Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 13, 2024
Observational studies have found associations between reproductive factors and bone density in women. However, the causal relationships are not well understood. This study aims to investigate whether various causally related at different skeletal sites using both univariable multivariable Mendelian randomization (MR) methods.
Language: Английский
Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 115 - 121
Published: Jan. 16, 2024
Abstract Purpose of Review With the recent explosion in use artificial intelligence (AI) and specifically ChatGPT, we sought to determine whether ChatGPT could be used assist writing credible, peer-reviewed, scientific review articles. We also assess, a study, advantages limitations using for this purpose. To accomplish this, 3 topics importance musculoskeletal research were selected: (1) intersection Alzheimer’s disease bone; (2) neural regulation fracture healing; (3) COVID-19 health. For each these topics, approaches write manuscript drafts undertaken: human only; only (AI-only); combination approach #1 #2 (AI-assisted). Articles extensively fact checked edited ensure quality, resulting final manuscripts that significantly different from original drafts. Numerous parameters measured throughout process quantitate disadvantages approaches. Recent Findings Overall, AI decreased time spent article, but required more extensive checking. AI-only approach, up 70% references cited found inaccurate. Interestingly, AI-assisted resulted highest similarity indices suggesting higher likelihood plagiarism. Finally, although technology is rapidly changing, at 4.0 had cutoff date September 2021 rendering identification articles impossible. Therefore, all literature published past was manually provided #3 identical contemporary citations. As result, health topic, abandoned midstream due overlap with #3. Summary The main objective study see scientifically appropriate manner improve process. Indeed, reduced significant inaccuracies. latter necessitates cannot currently alone careful oversight by humans
Language: Английский
Citations
75
Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 146 - 151
Published: Jan. 13, 2024
Abstract Purpose of Review There were two primary purposes to our reviews. First, provide an update the scientific community about impacts COVID-19 on musculoskeletal health. Second, was determine value using a large language model, ChatGPT 4.0, in process writing review article. To accomplish these objectives, we originally set out write three articles topic different methods produce initial drafts articles. The first article written traditional manner by humans, second be exclusively (AI-only or AIO), and third approach input outline references selected humans from 1 into ChatGPT, AI assist completing (AI-assisted AIA). All extensively fact-checked edited all co-authors leading final manuscripts, which significantly drafts. Recent Findings Unfortunately, during this process, it became clear that 2 not feasible for very recent like as at time, 4.0 had cutoff date September 2021 published after provided making approaches 3 virtually identical. Therefore, only (human AI-assisted). Here found human-only took less time complete than AI-assisted approach. This largely due number hours required fact-check edit manuscript. Of note, resulted inaccurate attributions (about 20%) higher similarity index suggesting increased risk plagiarism. Summary main aim project whether use could improve Based experience, with current state technology, would advised solely article, especially topic.
Language: Английский
Citations
16
Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 217 - 221
Published: Jan. 13, 2024
Three review articles have been written that discuss the roles of central and peripheral nervous systems in fracture healing. While content among is overlapping, there a key difference between them: use artificial intelligence (AI). In one paper, first draft was solely by humans. second AI using ChatGPT 4.0 (AI-only or AIO). third but literature references were supplied from human-written paper (AI-assisted AIA). This project done to evaluate capacity conduct scientific writing. Importantly, all manuscripts fact checked extensively edited co-authors rendering final manuscript drafts significantly different drafts.
Language: Английский
Citations
15
Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 177 - 181
Published: Jan. 16, 2024
Abstract Purpose of Review This Comment represents three review articles on the relationship between Alzheimer’s disease, osteoporosis, and fracture in an exploration benefits that AI can provide scientific writing. The first drafts were written (1) entirely by humans; (2) ChatGPT 4.0 (AI-only or AIO); (3) humans whereby selected literature references, but completed writing (AI-assisted AIA). Importantly, each article was edited carefully checked for accuracy all co-authors resulting a final manuscript which significantly different from original draft. Recent Findings human-written took most time start to finish, AI-only least time, AI-assisted fell two. When comparing drafts, had higher percentages text than human article. paper percentage incorrect references draft paper. similarity score other two when examined plagiarism identification software. Summary experiment used tracking, editing, comparison software examine risks using assist It showed while may reduce total hallucinations prevalent issues with this method editing still necessary ensure accuracy.
