assist completing (AI-assisted AIA). All extensively fact-checked edited all co-authors leading final manuscripts, which significantly drafts. Recent Findings Unfortunately, during this process, it became clear that 2 not feasible for very recent like as at time, 4.0 had cutoff date September 2021 published after provided making approaches 3 virtually identical. Therefore, only (human AI-assisted). Here found human-only took less time complete than AI-assisted approach. This largely due number hours required fact-check edit manuscript. Of note, resulted inaccurate attributions (about 20%) higher similarity index suggesting increased risk plagiarism. Summary main aim project whether use could improve Based experience, with current state technology, would advised solely article, especially topic.

Language: Английский

Citations

16

Using AI to Write a Review Article Examining the Role of the Nervous System on Skeletal Homeostasis and Fracture Healing DOI Creative Commons
Murad K. Nazzal, Ashlyn J. Morris,

Reginald S. Parker

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 217 - 221

Published: Jan. 13, 2024

Three review articles have been written that discuss the roles of central and peripheral nervous systems in fracture healing. While content among is overlapping, there a key difference between them: use artificial intelligence (AI). In one paper, first draft was solely by humans. second AI using ChatGPT 4.0 (AI-only or AIO). third but literature references were supplied from human-written paper (AI-assisted AIA). This project done to evaluate capacity conduct scientific writing. Importantly, all manuscripts fact checked extensively edited co-authors rendering final manuscript drafts significantly different drafts.

Language: Английский

Citations

15

Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer’s Disease and Bone DOI Creative Commons
Tyler J. Margetts, Sonali Karnik,

Hannah S. Wang

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 177 - 181

Published: Jan. 16, 2024

Abstract Purpose of Review This Comment represents three review articles on the relationship between Alzheimer’s disease, osteoporosis, and fracture in an exploration benefits that AI can provide scientific writing. The first drafts were written (1) entirely by humans; (2) ChatGPT 4.0 (AI-only or AIO); (3) humans whereby selected literature references, but completed writing (AI-assisted AIA). Importantly, each article was edited carefully checked for accuracy all co-authors resulting a final manuscript which significantly different from original draft. Recent Findings human-written took most time start to finish, AI-only least time, AI-assisted fell two. When comparing drafts, had higher percentages text than human article. paper percentage incorrect references draft paper. similarity score other two when examined plagiarism identification software. Summary experiment used tracking, editing, comparison software examine risks using assist It showed while may reduce total hallucinations prevalent issues with this method editing still necessary ensure accuracy.

Language: Английский

Citations

12

The Evaluation of New-Generation Biomarker sCD14ST Provides New Insight into COVID-19’s Effect on Bone Remodeling DOI Open Access
Emanuela Galliera, Luca Massaccesi, Laura Mangiavini

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 979 - 979

Published: Feb. 3, 2025

Background/Objectives: The COVID-19 pandemic has increased interest in osteoimmunology because of the impact SARS-CoV-2 on both immune system and bone microenvironment. Soluble CD14ST could influence production osteoimmunological regulators osteoclast differentiation. aim this study is to evaluate role sCD14ST COVID-19’s effects remodeling—evaluating, particular, correlation with new-generation biomarkers—and acquire comprehensive knowledge disease skeletal system. Methods: serum level was measured COVID-19-positive COVID-19-negative patients undergoing orthopedic surgery correlated inflammatory biomarkers RANKL/OPG, FGF23, IL-6, C-reactive protein (CRP), procalcitonin (PCT), sRAGE, SuPAR. Results: In our patients, showed a strong increase significant decrease tandem infection resolution, confirming its diagnostic prognostic value. more clinically relevant than two canonically makers used clinical protocols, CRP PCT, displayed good positive SuPAR negative sRAGE. Conclusions: Monitoring along may offer valuable insights into dysregulation bone-related complications conditions characterized by inflammation. These soluble receptors represent important links between activation metabolism, especially context diseases like COVID-19, where response fragility.

Language: Английский

Citations

0

Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence DOI
Luigi di Filippo,

Mauro Doga,

Francesca Mangini

et al.

Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0

Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures DOI Creative Commons

Keli Ou,

Jiarui Chen, Jichong Zhu

et al.