Language: Английский
Citations
12
European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(1), P. 3466 - 3490
Published: May 10, 2024
Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed
Language: Английский
Citations
6
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0304410 - e0304410
Published: May 29, 2024
The association between Alzheimer’s disease and metabolic disorders as significant risk factors is widely acknowledged. However, the intricate molecular mechanism intertwining these conditions remains elusive. To address this knowledge gap, we conducted a thorough investigation using bioinformatics method to illuminate connections pathways that provide novel perspectives on disorders’ pathological clinical features. Microarray datasets (GSE5281, GSE122063) from Gene Expression Omnibus (GEO) database facilitated way identify genes with differential expression in (141 genes). Leveraging CoreMine, CTD, Card databases, extracted associated conditions, including hypertension, non-alcoholic fatty liver disease, diabetes. Subsequent analysis uncovered overlapping implicated revealing shared links. We utilized String HIPPIE databases visualize genes’ protein-protein interactions (PPI) constructed PPI network Cytoscape MCODE plugin. SPP1, CD44, IGF1, FLT1 were identified crucial molecules main cluster of syndrome. Enrichment by DAVID dataset was employed highlighted SPP1 target, its receptor CD44 playing role inflammatory cascade disruption insulin signaling, contributing neurodegenerative aspects disease. ECM-receptor interactions, focal adhesion, PI3K/Akt may all mediate effects. Additionally, investigated potential medications repurposing links DGIdb database, Tacrolimus Calcitonin promising candidates, particularly since they possess binding sites molecule. In conclusion, our study unveils bridges syndrome AD, providing insights into their pathophysiology for therapeutic interventions.
Language: Английский
Citations
5
World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)
Published: Jan. 14, 2025
BACKGROUND Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential providing nutritional guidance for patients with Alzheimer’s disease (AD) remains relatively unexplored. AIM To explore clinical efficacy BCA-based dietary nutrition scheme on bone metabolism AD patients. METHODS This retrospective study included 96 complicated by osteoporosis who were admitted to The Third Hospital Quzhou between January 2023 December 2024. Based data from previous similar studies, randomly assigned either a routine diet (RD) group (n = 48) or personalized (PN) 48). RD received conventional guidance, while PN individualized intervention measures based human BCA. period lasted 12 weeks. Bone mineral density (BMD), body mass index (BMI), muscle mass, content, osteocalcin, 25-hydroxyvitamin D, procollagen type I N-terminal propeptide (PINP), beta C-terminal telopeptide collagen (β-CTX), serum calcium measured compared two groups before weeks after intervention. RESULTS No significant differences observed terms age, sex, height, BMI, other baseline (P > 0.05). In both groups, BMI did not show changes 0.05), whereas content significantly increased < After intervention, differ that group, but higher proportion had T score -1 mini-mental state examination (MMSE) was MMSE than post-intervention pre-intervention levels Before calcium, PINP, β-CTX, D different exhibited well lower PINP higher, β-CTX CONCLUSION regimen plays crucial role improving BMD metabolism, effects surpass those strategies. findings this provide strong evidence
Language: Английский
Citations
0
Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 20, 2025
Language: Английский
Citations
0
Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 37(1)
Published: Dec. 27, 2024
Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly global population, increasing in prevalence. These conditions closely associated, shared risk factors, underlying biological mechanisms potential direct causal pathways. In this review, epidemiological mechanistic links between mild skeletal health explored. Discussion will focus on how changes brain bone signalling can underly associations these conditions, consider molecular cellular drivers context inflammation gut microbiome. There is a complex interplay nutritional changes, which may precede or follow onset impairment (MCI) dementia, health. Polypharmacy patients MCI there difficult prescribing decisions to be made due elevated falls associated many drugs used for problems, consequently increase fracture risk. Some medications prescribed directly impact addition, have difficulty remembering medication without assistance, meaning that but not taken. Cognitive improved delayed by physical activity exercise, evidence additional benefits fractures. Research gaps priorities aim reducing burden fractures people also discussed.
Language: Английский
Citations
1
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 13, 2024
Observational studies have found associations between reproductive factors and bone density in women. However, the causal relationships are not well understood. This study aims to investigate whether various causally related at different skeletal sites using both univariable multivariable Mendelian randomization (MR) methods.
Language: Английский
Citations
0