Clinics in Orthopedic Surgery, Journal Year: 2025, Volume and Issue: 17

Published: Jan. 1, 2025

Language: Английский

Citations

0

Physical exercise as part of the rehabilitation in primary osteoporosis: insights into the signal transduction bone formation pathways DOI Creative Commons
Mihaela Stanciu, Claudiu Nistor, Mădălina Gabriela Iliescu

et al.

Balneo and PRM Research Journal, Journal Year: 2024, Volume and Issue: 15(Vol.15, no. 2), P. 693 - 693

Published: June 21, 2024

Primary osteoporosis, a geriatric bone metabolic condition affecting both the mineral density and microarchitecture, comes with complex burden. Bone turnover markers tidily reflect changes of skeleton status that are part physiological process or theyhighlight abnormal including in osteoporosis addition to other biomolecules evaluation such as hormones, inflammatory markers, myokines adipokines. In this narrative review, we aimed highlight several aspects regarding osteoporosis-related rehabilitation amid mitigating role physical exercise formation booster. assays, by capturing essence remodelling, registered great progress during latest years, thus show-ing an enhanced index applicability daily practice (despite being known studied for more than three decades). Irisin, novel player muscle-bone-metabolism cross-talk, represents muscle-derivate hormone is expected interplay between formation. Other concurrent signal transduction pathways include recently described biomarkers preptin spectrum associated serotonin-LRP5-Wnt/beta catenin canonical non-canonical loops. Current pitfalls topic personalized recommendation activity due severe co-morbidities, lack homogenous studies measure intervention consecutive health variations using different centers. To conclude, monitoring protocol osteoporotic patients under specific medication against bisphosphonates drug holiday, assays stands practical insight every day practice. The contributing boost reflected these well understood across multitude pathways. However, current gap use surveillance prescription activity, mechanical load programs confirmed so far. Keywords: bone, fracture, rehabilitation, exercise, osteocalcin.

Language: Английский

Citations

3

The abortive SARS‐CoV‐2 infection of osteoclast precursors promotes their differentiation into osteoclasts DOI

Franco Agustín Sviercz,

Patricio Jarmoluk,

Joshua Godoy Coto

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(4)

Published: April 1, 2024

Abstract The Coronavirus Disease 2019 (COVID‐19) pandemic has resulted in the loss of millions lives, although a majority those infected have managed to survive. Consequently, set outcomes, identified as long COVID, is now emerging. While primary target severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) system, impact COVID‐19 extends various body parts, including bone. This study aims investigate effects SARS‐CoV‐2 infection on osteoclastogenesis, utilizing both ancestral and Omicron viral strains. Monocyte‐derived macrophages, which serve precursors osteoclasts, were exposed variants. However, proved abortive, even though ACE2 receptor expression increased postinfection, with no significant cellular viability redox balance. Both strains heightened osteoclast formation dose‐dependent manner, well CD51/61 bone resorptive ability. Notably, induced early pro‐inflammatory M1 macrophage polarization, shifting toward an M2‐like profile. Osteoclastogenesis‐related genes (RANK, NFATc1, DC‐STAMP, MMP9) upregulated, surprisingly, variants promoted RANKL‐independent formation. thorough investigation illuminates intricate interplay between precursors, suggesting potential implications for homeostasis opening new avenues therapeutic exploration COVID‐19.

Language: Английский

Citations

2

Long-Term Bone Density Changes and Fracture Risk in Myasthenia Gravis: Implications for FRAX® Tool Application DOI Open Access
Shingo Konno,

Takafumi Uchi,

Hideo Kihara

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(17), P. 1793 - 1793

Published: Sept. 8, 2024

Myasthenia gravis (MG) patients often require long-term glucocorticoid therapy, which may affect bone health. This study aimed to assess changes in mineral density (BMD), evaluate osteoporotic fracture incidence, and examine the relationship between MG-specific factors health outcomes over a 10-year period. single-center, prospective cohort included 28 MG patients. BMD, T-scores, Z-scores, turnover markers were measured at baseline. FRAX® scores calculated adjusted for dose. Fracture occurrence was monitored 10 years. Five (17.9%) experienced major fractures during follow-up. The group had significantly lower baseline BMD T-scores than no-fracture group. Baseline risk higher (median 19.0% vs. 5.7%, p = 0.001). progressed from osteopenia osteoporosis by end of this study. highlights importance early regular assessments patients, particularly those receiving therapy. tool be valuable stratification population. These findings can inform clinical practice improve management strategies who are fractures.

Language: Английский

Citations

1